3D numerical simulation of acoustophoretic motion induced by boundary-driven acoustic streaming in standing surface acoustic wave microfluidics

Abstract Standing surface acoustic waves (SSAWs) have been widely utilized in microfluidic devices to manipulate various cells and micro/nano-objects. Despite widespread application, a time-/cost-efficient versatile 3D model that predicts particle behavior in such platforms is still lacking. Herein,...

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Autores principales:	Mohammad Sadegh Namnabat, Mahdi Moghimi Zand, Ehsan Houshfar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f5459b37d4e643589bd0abebc63a2287
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spelling	oai:doaj.org-article:f5459b37d4e643589bd0abebc63a22872021-12-02T18:02:55Z3D numerical simulation of acoustophoretic motion induced by boundary-driven acoustic streaming in standing surface acoustic wave microfluidics10.1038/s41598-021-90825-z2045-2322https://doaj.org/article/f5459b37d4e643589bd0abebc63a22872021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90825-zhttps://doaj.org/toc/2045-2322Abstract Standing surface acoustic waves (SSAWs) have been widely utilized in microfluidic devices to manipulate various cells and micro/nano-objects. Despite widespread application, a time-/cost-efficient versatile 3D model that predicts particle behavior in such platforms is still lacking. Herein, a fully-coupled 3D numerical simulation of boundary-driven acoustic streaming in the acoustofluidic devices utilizing SSAWs has been conducted based on the limiting velocity finite element method. Through this efficient computational method, the underlying physical interplay from the electromechanical fields of the piezoelectric substrate to different acoustofluidic effects (acoustic radiation force and streaming-induced drag force), fluid–solid interactions, the 3D influence of novel on-chip configuration like tilted-angle SSAW (taSSAW) based devices, required boundary conditions, meshing technique, and demanding computational cost, are discussed. As an experimental validation, a taSSAW platform fabricated on YX 128 $$^\circ $$ ∘ LiNbO3 substrate for separating polystyrene beads is simulated, which demonstrates acceptable agreement with reported experimental observations. Subsequently, as an application of the presented 3D model, a novel sheathless taSSAW cell/particle separator is conceptualized and designed. The presented 3D fully-coupled model could be considered a powerful tool in further designing and optimizing SSAW microfluidics due to the more time-/cost-efficient performance than precedented 3D models, the capability to model complex on-chip configurations, and overcome shortcomings and limitations of 2D simulations.Mohammad Sadegh NamnabatMahdi Moghimi ZandEhsan HoushfarNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mohammad Sadegh Namnabat Mahdi Moghimi Zand Ehsan Houshfar 3D numerical simulation of acoustophoretic motion induced by boundary-driven acoustic streaming in standing surface acoustic wave microfluidics
description	Abstract Standing surface acoustic waves (SSAWs) have been widely utilized in microfluidic devices to manipulate various cells and micro/nano-objects. Despite widespread application, a time-/cost-efficient versatile 3D model that predicts particle behavior in such platforms is still lacking. Herein, a fully-coupled 3D numerical simulation of boundary-driven acoustic streaming in the acoustofluidic devices utilizing SSAWs has been conducted based on the limiting velocity finite element method. Through this efficient computational method, the underlying physical interplay from the electromechanical fields of the piezoelectric substrate to different acoustofluidic effects (acoustic radiation force and streaming-induced drag force), fluid–solid interactions, the 3D influence of novel on-chip configuration like tilted-angle SSAW (taSSAW) based devices, required boundary conditions, meshing technique, and demanding computational cost, are discussed. As an experimental validation, a taSSAW platform fabricated on YX 128 $$^\circ $$ ∘ LiNbO3 substrate for separating polystyrene beads is simulated, which demonstrates acceptable agreement with reported experimental observations. Subsequently, as an application of the presented 3D model, a novel sheathless taSSAW cell/particle separator is conceptualized and designed. The presented 3D fully-coupled model could be considered a powerful tool in further designing and optimizing SSAW microfluidics due to the more time-/cost-efficient performance than precedented 3D models, the capability to model complex on-chip configurations, and overcome shortcomings and limitations of 2D simulations.
format	article
author	Mohammad Sadegh Namnabat Mahdi Moghimi Zand Ehsan Houshfar
author_facet	Mohammad Sadegh Namnabat Mahdi Moghimi Zand Ehsan Houshfar
author_sort	Mohammad Sadegh Namnabat
title	3D numerical simulation of acoustophoretic motion induced by boundary-driven acoustic streaming in standing surface acoustic wave microfluidics
title_short	3D numerical simulation of acoustophoretic motion induced by boundary-driven acoustic streaming in standing surface acoustic wave microfluidics
title_full	3D numerical simulation of acoustophoretic motion induced by boundary-driven acoustic streaming in standing surface acoustic wave microfluidics
title_fullStr	3D numerical simulation of acoustophoretic motion induced by boundary-driven acoustic streaming in standing surface acoustic wave microfluidics
title_full_unstemmed	3D numerical simulation of acoustophoretic motion induced by boundary-driven acoustic streaming in standing surface acoustic wave microfluidics
title_sort	3d numerical simulation of acoustophoretic motion induced by boundary-driven acoustic streaming in standing surface acoustic wave microfluidics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f5459b37d4e643589bd0abebc63a2287
work_keys_str_mv	AT mohammadsadeghnamnabat 3dnumericalsimulationofacoustophoreticmotioninducedbyboundarydrivenacousticstreaminginstandingsurfaceacousticwavemicrofluidics AT mahdimoghimizand 3dnumericalsimulationofacoustophoreticmotioninducedbyboundarydrivenacousticstreaminginstandingsurfaceacousticwavemicrofluidics AT ehsanhoushfar 3dnumericalsimulationofacoustophoreticmotioninducedbyboundarydrivenacousticstreaminginstandingsurfaceacousticwavemicrofluidics
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3D numerical simulation of acoustophoretic motion induced by boundary-driven acoustic streaming in standing surface acoustic wave microfluidics

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