Association Between Lack of Insight and Prefrontal Serotonin Transporter Availability in Antipsychotic-Free Patients with Schizophrenia: A High-Resolution PET Study with [11C]DASB

Jeong-Hee Kim,1,2 Young-Don Son,1– 3 Hang-Keun Kim,1– 3 Jong-Hoon Kim1,3,4 1Neuroscience Research Institute, Gachon University, Incheon, Republic of Korea; 2Department of Biomedical Engineering, College of Health Science, Gachon University, Incheon, Republic of Korea; 3Gachon Advanced Institute for...

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Autores principales:	Kim JH, Son YD, Kim HK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	insight schizophrenia serotonin transporter prefrontal cortex [11c]dasb positron emission tomography Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f55bab2593e148ed9091286fdcfe0d72
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id	oai:doaj.org-article:f55bab2593e148ed9091286fdcfe0d72
record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN
topic	insight schizophrenia serotonin transporter prefrontal cortex [11c]dasb positron emission tomography Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	insight schizophrenia serotonin transporter prefrontal cortex [11c]dasb positron emission tomography Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Kim JH Son YD Kim HK Kim JH Association Between Lack of Insight and Prefrontal Serotonin Transporter Availability in Antipsychotic-Free Patients with Schizophrenia: A High-Resolution PET Study with [11C]DASB
description	Jeong-Hee Kim,1,2 Young-Don Son,1– 3 Hang-Keun Kim,1– 3 Jong-Hoon Kim1,3,4 1Neuroscience Research Institute, Gachon University, Incheon, Republic of Korea; 2Department of Biomedical Engineering, College of Health Science, Gachon University, Incheon, Republic of Korea; 3Gachon Advanced Institute for Health Sciences & Technology, Gachon University, Incheon, Republic of Korea; 4Department of Psychiatry, Gachon University College of Medicine, Gil Medical Center, Incheon, Republic of KoreaCorrespondence: Jong-Hoon KimDepartment of Psychiatry, Gachon University College of Medicine, Gil Medical Center, 1198 Guwol-dong, Namdong-gu, Incheon, 21565, Republic of KoreaTel +82 32 460 2696Fax +82 32 472 8813Email jhnp@chol.com; jhnp@gachon.ac.krYoung-Don SonDepartment of Biomedical Engineering, College of Health Science, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon, 21936, Republic of KoreaTel +82 32 820 4416Email ydson@gachon.ac.krBackground: Previous studies suggested a link between serotonergic neurotransmission and impaired insight in schizophrenia. In this study, we examined the relationship between serotonin transporter (SERT) availability in regions of the prefrontal cortex (dorsolateral, ventrolateral, ventromedial, and orbitofrontal cortices) and insight deficits in antipsychotic-free patients with schizophrenia using high-resolution positron emission tomography (PET) with [11C]DASB.Methods: Nineteen patients underwent [11C]DASB PET and 7-Tesla magnetic resonance imaging scans. To assess SERT availability, the binding potential with respect to non-displaceable compartment (BPND) was derived using the simplified reference tissue model. Patients’ level of insight was assessed using the Insight and Treatment Attitude Questionnaire (ITAQ). The relationship between ITAQ scores and [11C]DASB BPND values was examined using the region-of-interest (ROI)- and voxel-based analyses with relevant variables as covariates. The prefrontal cortex and its four subregions were selected as a priori ROIs since the prefrontal cortex has been implicated as the critical neuroanatomical substrate of impaired insight in schizophrenia.Results: The ROI-based analysis revealed that the ITAQ illness insight dimension had significant negative correlations with the [11C]DASB BPND in the left dorsolateral, left orbitofrontal, and bilateral ventrolateral prefrontal cortices. The ITAQ treatment insight dimension had significant negative correlations with the [11C]DASB BPND in the bilateral dorsolateral, left orbitofrontal, and bilateral ventrolateral prefrontal cortices. The ITAQ total score showed significant negative correlations with the [11C]DASB BPND in the bilateral prefrontal cortex and three subregions (dorsolateral, ventrolateral, and orbitofrontal cortices). A supplementary voxel-based analysis corroborated a significant negative association between the ITAQ score and the [11C]DASB BPND in the prefrontal cortices.Conclusion: Our study provides in vivo evidence of significant negative correlations between insight deficits and prefrontal SERT availability in patients with schizophrenia, suggesting significant involvement of prefrontal serotonergic signaling in impaired insight, one of the core symptoms of schizophrenia.Keywords: insight, schizophrenia, serotonin transporter, prefrontal cortex, [11C]DASB, positron emission tomography
format	article
author	Kim JH Son YD Kim HK Kim JH
author_facet	Kim JH Son YD Kim HK Kim JH
author_sort	Kim JH
title	Association Between Lack of Insight and Prefrontal Serotonin Transporter Availability in Antipsychotic-Free Patients with Schizophrenia: A High-Resolution PET Study with [11C]DASB
title_short	Association Between Lack of Insight and Prefrontal Serotonin Transporter Availability in Antipsychotic-Free Patients with Schizophrenia: A High-Resolution PET Study with [11C]DASB
