p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

Dysregulation of p62 has been implicated in tumorigenesis. Here, the authors show that p62 promotes hepatocellular carcinoma by reprogramming glucose and glutamine metabolism through Nrf2 and present a novel compound that can inhibit p62 action thus sensitizing cancer cells to chemotherapy.

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Autores principales: Tetsuya Saito, Yoshinobu Ichimura, Keiko Taguchi, Takafumi Suzuki, Tsunehiro Mizushima, Kenji Takagi, Yuki Hirose, Masayuki Nagahashi, Tetsuro Iso, Toshiaki Fukutomi, Maki Ohishi, Keiko Endo, Takefumi Uemura, Yasumasa Nishito, Shujiro Okuda, Miki Obata, Tsuguka Kouno, Riyo Imamura, Yukio Tada, Rika Obata, Daisuke Yasuda, Kyoko Takahashi, Tsutomu Fujimura, Jingbo Pi, Myung-Shik Lee, Takashi Ueno, Tomoyuki Ohe, Tadahiko Mashino, Toshifumi Wakai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Hozumi Motohashi, Satoshi Waguri, Tomoyoshi Soga, Masayuki Yamamoto, Keiji Tanaka, Masaaki Komatsu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/f562794e07c0466a84d8f58624fb3b55
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spelling oai:doaj.org-article:f562794e07c0466a84d8f58624fb3b552021-12-02T14:39:14Zp62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming10.1038/ncomms120302041-1723https://doaj.org/article/f562794e07c0466a84d8f58624fb3b552016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms12030https://doaj.org/toc/2041-1723Dysregulation of p62 has been implicated in tumorigenesis. Here, the authors show that p62 promotes hepatocellular carcinoma by reprogramming glucose and glutamine metabolism through Nrf2 and present a novel compound that can inhibit p62 action thus sensitizing cancer cells to chemotherapy.Tetsuya SaitoYoshinobu IchimuraKeiko TaguchiTakafumi SuzukiTsunehiro MizushimaKenji TakagiYuki HiroseMasayuki NagahashiTetsuro IsoToshiaki FukutomiMaki OhishiKeiko EndoTakefumi UemuraYasumasa NishitoShujiro OkudaMiki ObataTsuguka KounoRiyo ImamuraYukio TadaRika ObataDaisuke YasudaKyoko TakahashiTsutomu FujimuraJingbo PiMyung-Shik LeeTakashi UenoTomoyuki OheTadahiko MashinoToshifumi WakaiHirotatsu KojimaTakayoshi OkabeTetsuo NaganoHozumi MotohashiSatoshi WaguriTomoyoshi SogaMasayuki YamamotoKeiji TanakaMasaaki KomatsuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tetsuya Saito
Yoshinobu Ichimura
Keiko Taguchi
Takafumi Suzuki
Tsunehiro Mizushima
Kenji Takagi
Yuki Hirose
Masayuki Nagahashi
Tetsuro Iso
Toshiaki Fukutomi
Maki Ohishi
Keiko Endo
Takefumi Uemura
Yasumasa Nishito
Shujiro Okuda
Miki Obata
Tsuguka Kouno
Riyo Imamura
Yukio Tada
Rika Obata
Daisuke Yasuda
Kyoko Takahashi
Tsutomu Fujimura
Jingbo Pi
Myung-Shik Lee
Takashi Ueno
Tomoyuki Ohe
Tadahiko Mashino
Toshifumi Wakai
Hirotatsu Kojima
Takayoshi Okabe
Tetsuo Nagano
Hozumi Motohashi
Satoshi Waguri
Tomoyoshi Soga
Masayuki Yamamoto
Keiji Tanaka
Masaaki Komatsu
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
description Dysregulation of p62 has been implicated in tumorigenesis. Here, the authors show that p62 promotes hepatocellular carcinoma by reprogramming glucose and glutamine metabolism through Nrf2 and present a novel compound that can inhibit p62 action thus sensitizing cancer cells to chemotherapy.
format article
author Tetsuya Saito
Yoshinobu Ichimura
Keiko Taguchi
Takafumi Suzuki
Tsunehiro Mizushima
Kenji Takagi
Yuki Hirose
Masayuki Nagahashi
Tetsuro Iso
Toshiaki Fukutomi
Maki Ohishi
Keiko Endo
Takefumi Uemura
Yasumasa Nishito
Shujiro Okuda
Miki Obata
Tsuguka Kouno
Riyo Imamura
Yukio Tada
Rika Obata
Daisuke Yasuda
Kyoko Takahashi
Tsutomu Fujimura
Jingbo Pi
Myung-Shik Lee
Takashi Ueno
Tomoyuki Ohe
Tadahiko Mashino
Toshifumi Wakai
Hirotatsu Kojima
Takayoshi Okabe
Tetsuo Nagano
Hozumi Motohashi
Satoshi Waguri
Tomoyoshi Soga
Masayuki Yamamoto
Keiji Tanaka
Masaaki Komatsu
author_facet Tetsuya Saito
Yoshinobu Ichimura
Keiko Taguchi
Takafumi Suzuki
Tsunehiro Mizushima
Kenji Takagi
Yuki Hirose
Masayuki Nagahashi
Tetsuro Iso
Toshiaki Fukutomi
Maki Ohishi
Keiko Endo
Takefumi Uemura
Yasumasa Nishito
Shujiro Okuda
Miki Obata
Tsuguka Kouno
Riyo Imamura
Yukio Tada
Rika Obata
Daisuke Yasuda
Kyoko Takahashi
Tsutomu Fujimura
Jingbo Pi
Myung-Shik Lee
Takashi Ueno
Tomoyuki Ohe
Tadahiko Mashino
Toshifumi Wakai
Hirotatsu Kojima
Takayoshi Okabe
Tetsuo Nagano
Hozumi Motohashi
Satoshi Waguri
Tomoyoshi Soga
Masayuki Yamamoto
Keiji Tanaka
Masaaki Komatsu
author_sort Tetsuya Saito
title p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
title_short p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
title_full p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
title_fullStr p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
title_full_unstemmed p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
title_sort p62/sqstm1 promotes malignancy of hcv-positive hepatocellular carcinoma through nrf2-dependent metabolic reprogramming
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/f562794e07c0466a84d8f58624fb3b55
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