Comparison of two laboratory-based systems for evaluation of halos in intraocular lenses

Daniel Carson,* Sangyeol Lee,* Elsinore Alexander, Xin Wei, Shinwook Lee Alcon Research, Ltd., Fort Worth, TX, USA *These authors contributed equally to this work Purpose: Multifocal intraocular lenses (IOLs) can be associated with unwanted visual phenomena, including halos. Predicting potential...

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Autores principales:	Carson D, Lee S, Alexander E, Wei X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	visual disturbance high dynamic range quantitative metric multifocal IOL Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/f5669837c7c542e5a2a07dbf245a4734
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spelling	oai:doaj.org-article:f5669837c7c542e5a2a07dbf245a47342021-12-02T03:56:43ZComparison of two laboratory-based systems for evaluation of halos in intraocular lenses1177-5483https://doaj.org/article/f5669837c7c542e5a2a07dbf245a47342018-02-01T00:00:00Zhttps://www.dovepress.com/comparison-of-two-laboratory-based-systems-for-evaluation-of-halos-in--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Daniel Carson,* Sangyeol Lee,* Elsinore Alexander, Xin Wei, Shinwook Lee Alcon Research, Ltd., Fort Worth, TX, USA *These authors contributed equally to this work Purpose: Multifocal intraocular lenses (IOLs) can be associated with unwanted visual phenomena, including halos. Predicting potential for halos is desirable when designing new multifocal IOLs. Halo images from 6 IOL models were compared using the Optikos modulation transfer function bench system and a new high dynamic range (HDR) system.Materials and methods: One monofocal, 1 extended depth of focus, and 4 multifocal IOLs were evaluated. An off-the-shelf optical bench was used to simulate a distant (>50 m) car headlight and record images. A custom HDR system was constructed using an imaging photometer to simulate headlight images and to measure quantitative halo luminance data. A metric was developed to characterize halo luminance properties. Clinical relevance was investigated by correlating halo measurements to visual outcomes questionnaire data.Results: The Optikos system produced halo images useful for visual comparisons; however, measurements were relative and not quantitative. The HDR halo system provided objective and quantitative measurements used to create a metric from the area under the curve (AUC) of the logarithmic normalized halo profile. This proposed metric differentiated between IOL models, and linear regression analysis found strong correlations between AUC and subjective clinical ratings of halos.Conclusion: The HDR system produced quantitative, preclinical metrics that correlated to patients’ subjective perception of halos. Keywords: visual disturbance, high dynamic range, quantitative metric, multifocal IOL Carson DLee SAlexander EWei XLee SDove Medical Pressarticlevisual disturbancehigh dynamic rangequantitative metricmultifocal IOLOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 385-393 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	visual disturbance high dynamic range quantitative metric multifocal IOL Ophthalmology RE1-994
spellingShingle	visual disturbance high dynamic range quantitative metric multifocal IOL Ophthalmology RE1-994 Carson D Lee S Alexander E Wei X Lee S Comparison of two laboratory-based systems for evaluation of halos in intraocular lenses
description	Daniel Carson,* Sangyeol Lee,* Elsinore Alexander, Xin Wei, Shinwook Lee Alcon Research, Ltd., Fort Worth, TX, USA *These authors contributed equally to this work Purpose: Multifocal intraocular lenses (IOLs) can be associated with unwanted visual phenomena, including halos. Predicting potential for halos is desirable when designing new multifocal IOLs. Halo images from 6 IOL models were compared using the Optikos modulation transfer function bench system and a new high dynamic range (HDR) system.Materials and methods: One monofocal, 1 extended depth of focus, and 4 multifocal IOLs were evaluated. An off-the-shelf optical bench was used to simulate a distant (>50 m) car headlight and record images. A custom HDR system was constructed using an imaging photometer to simulate headlight images and to measure quantitative halo luminance data. A metric was developed to characterize halo luminance properties. Clinical relevance was investigated by correlating halo measurements to visual outcomes questionnaire data.Results: The Optikos system produced halo images useful for visual comparisons; however, measurements were relative and not quantitative. The HDR halo system provided objective and quantitative measurements used to create a metric from the area under the curve (AUC) of the logarithmic normalized halo profile. This proposed metric differentiated between IOL models, and linear regression analysis found strong correlations between AUC and subjective clinical ratings of halos.Conclusion: The HDR system produced quantitative, preclinical metrics that correlated to patients’ subjective perception of halos. Keywords: visual disturbance, high dynamic range, quantitative metric, multifocal IOL
format	article
author	Carson D Lee S Alexander E Wei X Lee S
author_facet	Carson D Lee S Alexander E Wei X Lee S
author_sort	Carson D
title	Comparison of two laboratory-based systems for evaluation of halos in intraocular lenses
title_short	Comparison of two laboratory-based systems for evaluation of halos in intraocular lenses
title_full	Comparison of two laboratory-based systems for evaluation of halos in intraocular lenses
title_fullStr	Comparison of two laboratory-based systems for evaluation of halos in intraocular lenses
title_full_unstemmed	Comparison of two laboratory-based systems for evaluation of halos in intraocular lenses
title_sort	comparison of two laboratory-based systems for evaluation of halos in intraocular lenses
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/f5669837c7c542e5a2a07dbf245a4734
work_keys_str_mv	AT carsond comparisonoftwolaboratorybasedsystemsforevaluationofhalosinintraocularlenses AT lees comparisonoftwolaboratorybasedsystemsforevaluationofhalosinintraocularlenses AT alexandere comparisonoftwolaboratorybasedsystemsforevaluationofhalosinintraocularlenses AT weix comparisonoftwolaboratorybasedsystemsforevaluationofhalosinintraocularlenses AT lees comparisonoftwolaboratorybasedsystemsforevaluationofhalosinintraocularlenses
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Comparison of two laboratory-based systems for evaluation of halos in intraocular lenses

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