Abnormal interhemispheric resting state functional connectivity in Parkinson’s disease patients with impulse control disorders

Abstract Impulse control disorders (ICD) in Parkinson’s disease (PD) might be attributed to misestimate of rewards or the failure to curb inappropriate choices. The mechanisms underlying ICD were reported to involve the lateralization of monoamine network. Our objective was to probe the significant...

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Autores principales:	Caiting Gan, Lina Wang, Min Ji, Kewei Ma, Huimin Sun, Kezhong Zhang, Yongsheng Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f543fede9cf84311ab2dbc06d1103e78
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spelling	oai:doaj.org-article:f543fede9cf84311ab2dbc06d1103e782021-12-02T16:14:04ZAbnormal interhemispheric resting state functional connectivity in Parkinson’s disease patients with impulse control disorders10.1038/s41531-021-00205-72373-8057https://doaj.org/article/f543fede9cf84311ab2dbc06d1103e782021-07-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00205-7https://doaj.org/toc/2373-8057Abstract Impulse control disorders (ICD) in Parkinson’s disease (PD) might be attributed to misestimate of rewards or the failure to curb inappropriate choices. The mechanisms underlying ICD were reported to involve the lateralization of monoamine network. Our objective was to probe the significant role of lateralization in the pathogenesis of ICD. Twenty-one PD patients with ICD (PD-ICD), thirty-three without ICD (PD-no ICD), and thirty-seven healthy controls (HCs) were recruited and performed T1-weighted, diffusion tensor imaging (DTI) scans and resting state functional magnetic resonance imaging (rs-fMRI). By applying the Voxel-mirrored Homotopic Connectivity (VMHC) and Freesurfer, we evaluated participants’ synchronicity of functional connectivity and structural changes between hemispheres. Also, tract-based spatial statistics (TBSS) was applied to compare fiber tracts differences. Relative to PD-no ICD group, PD-ICD group demonstrated reduced VMHC values in middle frontal gyrus (MFG). Compared to HCs, PD-ICD group mainly showed decreased VMHC values in MFG, middle and superior orbital frontal gyrus (OFG), inferior frontal gyrus (IFG) and caudate, which were related to reward processing and inhibitory control. The severity of impulsivity was negatively correlated with the mean VMHC values of MFG in PD-ICD group. Receiver operating characteristic (ROC) curves analyses uncovered that the mean VMHC values of MFG might be a potential marker identifying PD-ICD patients. However, we found no corresponding asymmetrical alteration in cortical thickness and no significant differences in fractional anisotropy (FA) and mean diffusivity (MD). Our results provided further evidence for asymmetry of functional connectivity in mesolimbic reward and response inhibition network in ICD.Caiting GanLina WangMin JiKewei MaHuimin SunKezhong ZhangYongsheng YuanNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Caiting Gan Lina Wang Min Ji Kewei Ma Huimin Sun Kezhong Zhang Yongsheng Yuan Abnormal interhemispheric resting state functional connectivity in Parkinson’s disease patients with impulse control disorders
description	Abstract Impulse control disorders (ICD) in Parkinson’s disease (PD) might be attributed to misestimate of rewards or the failure to curb inappropriate choices. The mechanisms underlying ICD were reported to involve the lateralization of monoamine network. Our objective was to probe the significant role of lateralization in the pathogenesis of ICD. Twenty-one PD patients with ICD (PD-ICD), thirty-three without ICD (PD-no ICD), and thirty-seven healthy controls (HCs) were recruited and performed T1-weighted, diffusion tensor imaging (DTI) scans and resting state functional magnetic resonance imaging (rs-fMRI). By applying the Voxel-mirrored Homotopic Connectivity (VMHC) and Freesurfer, we evaluated participants’ synchronicity of functional connectivity and structural changes between hemispheres. Also, tract-based spatial statistics (TBSS) was applied to compare fiber tracts differences. Relative to PD-no ICD group, PD-ICD group demonstrated reduced VMHC values in middle frontal gyrus (MFG). Compared to HCs, PD-ICD group mainly showed decreased VMHC values in MFG, middle and superior orbital frontal gyrus (OFG), inferior frontal gyrus (IFG) and caudate, which were related to reward processing and inhibitory control. The severity of impulsivity was negatively correlated with the mean VMHC values of MFG in PD-ICD group. Receiver operating characteristic (ROC) curves analyses uncovered that the mean VMHC values of MFG might be a potential marker identifying PD-ICD patients. However, we found no corresponding asymmetrical alteration in cortical thickness and no significant differences in fractional anisotropy (FA) and mean diffusivity (MD). Our results provided further evidence for asymmetry of functional connectivity in mesolimbic reward and response inhibition network in ICD.
format	article
author	Caiting Gan Lina Wang Min Ji Kewei Ma Huimin Sun Kezhong Zhang Yongsheng Yuan
author_facet	Caiting Gan Lina Wang Min Ji Kewei Ma Huimin Sun Kezhong Zhang Yongsheng Yuan
author_sort	Caiting Gan
title	Abnormal interhemispheric resting state functional connectivity in Parkinson’s disease patients with impulse control disorders
title_short	Abnormal interhemispheric resting state functional connectivity in Parkinson’s disease patients with impulse control disorders
title_full	Abnormal interhemispheric resting state functional connectivity in Parkinson’s disease patients with impulse control disorders
title_fullStr	Abnormal interhemispheric resting state functional connectivity in Parkinson’s disease patients with impulse control disorders
title_full_unstemmed	Abnormal interhemispheric resting state functional connectivity in Parkinson’s disease patients with impulse control disorders
title_sort	abnormal interhemispheric resting state functional connectivity in parkinson’s disease patients with impulse control disorders
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f543fede9cf84311ab2dbc06d1103e78
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Abnormal interhemispheric resting state functional connectivity in Parkinson’s disease patients with impulse control disorders

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