title_full	Association Between Lack of Insight and Prefrontal Serotonin Transporter Availability in Antipsychotic-Free Patients with Schizophrenia: A High-Resolution PET Study with [11C]DASB
title_fullStr	Association Between Lack of Insight and Prefrontal Serotonin Transporter Availability in Antipsychotic-Free Patients with Schizophrenia: A High-Resolution PET Study with [11C]DASB
title_full_unstemmed	Association Between Lack of Insight and Prefrontal Serotonin Transporter Availability in Antipsychotic-Free Patients with Schizophrenia: A High-Resolution PET Study with [11C]DASB
title_sort	association between lack of insight and prefrontal serotonin transporter availability in antipsychotic-free patients with schizophrenia: a high-resolution pet study with [11c]dasb
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/f55bab2593e148ed9091286fdcfe0d72
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spelling	oai:doaj.org-article:f55bab2593e148ed9091286fdcfe0d722021-12-02T19:36:07ZAssociation Between Lack of Insight and Prefrontal Serotonin Transporter Availability in Antipsychotic-Free Patients with Schizophrenia: A High-Resolution PET Study with [11C]DASB1178-2021https://doaj.org/article/f55bab2593e148ed9091286fdcfe0d722021-10-01T00:00:00Zhttps://www.dovepress.com/association-between-lack-of-insight-and-prefrontal-serotonin-transport-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Jeong-Hee Kim,1,2 Young-Don Son,1– 3 Hang-Keun Kim,1– 3 Jong-Hoon Kim1,3,4 1Neuroscience Research Institute, Gachon University, Incheon, Republic of Korea; 2Department of Biomedical Engineering, College of Health Science, Gachon University, Incheon, Republic of Korea; 3Gachon Advanced Institute for Health Sciences & Technology, Gachon University, Incheon, Republic of Korea; 4Department of Psychiatry, Gachon University College of Medicine, Gil Medical Center, Incheon, Republic of KoreaCorrespondence: Jong-Hoon KimDepartment of Psychiatry, Gachon University College of Medicine, Gil Medical Center, 1198 Guwol-dong, Namdong-gu, Incheon, 21565, Republic of KoreaTel +82 32 460 2696Fax +82 32 472 8813Email jhnp@chol.com; jhnp@gachon.ac.krYoung-Don SonDepartment of Biomedical Engineering, College of Health Science, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon, 21936, Republic of KoreaTel +82 32 820 4416Email ydson@gachon.ac.krBackground: Previous studies suggested a link between serotonergic neurotransmission and impaired insight in schizophrenia. In this study, we examined the relationship between serotonin transporter (SERT) availability in regions of the prefrontal cortex (dorsolateral, ventrolateral, ventromedial, and orbitofrontal cortices) and insight deficits in antipsychotic-free patients with schizophrenia using high-resolution positron emission tomography (PET) with [11C]DASB.Methods: Nineteen patients underwent [11C]DASB PET and 7-Tesla magnetic resonance imaging scans. To assess SERT availability, the binding potential with respect to non-displaceable compartment (BPND) was derived using the simplified reference tissue model. Patients’ level of insight was assessed using the Insight and Treatment Attitude Questionnaire (ITAQ). The relationship between ITAQ scores and [11C]DASB BPND values was examined using the region-of-interest (ROI)- and voxel-based analyses with relevant variables as covariates. The prefrontal cortex and its four subregions were selected as a priori ROIs since the prefrontal cortex has been implicated as the critical neuroanatomical substrate of impaired insight in schizophrenia.Results: The ROI-based analysis revealed that the ITAQ illness insight dimension had significant negative correlations with the [11C]DASB BPND in the left dorsolateral, left orbitofrontal, and bilateral ventrolateral prefrontal cortices. The ITAQ treatment insight dimension had significant negative correlations with the [11C]DASB BPND in the bilateral dorsolateral, left orbitofrontal, and bilateral ventrolateral prefrontal cortices. The ITAQ total score showed significant negative correlations with the [11C]DASB BPND in the bilateral prefrontal cortex and three subregions (dorsolateral, ventrolateral, and orbitofrontal cortices). A supplementary voxel-based analysis corroborated a significant negative association between the ITAQ score and the [11C]DASB BPND in the prefrontal cortices.Conclusion: Our study provides in vivo evidence of significant negative correlations between insight deficits and prefrontal SERT availability in patients with schizophrenia, suggesting significant involvement of prefrontal serotonergic signaling in impaired insight, one of the core symptoms of schizophrenia.Keywords: insight, schizophrenia, serotonin transporter, prefrontal cortex, [11C]DASB, positron emission tomographyKim JHSon YDKim HKKim JHDove Medical Pressarticleinsightschizophreniaserotonin transporterprefrontal cortex[11c]dasbpositron emission tomographyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 3195-3203 (2021)

Association Between Lack of Insight and Prefrontal Serotonin Transporter Availability in Antipsychotic-Free Patients with Schizophrenia: A High-Resolution PET Study with [11C]DASB

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