Polymorphism of gene UBE2E2 and the risk of developing diabetes type 2

Recently, the ubiquitin–proteasome pathway has emerged as a crucial pathway for protein turnover, and it has also been identified as an important factor for insulin synthesis. This pathway plays a critical role inside β cells; therefore, it has naturally been linked with various insulin-related dise...

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Autores principales:	Elena Vladimirovna Kazakova, Yanhui Wu, Meijun Chen, Tongtong Wang, Lulu Sun, Hong Qiao
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2015
Materias:	type 2 diabetes mellitus ube2e2 single nucleotide polymorphism genetic predisposition Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/f5512cc52fd84030a59ae51bec849c79
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spelling	oai:doaj.org-article:f5512cc52fd84030a59ae51bec849c792021-11-14T09:00:20ZPolymorphism of gene UBE2E2 and the risk of developing diabetes type 22072-03512072-037810.14341/DM2015346-50https://doaj.org/article/f5512cc52fd84030a59ae51bec849c792015-10-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6856https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Recently, the ubiquitin–proteasome pathway has emerged as a crucial pathway for protein turnover, and it has also been identified as an important factor for insulin synthesis. This pathway plays a critical role inside β cells; therefore, it has naturally been linked with various insulin-related diseases, most notably type 2 diabetes mellitus (T2DM), but also other metabolic diseases and symptoms such as obesity and atherosclerotic plaques. The UBE2E2 gene encodes ubiquitin-conjugating enzyme E2 E2 (UBE2E2), which plays an important role in the synthesis and secretion of insulin. UBE2E2 is a protein expressed in the pancreas, liver, and adipose tissue, as well as in an insulin-secreting cell line . The results of some studies have indicated that single nucleotide polymorphisms on UBE2E2 (rs6780569, rs7612463, rs9812056) are associated with T2DM risk in Japanese, Korean and Chinese populations. Therefore, the UBE2E2 gene has started to draw interest from researchers because of its newly discovered relationships with various diseases.Elena Vladimirovna KazakovaYanhui WuMeijun ChenTongtong WangLulu SunHong QiaoEndocrinology Research Centrearticletype 2 diabetes mellitusube2e2single nucleotide polymorphismgenetic predispositionNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 18, Iss 3, Pp 46-50 (2015)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 2 diabetes mellitus ube2e2 single nucleotide polymorphism genetic predisposition Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 2 diabetes mellitus ube2e2 single nucleotide polymorphism genetic predisposition Nutritional diseases. Deficiency diseases RC620-627 Elena Vladimirovna Kazakova Yanhui Wu Meijun Chen Tongtong Wang Lulu Sun Hong Qiao Polymorphism of gene UBE2E2 and the risk of developing diabetes type 2
description	Recently, the ubiquitin–proteasome pathway has emerged as a crucial pathway for protein turnover, and it has also been identified as an important factor for insulin synthesis. This pathway plays a critical role inside β cells; therefore, it has naturally been linked with various insulin-related diseases, most notably type 2 diabetes mellitus (T2DM), but also other metabolic diseases and symptoms such as obesity and atherosclerotic plaques. The UBE2E2 gene encodes ubiquitin-conjugating enzyme E2 E2 (UBE2E2), which plays an important role in the synthesis and secretion of insulin. UBE2E2 is a protein expressed in the pancreas, liver, and adipose tissue, as well as in an insulin-secreting cell line . The results of some studies have indicated that single nucleotide polymorphisms on UBE2E2 (rs6780569, rs7612463, rs9812056) are associated with T2DM risk in Japanese, Korean and Chinese populations. Therefore, the UBE2E2 gene has started to draw interest from researchers because of its newly discovered relationships with various diseases.
format	article
author	Elena Vladimirovna Kazakova Yanhui Wu Meijun Chen Tongtong Wang Lulu Sun Hong Qiao
author_facet	Elena Vladimirovna Kazakova Yanhui Wu Meijun Chen Tongtong Wang Lulu Sun Hong Qiao
author_sort	Elena Vladimirovna Kazakova
title	Polymorphism of gene UBE2E2 and the risk of developing diabetes type 2
title_short	Polymorphism of gene UBE2E2 and the risk of developing diabetes type 2
title_full	Polymorphism of gene UBE2E2 and the risk of developing diabetes type 2
title_fullStr	Polymorphism of gene UBE2E2 and the risk of developing diabetes type 2
title_full_unstemmed	Polymorphism of gene UBE2E2 and the risk of developing diabetes type 2
title_sort	polymorphism of gene ube2e2 and the risk of developing diabetes type 2
publisher	Endocrinology Research Centre
publishDate	2015
url	https://doaj.org/article/f5512cc52fd84030a59ae51bec849c79
work_keys_str_mv	AT elenavladimirovnakazakova polymorphismofgeneube2e2andtheriskofdevelopingdiabetestype2 AT yanhuiwu polymorphismofgeneube2e2andtheriskofdevelopingdiabetestype2 AT meijunchen polymorphismofgeneube2e2andtheriskofdevelopingdiabetestype2 AT tongtongwang polymorphismofgeneube2e2andtheriskofdevelopingdiabetestype2 AT lulusun polymorphismofgeneube2e2andtheriskofdevelopingdiabetestype2 AT hongqiao polymorphismofgeneube2e2andtheriskofdevelopingdiabetestype2
_version_	1718429565286612992

Polymorphism of gene UBE2E2 and the risk of developing diabetes type 2

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