White matter tract-specific alterations in patients with primary restless legs syndrome

Abstract Prior diffusion tensor imaging (DTI) studies have investigated white matter (WM) changes in patients with primary restless legs syndrome (RLS), but the results were inconsistent. Here, we proposed using tract-specific statistical analysis (TSSA) to find alterations in specific WM tracts to...

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Autores principales:	Hea Ree Park, Hye Ryun Kim, Seunghwan Oh, Joon-Kyung Seong, Eun Yeon Joo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f55233b1c4f5482cbc6a37bb3d630b2f
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spelling	oai:doaj.org-article:f55233b1c4f5482cbc6a37bb3d630b2f2021-12-02T18:50:53ZWhite matter tract-specific alterations in patients with primary restless legs syndrome10.1038/s41598-021-95238-62045-2322https://doaj.org/article/f55233b1c4f5482cbc6a37bb3d630b2f2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95238-6https://doaj.org/toc/2045-2322Abstract Prior diffusion tensor imaging (DTI) studies have investigated white matter (WM) changes in patients with primary restless legs syndrome (RLS), but the results were inconsistent. Here, we proposed using tract-specific statistical analysis (TSSA) to find alterations in specific WM tracts to clarify the pathophysiological mechanisms of RLS. We enrolled 30 patients with RLS and 31 age- and sex- matched controls who underwent brain magnetic resonance imaging, neuropsychological tests, and polysomnography. Fractional anisotropy (FA) maps obtained from whole-brain diffusion tensor imaging and TSSA were used to localize WM changes in patients with RLS. Subsequently, a comparison of FA values for each tract between patients and controls was performed. The associations between FA values and clinical, polysomnographic, and neuropsychological parameters in RLS patients were assessed. RLS patients demonstrated decreased FA values in the left corticospinal tract (CST) and cingulum, and in the right anterior thalamic radiation (ATR) and inferior fronto-occipital fasciculus (IFO). Patients’ attention/executive function and visual memory scores positively correlated with FA values in the right ATR, and anxiety levels negatively correlated with FA values in the right IFO. Additionally, the number of periodic leg movements and movement arousal index were negatively correlated with FA values in the left CST. The TSSA method identified previously unknown tract-specific alterations in patients with RLS and significant associations with distinct clinical manifestations of RLS.Hea Ree ParkHye Ryun KimSeunghwan OhJoon-Kyung SeongEun Yeon JooNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hea Ree Park Hye Ryun Kim Seunghwan Oh Joon-Kyung Seong Eun Yeon Joo White matter tract-specific alterations in patients with primary restless legs syndrome
description	Abstract Prior diffusion tensor imaging (DTI) studies have investigated white matter (WM) changes in patients with primary restless legs syndrome (RLS), but the results were inconsistent. Here, we proposed using tract-specific statistical analysis (TSSA) to find alterations in specific WM tracts to clarify the pathophysiological mechanisms of RLS. We enrolled 30 patients with RLS and 31 age- and sex- matched controls who underwent brain magnetic resonance imaging, neuropsychological tests, and polysomnography. Fractional anisotropy (FA) maps obtained from whole-brain diffusion tensor imaging and TSSA were used to localize WM changes in patients with RLS. Subsequently, a comparison of FA values for each tract between patients and controls was performed. The associations between FA values and clinical, polysomnographic, and neuropsychological parameters in RLS patients were assessed. RLS patients demonstrated decreased FA values in the left corticospinal tract (CST) and cingulum, and in the right anterior thalamic radiation (ATR) and inferior fronto-occipital fasciculus (IFO). Patients’ attention/executive function and visual memory scores positively correlated with FA values in the right ATR, and anxiety levels negatively correlated with FA values in the right IFO. Additionally, the number of periodic leg movements and movement arousal index were negatively correlated with FA values in the left CST. The TSSA method identified previously unknown tract-specific alterations in patients with RLS and significant associations with distinct clinical manifestations of RLS.
format	article
author	Hea Ree Park Hye Ryun Kim Seunghwan Oh Joon-Kyung Seong Eun Yeon Joo
author_facet	Hea Ree Park Hye Ryun Kim Seunghwan Oh Joon-Kyung Seong Eun Yeon Joo
author_sort	Hea Ree Park
title	White matter tract-specific alterations in patients with primary restless legs syndrome
title_short	White matter tract-specific alterations in patients with primary restless legs syndrome
title_full	White matter tract-specific alterations in patients with primary restless legs syndrome
title_fullStr	White matter tract-specific alterations in patients with primary restless legs syndrome
title_full_unstemmed	White matter tract-specific alterations in patients with primary restless legs syndrome
title_sort	white matter tract-specific alterations in patients with primary restless legs syndrome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f55233b1c4f5482cbc6a37bb3d630b2f
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White matter tract-specific alterations in patients with primary restless legs syndrome

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