Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer

Background: Magnetic Particle Imaging (MPI) is an emerging imaging modality for quantitative direct imaging of superparamagnetic iron oxide nanoparticles (SPION or SPIO). With different physics from MRI, MPI benefits from ideal image contrast with zero background tissue signal. This enables clear vi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhi Wei Tay, Prashant Chandrasekharan, Benjamin D. Fellows, Irati Rodrigo Arrizabalaga, Elaine Yu, Malini Olivo, Steven M. Conolly
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	magnetic particle imaging magnetic nanoparticles magnetic hyperthermia magnetic drug delivery Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/f567e5ebee1c496c8386b691cec211ff
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f567e5ebee1c496c8386b691cec211ff
record_format	dspace
spelling	oai:doaj.org-article:f567e5ebee1c496c8386b691cec211ff2021-11-11T15:27:08ZMagnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer10.3390/cancers132152852072-6694https://doaj.org/article/f567e5ebee1c496c8386b691cec211ff2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5285https://doaj.org/toc/2072-6694Background: Magnetic Particle Imaging (MPI) is an emerging imaging modality for quantitative direct imaging of superparamagnetic iron oxide nanoparticles (SPION or SPIO). With different physics from MRI, MPI benefits from ideal image contrast with zero background tissue signal. This enables clear visualization of cancer with image characteristics similar to PET or SPECT, but using radiation-free magnetic nanoparticles instead, with infinite-duration reporter persistence in vivo. MPI for cancer imaging: demonstrated months of quantitative imaging of the cancer-related immune response with in situ SPION-labelling of immune cells (e.g., neutrophils, CAR T-cells). Because MPI suffers absolutely no susceptibility artifacts in the lung, immuno-MPI could soon provide completely noninvasive early-stage diagnosis and treatment monitoring of lung cancers. MPI for magnetic steering: MPI gradients are ~150 × stronger than MRI, enabling remote magnetic steering of magneto-aerosol, nanoparticles, and catheter tips, enhancing therapeutic delivery by magnetic means. MPI for precision therapy: gradients enable focusing of magnetic hyperthermia and magnetic-actuated drug release with up to 2 mm precision. The extent of drug release from the magnetic nanocarrier can be quantitatively monitored by MPI of SPION’s MPS spectral changes within the nanocarrier. Conclusion: MPI is a promising new magnetic modality spanning cancer imaging to guided-therapy.Zhi Wei TayPrashant ChandrasekharanBenjamin D. FellowsIrati Rodrigo ArrizabalagaElaine YuMalini OlivoSteven M. ConollyMDPI AGarticlemagnetic particle imagingmagnetic nanoparticlesmagnetic hyperthermiamagnetic drug deliveryNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5285, p 5285 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnetic particle imaging magnetic nanoparticles magnetic hyperthermia magnetic drug delivery Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	magnetic particle imaging magnetic nanoparticles magnetic hyperthermia magnetic drug delivery Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Zhi Wei Tay Prashant Chandrasekharan Benjamin D. Fellows Irati Rodrigo Arrizabalaga Elaine Yu Malini Olivo Steven M. Conolly Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer
description	Background: Magnetic Particle Imaging (MPI) is an emerging imaging modality for quantitative direct imaging of superparamagnetic iron oxide nanoparticles (SPION or SPIO). With different physics from MRI, MPI benefits from ideal image contrast with zero background tissue signal. This enables clear visualization of cancer with image characteristics similar to PET or SPECT, but using radiation-free magnetic nanoparticles instead, with infinite-duration reporter persistence in vivo. MPI for cancer imaging: demonstrated months of quantitative imaging of the cancer-related immune response with in situ SPION-labelling of immune cells (e.g., neutrophils, CAR T-cells). Because MPI suffers absolutely no susceptibility artifacts in the lung, immuno-MPI could soon provide completely noninvasive early-stage diagnosis and treatment monitoring of lung cancers. MPI for magnetic steering: MPI gradients are ~150 × stronger than MRI, enabling remote magnetic steering of magneto-aerosol, nanoparticles, and catheter tips, enhancing therapeutic delivery by magnetic means. MPI for precision therapy: gradients enable focusing of magnetic hyperthermia and magnetic-actuated drug release with up to 2 mm precision. The extent of drug release from the magnetic nanocarrier can be quantitatively monitored by MPI of SPION’s MPS spectral changes within the nanocarrier. Conclusion: MPI is a promising new magnetic modality spanning cancer imaging to guided-therapy.
format	article
author	Zhi Wei Tay Prashant Chandrasekharan Benjamin D. Fellows Irati Rodrigo Arrizabalaga Elaine Yu Malini Olivo Steven M. Conolly
author_facet	Zhi Wei Tay Prashant Chandrasekharan Benjamin D. Fellows Irati Rodrigo Arrizabalaga Elaine Yu Malini Olivo Steven M. Conolly
author_sort	Zhi Wei Tay
title	Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer
title_short	Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer
title_full	Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer
title_fullStr	Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer
title_full_unstemmed	Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer
title_sort	magnetic particle imaging: an emerging modality with prospects in diagnosis, targeting and therapy of cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f567e5ebee1c496c8386b691cec211ff
work_keys_str_mv	AT zhiweitay magneticparticleimaginganemergingmodalitywithprospectsindiagnosistargetingandtherapyofcancer AT prashantchandrasekharan magneticparticleimaginganemergingmodalitywithprospectsindiagnosistargetingandtherapyofcancer AT benjamindfellows magneticparticleimaginganemergingmodalitywithprospectsindiagnosistargetingandtherapyofcancer AT iratirodrigoarrizabalaga magneticparticleimaginganemergingmodalitywithprospectsindiagnosistargetingandtherapyofcancer AT elaineyu magneticparticleimaginganemergingmodalitywithprospectsindiagnosistargetingandtherapyofcancer AT maliniolivo magneticparticleimaginganemergingmodalitywithprospectsindiagnosistargetingandtherapyofcancer AT stevenmconolly magneticparticleimaginganemergingmodalitywithprospectsindiagnosistargetingandtherapyofcancer
_version_	1718435280295297024

Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer

Ejemplares similares