Recovery of high specific activity molybdenum-99 from accelerator-induced fission on low-enriched uranium for technetium-99m generators

Abstract A new process was developed to recover high specific activity (no carrier added) 99Mo from electron-accelerator irradiated U3O8 or uranyl sulfate targets. The process leverages a novel solvent extraction scheme to recover Mo using di(2-ethylhexyl) phosphoric acid following uranium and trans...

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Autores principales:	M. Alex Brown, Nathan Johnson, Artem V. Gelis, Milan Stika, Anna G. Servis, Alex Bakken, Christine Krizmanich, Kristin Shannon, Peter Kozak, Amanda Barnhart, Chad Denbrock, Nicolas Luciani, Terry Grimm, Peter Tkac
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f546a3ed20ab4526b2d2e8f17031e81e
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spelling	oai:doaj.org-article:f546a3ed20ab4526b2d2e8f17031e81e2021-12-02T17:12:17ZRecovery of high specific activity molybdenum-99 from accelerator-induced fission on low-enriched uranium for technetium-99m generators10.1038/s41598-021-92704-z2045-2322https://doaj.org/article/f546a3ed20ab4526b2d2e8f17031e81e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92704-zhttps://doaj.org/toc/2045-2322Abstract A new process was developed to recover high specific activity (no carrier added) 99Mo from electron-accelerator irradiated U3O8 or uranyl sulfate targets. The process leverages a novel solvent extraction scheme to recover Mo using di(2-ethylhexyl) phosphoric acid following uranium and transuranics removal with tri-n-butyl phosphate. An anion-exchange concentration column step provides a final purification, generating pure 99Mo intended for making 99Mo/99mTc generators. The process was demonstrated with irradiated uranium targets resulting in more than 95% 99Mo recovery and without presence of fission products or actinides in the product.M. Alex BrownNathan JohnsonArtem V. GelisMilan StikaAnna G. ServisAlex BakkenChristine KrizmanichKristin ShannonPeter KozakAmanda BarnhartChad DenbrockNicolas LucianiTerry GrimmPeter TkacNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. Alex Brown Nathan Johnson Artem V. Gelis Milan Stika Anna G. Servis Alex Bakken Christine Krizmanich Kristin Shannon Peter Kozak Amanda Barnhart Chad Denbrock Nicolas Luciani Terry Grimm Peter Tkac Recovery of high specific activity molybdenum-99 from accelerator-induced fission on low-enriched uranium for technetium-99m generators
description	Abstract A new process was developed to recover high specific activity (no carrier added) 99Mo from electron-accelerator irradiated U3O8 or uranyl sulfate targets. The process leverages a novel solvent extraction scheme to recover Mo using di(2-ethylhexyl) phosphoric acid following uranium and transuranics removal with tri-n-butyl phosphate. An anion-exchange concentration column step provides a final purification, generating pure 99Mo intended for making 99Mo/99mTc generators. The process was demonstrated with irradiated uranium targets resulting in more than 95% 99Mo recovery and without presence of fission products or actinides in the product.
format	article
author	M. Alex Brown Nathan Johnson Artem V. Gelis Milan Stika Anna G. Servis Alex Bakken Christine Krizmanich Kristin Shannon Peter Kozak Amanda Barnhart Chad Denbrock Nicolas Luciani Terry Grimm Peter Tkac
author_facet	M. Alex Brown Nathan Johnson Artem V. Gelis Milan Stika Anna G. Servis Alex Bakken Christine Krizmanich Kristin Shannon Peter Kozak Amanda Barnhart Chad Denbrock Nicolas Luciani Terry Grimm Peter Tkac
author_sort	M. Alex Brown
title	Recovery of high specific activity molybdenum-99 from accelerator-induced fission on low-enriched uranium for technetium-99m generators
title_short	Recovery of high specific activity molybdenum-99 from accelerator-induced fission on low-enriched uranium for technetium-99m generators
title_full	Recovery of high specific activity molybdenum-99 from accelerator-induced fission on low-enriched uranium for technetium-99m generators
title_fullStr	Recovery of high specific activity molybdenum-99 from accelerator-induced fission on low-enriched uranium for technetium-99m generators
title_full_unstemmed	Recovery of high specific activity molybdenum-99 from accelerator-induced fission on low-enriched uranium for technetium-99m generators
title_sort	recovery of high specific activity molybdenum-99 from accelerator-induced fission on low-enriched uranium for technetium-99m generators
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f546a3ed20ab4526b2d2e8f17031e81e
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Recovery of high specific activity molybdenum-99 from accelerator-induced fission on low-enriched uranium for technetium-99m generators

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