IMMUNOHISTOCHEMICAL EXPRESSION OF P53 IN INVASIVE DUCTAL CARCINOMA OF BREAST IN PAKISTANI WOMEN

Objective: To determine the frequency of immunohistochemical expression of p53 in invasive ductal carcinoma of breast in Pakistani women. Study Design: Descriptive, cross-sectional study. Place and Duration of Study: Department of Histopathology, Combined Military Hospital, Lahore, from Jul 2015 to...

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Autores principales:	Umair Aslam Shahzad khan, Muhammad Tahir Khadim, Syed Salman Ali, Muhammad Imran Khan Wajid, Akhter Ali Bajwa, Saba Anjum
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	immunohistochemical expression invasive ductal carcinoma p53 Medicine R Medicine (General) R5-920
Acceso en línea:	https://doi.org/10.51253/pafmj.v71iSuppl-1.3073 https://doaj.org/article/f544f452dce54241bae5c32260f7341c
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spelling	oai:doaj.org-article:f544f452dce54241bae5c32260f7341c2021-12-02T15:02:09ZIMMUNOHISTOCHEMICAL EXPRESSION OF P53 IN INVASIVE DUCTAL CARCINOMA OF BREAST IN PAKISTANI WOMENhttps://doi.org/10.51253/pafmj.v71iSuppl-1.30730030-96482411-8842https://doaj.org/article/f544f452dce54241bae5c32260f7341c2021-01-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/3073https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the frequency of immunohistochemical expression of p53 in invasive ductal carcinoma of breast in Pakistani women. Study Design: Descriptive, cross-sectional study. Place and Duration of Study: Department of Histopathology, Combined Military Hospital, Lahore, from Jul 2015 to Jan 2016. Methodology: This study involved 80 histopathological samples of invasive ductal carcinoma breast which were tested for p53 expression. Sample size with 80 cases was calculated using 95% confidence level and 10% margin of error while expected percentage of p53 expression will be 71.67%. Specimens were selected by non-probability, consecutive sampling. All specimens of newly diagnosed cases of invasive ducal carcinoma at CMH Lahore on histopathological examination of female patients aged between 15-80 years. IHC application of p53 was done as per technique mentioned in the manual given by the DAKO. Results: Patient age was calculated which was between 25 years and 80 years while mean age was 50.76 ± 11.80 years. Majority of the patients were aged between 25-50 years (n=44, 55.0%). In 54 (67.5%) patients lymph nodes were positive for tumor metastasis. Majority 64 (80%) of the tumors were Grade-II followed by Grade-III in 15 (18.7%) patients. The size of the tumor ranged from 0.2 cm to 14 cm with a mean of 4.16 ± 2.59 cm. p53 expression was positive in 38 (47.5%) patients. The expression of p53 was higher in patients who have positive lymph nodes (59.3% vs. 23.1%; p=0.002). However, expression of p53 was not so significant for age (p=0.079), tumor size (p=0.414) and tumor grade (p=0.176) groups. Conclusion: The frequency of p53 expression was found to be 47.5% in invasive mammary cancer in Pakistani population. The expression of p53 was higher in patients who have positive lymph nodes (59.3% vs. 23.1%; p=0.002). However, expression of p53 was not so significant for age (p=0.079), tumor size (p=0.414) and tumor grade (p=0.176) groups.Umair Aslam Shahzad khanMuhammad Tahir KhadimSyed Salman AliMuhammad Imran Khan WajidAkhter Ali BajwaSaba AnjumArmy Medical College Rawalpindiarticleimmunohistochemical expressioninvasive ductal carcinomap53MedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss SUPPL-1, Pp 142-146 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	immunohistochemical expression invasive ductal carcinoma p53 Medicine R Medicine (General) R5-920
spellingShingle	immunohistochemical expression invasive ductal carcinoma p53 Medicine R Medicine (General) R5-920 Umair Aslam Shahzad khan Muhammad Tahir Khadim Syed Salman Ali Muhammad Imran Khan Wajid Akhter Ali Bajwa Saba Anjum IMMUNOHISTOCHEMICAL EXPRESSION OF P53 IN INVASIVE DUCTAL CARCINOMA OF BREAST IN PAKISTANI WOMEN
