Gene-Activated Matrix with Self-Assembly Anionic Nano-Device Containing Plasmid DNAs for Rat Cranial Bone Augmentation

Gene-Activated Matrix with Self-Assembly Anionic Nano-Device Containing Plasmid DNAs for Rat Cranial Bone Augmentation

We have developed nanoballs, a biocompatible self-assembly nano-vector based on electrostatic interactions that arrange anionic macromolecules to polymeric nanomaterials to create nucleic acid carriers. Nanoballs exhibit low cytotoxicity and high transfection efficiently in vivo. This study investig...

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Détails bibliographiques
Auteurs principaux: Masahito Hara, Yoshinori Sumita, Yukinobu Kodama, Mayumi Iwatake, Hideyuki Yamamoto, Rena Shido, Shun Narahara, Takunori Ogaeri, Hitoshi Sasaki, Izumi Asahina
Format: article
Langue:EN
Publié: MDPI AG 2021
Sujets:
bone augmentation
in vivo gene delivery
gene-activated matrix
plasmid vector
self-assembly nano-device
Technology
T
Electrical engineering. Electronics. Nuclear engineering
TK1-9971
Engineering (General). Civil engineering (General)
TA1-2040
Microscopy
QH201-278.5
Descriptive and experimental mechanics
QC120-168.85
Accès en ligne:https://doaj.org/article/f565e59bc16c48db8245e49dc5e5ee38
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https://doaj.org/article/f565e59bc16c48db8245e49dc5e5ee38

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