Patterns and risk of HIV-1 transmission network among men who have sex with men in Guangxi, China
Abstract The prevalence of HIV-1 in Guangxi is very high, and the rate of HIV-1 infection among men who have sex with men (MSM) has been increasing. Therefore, it is necessary to explore the patterns and risk factors of HIV transmission in Guangxi. For this purpose, individuals diagnosed with HIV-1...
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Nature Portfolio
2021
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oai:doaj.org-article:f5498dac228440f6af56611b85b52bf62021-12-02T14:01:34ZPatterns and risk of HIV-1 transmission network among men who have sex with men in Guangxi, China10.1038/s41598-020-79951-22045-2322https://doaj.org/article/f5498dac228440f6af56611b85b52bf62021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79951-2https://doaj.org/toc/2045-2322Abstract The prevalence of HIV-1 in Guangxi is very high, and the rate of HIV-1 infection among men who have sex with men (MSM) has been increasing. Therefore, it is necessary to explore the patterns and risk factors of HIV transmission in Guangxi. For this purpose, individuals diagnosed with HIV-1 during 2013–2018 in Guangxi were recruited. Phylogenetic relationship, transmission clusters, and genotypic drug resistance analyses were performed based on HIV-1 pol sequences. Related factors were analysed to assess for their association with HIV-1 transmission. CRF07_BC (50.4%) and CRF01_AE (33.4%) were found to be the predominant subtypes. The analysed 1633 sequences (50.15%, Guangxi; 49.85%, other provinces) were segregated into 80 clusters (size per cluster, 2–704). We found that 75.3% of the individuals were in three clusters (size ˃ 100), and 73.8% were high-risk spreaders (links ≥ 4). Infection time, marital status, and subtype were significantly associated with HIV-1 transmission. Additionally, 80.2% of recent infections were linked to long-term infections, and 46.2% were linked to other provinces. A low level of transmitted drug resistance was detected (4.8%). Our findings indicated superclusters and high-risk HIV-1 spreaders among the MSM in Guangxi. Effective strategies blocking the route of transmission should be developed.Xianwu PangHui WeiJinghua HuangQin HeKailing TangNingye FangXinjuan ZhouQiuying ZhuXiuling WuGuanghua LanZhiyong ShenMei LinShujia LiangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Xianwu Pang Hui Wei Jinghua Huang Qin He Kailing Tang Ningye Fang Xinjuan Zhou Qiuying Zhu Xiuling Wu Guanghua Lan Zhiyong Shen Mei Lin Shujia Liang Patterns and risk of HIV-1 transmission network among men who have sex with men in Guangxi, China |
| description |
Abstract The prevalence of HIV-1 in Guangxi is very high, and the rate of HIV-1 infection among men who have sex with men (MSM) has been increasing. Therefore, it is necessary to explore the patterns and risk factors of HIV transmission in Guangxi. For this purpose, individuals diagnosed with HIV-1 during 2013–2018 in Guangxi were recruited. Phylogenetic relationship, transmission clusters, and genotypic drug resistance analyses were performed based on HIV-1 pol sequences. Related factors were analysed to assess for their association with HIV-1 transmission. CRF07_BC (50.4%) and CRF01_AE (33.4%) were found to be the predominant subtypes. The analysed 1633 sequences (50.15%, Guangxi; 49.85%, other provinces) were segregated into 80 clusters (size per cluster, 2–704). We found that 75.3% of the individuals were in three clusters (size ˃ 100), and 73.8% were high-risk spreaders (links ≥ 4). Infection time, marital status, and subtype were significantly associated with HIV-1 transmission. Additionally, 80.2% of recent infections were linked to long-term infections, and 46.2% were linked to other provinces. A low level of transmitted drug resistance was detected (4.8%). Our findings indicated superclusters and high-risk HIV-1 spreaders among the MSM in Guangxi. Effective strategies blocking the route of transmission should be developed. |
| format |
article |
| author |
Xianwu Pang Hui Wei Jinghua Huang Qin He Kailing Tang Ningye Fang Xinjuan Zhou Qiuying Zhu Xiuling Wu Guanghua Lan Zhiyong Shen Mei Lin Shujia Liang |
| author_facet |
Xianwu Pang Hui Wei Jinghua Huang Qin He Kailing Tang Ningye Fang Xinjuan Zhou Qiuying Zhu Xiuling Wu Guanghua Lan Zhiyong Shen Mei Lin Shujia Liang |
| author_sort |
Xianwu Pang |
| title |
Patterns and risk of HIV-1 transmission network among men who have sex with men in Guangxi, China |
| title_short |
Patterns and risk of HIV-1 transmission network among men who have sex with men in Guangxi, China |
| title_full |
Patterns and risk of HIV-1 transmission network among men who have sex with men in Guangxi, China |
| title_fullStr |
Patterns and risk of HIV-1 transmission network among men who have sex with men in Guangxi, China |
| title_full_unstemmed |
Patterns and risk of HIV-1 transmission network among men who have sex with men in Guangxi, China |
| title_sort |
patterns and risk of hiv-1 transmission network among men who have sex with men in guangxi, china |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/f5498dac228440f6af56611b85b52bf6 |
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