The Ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model

Although the permeation mechanisms for K+ and Na+ channels have been extensively studied, the ion permeation mechanism through Ca2+ channels was largely unknown. Here the authors develop a multisite Ca2+ model that can be used in the framework of classical MD simulations to study Ca2+ in a quantitat...

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Autores principales:	Aihua Zhang, Hua Yu, Chunhong Liu, Chen Song
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f55196e6cf0f477e937e78a85ea0e7bb
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spelling	oai:doaj.org-article:f55196e6cf0f477e937e78a85ea0e7bb2021-12-02T17:32:27ZThe Ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model10.1038/s41467-020-14573-w2041-1723https://doaj.org/article/f55196e6cf0f477e937e78a85ea0e7bb2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14573-whttps://doaj.org/toc/2041-1723Although the permeation mechanisms for K+ and Na+ channels have been extensively studied, the ion permeation mechanism through Ca2+ channels was largely unknown. Here the authors develop a multisite Ca2+ model that can be used in the framework of classical MD simulations to study Ca2+ in a quantitative manner, and use it to investigate the ion permeation mechanism of the ryanodine receptor 1.Aihua ZhangHua YuChunhong LiuChen SongNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aihua Zhang Hua Yu Chunhong Liu Chen Song The Ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model
description	Although the permeation mechanisms for K+ and Na+ channels have been extensively studied, the ion permeation mechanism through Ca2+ channels was largely unknown. Here the authors develop a multisite Ca2+ model that can be used in the framework of classical MD simulations to study Ca2+ in a quantitative manner, and use it to investigate the ion permeation mechanism of the ryanodine receptor 1.
format	article
author	Aihua Zhang Hua Yu Chunhong Liu Chen Song
author_facet	Aihua Zhang Hua Yu Chunhong Liu Chen Song
author_sort	Aihua Zhang
title	The Ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model
title_short	The Ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model
title_full	The Ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model
title_fullStr	The Ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model
title_full_unstemmed	The Ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model
title_sort	ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f55196e6cf0f477e937e78a85ea0e7bb
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The Ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model

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