Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth

The availability of nutrients within the tumour microenvironment can influence tumour growth. Here, the authors find that, in a melanoma mouse model, mice fed a high glutamine diet have reduced tumour growth, increased sensitivity to Braf inhibitors and elevated a-ketoglutarate levels.

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Autores principales:	Mari B. Ishak Gabra, Ying Yang, Haiqing Li, Parijat Senapati, Eric A. Hanse, Xazmin H. Lowman, Thai Q. Tran, Lishi Zhang, Linda T. Doan, Xiangdong Xu, Dustin E. Schones, David A. Fruman, Mei Kong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f55f7d0478ab4cf7851235354cd349ce
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spelling	oai:doaj.org-article:f55f7d0478ab4cf7851235354cd349ce2021-12-02T14:34:06ZDietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth10.1038/s41467-020-17181-w2041-1723https://doaj.org/article/f55f7d0478ab4cf7851235354cd349ce2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17181-whttps://doaj.org/toc/2041-1723The availability of nutrients within the tumour microenvironment can influence tumour growth. Here, the authors find that, in a melanoma mouse model, mice fed a high glutamine diet have reduced tumour growth, increased sensitivity to Braf inhibitors and elevated a-ketoglutarate levels.Mari B. Ishak GabraYing YangHaiqing LiParijat SenapatiEric A. HanseXazmin H. LowmanThai Q. TranLishi ZhangLinda T. DoanXiangdong XuDustin E. SchonesDavid A. FrumanMei KongNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mari B. Ishak Gabra Ying Yang Haiqing Li Parijat Senapati Eric A. Hanse Xazmin H. Lowman Thai Q. Tran Lishi Zhang Linda T. Doan Xiangdong Xu Dustin E. Schones David A. Fruman Mei Kong Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth
description	The availability of nutrients within the tumour microenvironment can influence tumour growth. Here, the authors find that, in a melanoma mouse model, mice fed a high glutamine diet have reduced tumour growth, increased sensitivity to Braf inhibitors and elevated a-ketoglutarate levels.
format	article
author	Mari B. Ishak Gabra Ying Yang Haiqing Li Parijat Senapati Eric A. Hanse Xazmin H. Lowman Thai Q. Tran Lishi Zhang Linda T. Doan Xiangdong Xu Dustin E. Schones David A. Fruman Mei Kong
author_facet	Mari B. Ishak Gabra Ying Yang Haiqing Li Parijat Senapati Eric A. Hanse Xazmin H. Lowman Thai Q. Tran Lishi Zhang Linda T. Doan Xiangdong Xu Dustin E. Schones David A. Fruman Mei Kong
author_sort	Mari B. Ishak Gabra
title	Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth
title_short	Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth
title_full	Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth
title_fullStr	Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth
title_full_unstemmed	Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth
title_sort	dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f55f7d0478ab4cf7851235354cd349ce
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Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth

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