Clinical effect of lymphocyte immunotherapy on patients with unexplained recurrent spontaneous abortion

Abstract Introduction Lymphocyte immunotherapy (LIT) is believed to be a viable treatment for unexplained recurrent spontaneous abortion (URSA), but its effect remains controversial. This study aims to investigate the clinical effect of LIT in patients with URSA and clarify the factors that may infl...

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Autores principales:	Sudong Liu, Xiaodong Gu, Ruiqiang Weng
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	blocking antibody (BA) live birth rate lymphocyte immunotherapy (LIT) unexplained recurrent spontaneous abortion (URSA) Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/f56433f4d85b4e2ab3a9d3eb2ba68e6c
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spelling	oai:doaj.org-article:f56433f4d85b4e2ab3a9d3eb2ba68e6c2021-11-12T19:57:14ZClinical effect of lymphocyte immunotherapy on patients with unexplained recurrent spontaneous abortion2050-452710.1002/iid3.474https://doaj.org/article/f56433f4d85b4e2ab3a9d3eb2ba68e6c2021-12-01T00:00:00Zhttps://doi.org/10.1002/iid3.474https://doaj.org/toc/2050-4527Abstract Introduction Lymphocyte immunotherapy (LIT) is believed to be a viable treatment for unexplained recurrent spontaneous abortion (URSA), but its effect remains controversial. This study aims to investigate the clinical effect of LIT in patients with URSA and clarify the factors that may influence the outcome of LIT. Methods This study included a total of 704 URSA patients, of which 444 patients accepted LIT treatment. URSA patients that did not accept LIT served as control group. Clinical characteristics were collected and analyzed between LIT and control group. The blocking antibody was tested before and after LIT. The outcome of LIT treatment was recorded. Logistic regression analysis was applied to evaluate the independent predictors of LIT success. Results After LIT treatment, 77.9% (346/444) of USRA patients turned to BA positive, and the conversion rate elevated with increased LIT (p < .001). LIT significantly improved the pregnancy rate and live birth rate in USRA patients (65.3% vs. 29.6%, p < .001; 80.3% vs. 50.6%, p < .001). Multivariate regression analysis suggested that younger maternal age and positive BA were independent predictors of LIT success. Conclusion LIT effectively induced the production of BA, and improved pregnancy rate and live birth rate in URSA patients. Our findings supported LIT as a beneficial treatment for URSA.Sudong LiuXiaodong GuRuiqiang WengWileyarticleblocking antibody (BA)live birth ratelymphocyte immunotherapy (LIT)unexplained recurrent spontaneous abortion (URSA)Immunologic diseases. AllergyRC581-607ENImmunity, Inflammation and Disease, Vol 9, Iss 4, Pp 1272-1278 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	blocking antibody (BA) live birth rate lymphocyte immunotherapy (LIT) unexplained recurrent spontaneous abortion (URSA) Immunologic diseases. Allergy RC581-607
spellingShingle	blocking antibody (BA) live birth rate lymphocyte immunotherapy (LIT) unexplained recurrent spontaneous abortion (URSA) Immunologic diseases. Allergy RC581-607 Sudong Liu Xiaodong Gu Ruiqiang Weng Clinical effect of lymphocyte immunotherapy on patients with unexplained recurrent spontaneous abortion
description	Abstract Introduction Lymphocyte immunotherapy (LIT) is believed to be a viable treatment for unexplained recurrent spontaneous abortion (URSA), but its effect remains controversial. This study aims to investigate the clinical effect of LIT in patients with URSA and clarify the factors that may influence the outcome of LIT. Methods This study included a total of 704 URSA patients, of which 444 patients accepted LIT treatment. URSA patients that did not accept LIT served as control group. Clinical characteristics were collected and analyzed between LIT and control group. The blocking antibody was tested before and after LIT. The outcome of LIT treatment was recorded. Logistic regression analysis was applied to evaluate the independent predictors of LIT success. Results After LIT treatment, 77.9% (346/444) of USRA patients turned to BA positive, and the conversion rate elevated with increased LIT (p < .001). LIT significantly improved the pregnancy rate and live birth rate in USRA patients (65.3% vs. 29.6%, p < .001; 80.3% vs. 50.6%, p < .001). Multivariate regression analysis suggested that younger maternal age and positive BA were independent predictors of LIT success. Conclusion LIT effectively induced the production of BA, and improved pregnancy rate and live birth rate in URSA patients. Our findings supported LIT as a beneficial treatment for URSA.
format	article
author	Sudong Liu Xiaodong Gu Ruiqiang Weng
author_facet	Sudong Liu Xiaodong Gu Ruiqiang Weng
author_sort	Sudong Liu
title	Clinical effect of lymphocyte immunotherapy on patients with unexplained recurrent spontaneous abortion
title_short	Clinical effect of lymphocyte immunotherapy on patients with unexplained recurrent spontaneous abortion
title_full	Clinical effect of lymphocyte immunotherapy on patients with unexplained recurrent spontaneous abortion
title_fullStr	Clinical effect of lymphocyte immunotherapy on patients with unexplained recurrent spontaneous abortion
title_full_unstemmed	Clinical effect of lymphocyte immunotherapy on patients with unexplained recurrent spontaneous abortion
title_sort	clinical effect of lymphocyte immunotherapy on patients with unexplained recurrent spontaneous abortion
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/f56433f4d85b4e2ab3a9d3eb2ba68e6c
work_keys_str_mv	AT sudongliu clinicaleffectoflymphocyteimmunotherapyonpatientswithunexplainedrecurrentspontaneousabortion AT xiaodonggu clinicaleffectoflymphocyteimmunotherapyonpatientswithunexplainedrecurrentspontaneousabortion AT ruiqiangweng clinicaleffectoflymphocyteimmunotherapyonpatientswithunexplainedrecurrentspontaneousabortion
_version_	1718430350131068928

Clinical effect of lymphocyte immunotherapy on patients with unexplained recurrent spontaneous abortion

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