Structural basis of ECF-σ-factor-dependent transcription initiation

No structural data have been available for RNA polymerase holoenzymes or transcription initiation complexes that contain extracytoplasmic σ factors. Here the authors report the crystal structures of transcription initiation complexes comprising Mycobacterium tuberculosis RNA polymerase, extracytopla...

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Autores principales: Wei Lin, Sukhendu Mandal, David Degen, Min Sung Cho, Yu Feng, Kalyan Das, Richard H. Ebright
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/f55e90aaf41f47288c3b2ad96204bc88
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Sumario:No structural data have been available for RNA polymerase holoenzymes or transcription initiation complexes that contain extracytoplasmic σ factors. Here the authors report the crystal structures of transcription initiation complexes comprising Mycobacterium tuberculosis RNA polymerase, extracytoplasmic σ factor σL and promoter DNA.