description	Objective: To determine the frequency of immunohistochemical expression of p53 in invasive ductal carcinoma of breast in Pakistani women. Study Design: Descriptive, cross-sectional study. Place and Duration of Study: Department of Histopathology, Combined Military Hospital, Lahore, from Jul 2015 to Jan 2016. Methodology: This study involved 80 histopathological samples of invasive ductal carcinoma breast which were tested for p53 expression. Sample size with 80 cases was calculated using 95% confidence level and 10% margin of error while expected percentage of p53 expression will be 71.67%. Specimens were selected by non-probability, consecutive sampling. All specimens of newly diagnosed cases of invasive ducal carcinoma at CMH Lahore on histopathological examination of female patients aged between 15-80 years. IHC application of p53 was done as per technique mentioned in the manual given by the DAKO. Results: Patient age was calculated which was between 25 years and 80 years while mean age was 50.76 ± 11.80 years. Majority of the patients were aged between 25-50 years (n=44, 55.0%). In 54 (67.5%) patients lymph nodes were positive for tumor metastasis. Majority 64 (80%) of the tumors were Grade-II followed by Grade-III in 15 (18.7%) patients. The size of the tumor ranged from 0.2 cm to 14 cm with a mean of 4.16 ± 2.59 cm. p53 expression was positive in 38 (47.5%) patients. The expression of p53 was higher in patients who have positive lymph nodes (59.3% vs. 23.1%; p=0.002). However, expression of p53 was not so significant for age (p=0.079), tumor size (p=0.414) and tumor grade (p=0.176) groups. Conclusion: The frequency of p53 expression was found to be 47.5% in invasive mammary cancer in Pakistani population. The expression of p53 was higher in patients who have positive lymph nodes (59.3% vs. 23.1%; p=0.002). However, expression of p53 was not so significant for age (p=0.079), tumor size (p=0.414) and tumor grade (p=0.176) groups.
format	article
author	Umair Aslam Shahzad khan Muhammad Tahir Khadim Syed Salman Ali Muhammad Imran Khan Wajid Akhter Ali Bajwa Saba Anjum
author_facet	Umair Aslam Shahzad khan Muhammad Tahir Khadim Syed Salman Ali Muhammad Imran Khan Wajid Akhter Ali Bajwa Saba Anjum
author_sort	Umair Aslam Shahzad khan
title	IMMUNOHISTOCHEMICAL EXPRESSION OF P53 IN INVASIVE DUCTAL CARCINOMA OF BREAST IN PAKISTANI WOMEN
title_short	IMMUNOHISTOCHEMICAL EXPRESSION OF P53 IN INVASIVE DUCTAL CARCINOMA OF BREAST IN PAKISTANI WOMEN
title_full	IMMUNOHISTOCHEMICAL EXPRESSION OF P53 IN INVASIVE DUCTAL CARCINOMA OF BREAST IN PAKISTANI WOMEN
title_fullStr	IMMUNOHISTOCHEMICAL EXPRESSION OF P53 IN INVASIVE DUCTAL CARCINOMA OF BREAST IN PAKISTANI WOMEN
title_full_unstemmed	IMMUNOHISTOCHEMICAL EXPRESSION OF P53 IN INVASIVE DUCTAL CARCINOMA OF BREAST IN PAKISTANI WOMEN
title_sort	immunohistochemical expression of p53 in invasive ductal carcinoma of breast in pakistani women
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doi.org/10.51253/pafmj.v71iSuppl-1.3073 https://doaj.org/article/f544f452dce54241bae5c32260f7341c
work_keys_str_mv	AT umairaslamshahzadkhan immunohistochemicalexpressionofp53ininvasiveductalcarcinomaofbreastinpakistaniwomen AT muhammadtahirkhadim immunohistochemicalexpressionofp53ininvasiveductalcarcinomaofbreastinpakistaniwomen AT syedsalmanali immunohistochemicalexpressionofp53ininvasiveductalcarcinomaofbreastinpakistaniwomen AT muhammadimrankhanwajid immunohistochemicalexpressionofp53ininvasiveductalcarcinomaofbreastinpakistaniwomen AT akhteralibajwa immunohistochemicalexpressionofp53ininvasiveductalcarcinomaofbreastinpakistaniwomen AT sabaanjum immunohistochemicalexpressionofp53ininvasiveductalcarcinomaofbreastinpakistaniwomen
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IMMUNOHISTOCHEMICAL EXPRESSION OF P53 IN INVASIVE DUCTAL CARCINOMA OF BREAST IN PAKISTANI WOMEN

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