The danger is growing! A new paradigm for immune system activation and peripheral tolerance.

Successful immune defense is a complex balancing act. In order to protect a host against invasion by harmful pathogens, an immune response must be rapid and vigorous, and must eliminate foreign invaders before their populations grow beyond control. That same immune response, however, must be selecti...

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Autores principales:	Sharon Bewick, Ruoting Yang, Mingjun Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f55cfe16c1f8474595b003e0d656c501
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spelling	oai:doaj.org-article:f55cfe16c1f8474595b003e0d656c5012021-11-25T06:27:38ZThe danger is growing! A new paradigm for immune system activation and peripheral tolerance.1932-620310.1371/journal.pone.0008112https://doaj.org/article/f55cfe16c1f8474595b003e0d656c5012009-12-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19956616/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Successful immune defense is a complex balancing act. In order to protect a host against invasion by harmful pathogens, an immune response must be rapid and vigorous, and must eliminate foreign invaders before their populations grow beyond control. That same immune response, however, must be selective enough to recognize and ignore commensal bacteria, environmental antigens and host tissue itself. How the immune system makes the crucial decision whether or not to attack a particular antigen has been a long-standing question central to the study of immunology. Here we show that the structure of the signaling network between regulatory T-cells and type 17 helper T-cells allows the immune system to selectively attack pathogens based on whether or not the pathogens represent a growing, and thus dangerous population. We term this mechanism for immune system activation the 'Growth Detection Paradigm', because it offers an entirely new explanation for immune system regulation and peripheral tolerance.Sharon BewickRuoting YangMingjun ZhangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 12, p e8112 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sharon Bewick Ruoting Yang Mingjun Zhang The danger is growing! A new paradigm for immune system activation and peripheral tolerance.
description	Successful immune defense is a complex balancing act. In order to protect a host against invasion by harmful pathogens, an immune response must be rapid and vigorous, and must eliminate foreign invaders before their populations grow beyond control. That same immune response, however, must be selective enough to recognize and ignore commensal bacteria, environmental antigens and host tissue itself. How the immune system makes the crucial decision whether or not to attack a particular antigen has been a long-standing question central to the study of immunology. Here we show that the structure of the signaling network between regulatory T-cells and type 17 helper T-cells allows the immune system to selectively attack pathogens based on whether or not the pathogens represent a growing, and thus dangerous population. We term this mechanism for immune system activation the 'Growth Detection Paradigm', because it offers an entirely new explanation for immune system regulation and peripheral tolerance.
format	article
author	Sharon Bewick Ruoting Yang Mingjun Zhang
author_facet	Sharon Bewick Ruoting Yang Mingjun Zhang
author_sort	Sharon Bewick
title	The danger is growing! A new paradigm for immune system activation and peripheral tolerance.
title_short	The danger is growing! A new paradigm for immune system activation and peripheral tolerance.
title_full	The danger is growing! A new paradigm for immune system activation and peripheral tolerance.
title_fullStr	The danger is growing! A new paradigm for immune system activation and peripheral tolerance.
title_full_unstemmed	The danger is growing! A new paradigm for immune system activation and peripheral tolerance.
title_sort	danger is growing! a new paradigm for immune system activation and peripheral tolerance.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/f55cfe16c1f8474595b003e0d656c501
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The danger is growing! A new paradigm for immune system activation and peripheral tolerance.

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