Comparative study of proteasome inhibitory, synergistic antibacterial, synergistic anticandidal, and antioxidant activities of gold nanoparticles biosynthesized using fruit waste materials

Jayanta Kumar Patra,1 Kwang-Hyun Baek2 1Research Institute of Biotechnology and Medical Converged Science, Dongguk University-Seoul, Ilsandong-gu, Gyeonggi-do, 2Department of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, South Korea Abstract: The aim of this study was to compare the bi...

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Autores principales:	Patra JK, Baek KH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Antibacterial anticandidal antioxidant Cucumis melo gold nanoparticles proteasome inhibitor Prunus persica Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f5688153781e40ae942b5fd90bc0ff91
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spelling	oai:doaj.org-article:f5688153781e40ae942b5fd90bc0ff912021-12-02T02:10:31ZComparative study of proteasome inhibitory, synergistic antibacterial, synergistic anticandidal, and antioxidant activities of gold nanoparticles biosynthesized using fruit waste materials1178-2013https://doaj.org/article/f5688153781e40ae942b5fd90bc0ff912016-09-01T00:00:00Zhttps://www.dovepress.com/comparative-study-of-proteasome-inhibitory-synergistic-antibacterial-s-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jayanta Kumar Patra,1 Kwang-Hyun Baek2 1Research Institute of Biotechnology and Medical Converged Science, Dongguk University-Seoul, Ilsandong-gu, Gyeonggi-do, 2Department of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, South Korea Abstract: The aim of this study was to compare the biological synthesis of gold nanoparticles (AuNPs) generated using the aqueous extracts of outer oriental melon peel (OMP) and peach. The synthesized OMP-AuNPs and peach extract (PE)-AuNPs were characterized by ultraviolet–visible spectroscopy, field emission scanning electron microscopy, energy dispersive X-ray analysis, X-ray powder diffraction, Fourier transform infrared spectroscopy, and thermogravimetric analysis. The surface plasmon resonance spectra were obtained at 545 nm and 540 nm for OMP-AuNPs and PE-AuNPs, respectively. The estimated absolute crystallite size of the synthesized AuNPs was calculated to be 78.11 nm for OMP-AuNPs and 39.90 nm for PE-AuNPs based on the Scherer equation of the X-ray powder diffraction peaks. Fourier transform infrared spectroscopy results revealed the involvement of bioactive compounds present in OMP and peach extracts in the synthesis and stabilization of synthesized AuNPs. Both the OMP-AuNPs and PE-AuNPs showed a strong antibacterial synergistic activity when combined with kanamycin (9.38–20.45 mm inhibition zones) and rifampicin (9.52–25.23 mm inhibition zones), and they also exerted a strong synergistic anticandidal activity (10.09–15.47 mm inhibition zones) when combined with amphotericin B against five pathogenic Candida species. Both the OMP-AuNPs and PE-AuNPs exhibited a strong antioxidant potential in terms of 1,1-diphenyl-2-picrylhydraxyl radical scavenging, nitric oxide scavenging, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radical scavenging, and a reducing power, along with a strong proteasome inhibitory potential that could be useful in cancer drug delivery and cancer treatments. The PE-AuNPs showed comparatively higher activity than OMP-AuNPs, which could be attributed to the presence of rich bioactive compounds in the PE that acted as reducing and capping agents in the synthesis of PE-AuNPs. Overall, the results of the current investigation highlighted a novel green technology for the synthesis of AuNPs using food waste materials and their potential applications in the biomedical, pharmaceutical, and cosmetic industries. Keywords: antibacterial, anticandidal, antioxidant, Cucumis melo, gold nanoparticles, proteasome inhibitor, Prunus persicaPatra JKBaek KHDove Medical PressarticleAntibacterialanticandidalantioxidantCucumis melogold nanoparticlesproteasome inhibitorPrunus persicaMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 4691-4705 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antibacterial anticandidal antioxidant Cucumis melo gold nanoparticles proteasome inhibitor Prunus persica Medicine (General) R5-920
spellingShingle	Antibacterial anticandidal antioxidant Cucumis melo gold nanoparticles proteasome inhibitor Prunus persica Medicine (General) R5-920 Patra JK Baek KH Comparative study of proteasome inhibitory, synergistic antibacterial, synergistic anticandidal, and antioxidant activities of gold nanoparticles biosynthesized using fruit waste materials
description	Jayanta Kumar Patra,1 Kwang-Hyun Baek2 1Research Institute of Biotechnology and Medical Converged Science, Dongguk University-Seoul, Ilsandong-gu, Gyeonggi-do, 2Department of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, South Korea Abstract: The aim of this study was to compare the biological synthesis of gold nanoparticles (AuNPs) generated using the aqueous extracts of outer oriental melon peel (OMP) and peach. The synthesized OMP-AuNPs and peach extract (PE)-AuNPs were characterized by ultraviolet–visible spectroscopy, field emission scanning electron microscopy, energy dispersive X-ray analysis, X-ray powder diffraction, Fourier transform infrared spectroscopy, and thermogravimetric analysis. The surface plasmon resonance spectra were obtained at 545 nm and 540 nm for OMP-AuNPs and PE-AuNPs, respectively. The estimated absolute crystallite size of the synthesized AuNPs was calculated to be 78.11 nm for OMP-AuNPs and 39.90 nm for PE-AuNPs based on the Scherer equation of the X-ray powder diffraction peaks. Fourier transform infrared spectroscopy results revealed the involvement of bioactive compounds present in OMP and peach extracts in the synthesis and stabilization of synthesized AuNPs. Both the OMP-AuNPs and PE-AuNPs showed a strong antibacterial synergistic activity when combined with kanamycin (9.38–20.45 mm inhibition zones) and rifampicin (9.52–25.23 mm inhibition zones), and they also exerted a strong synergistic anticandidal activity (10.09–15.47 mm inhibition zones) when combined with amphotericin B against five pathogenic Candida species. Both the OMP-AuNPs and PE-AuNPs exhibited a strong antioxidant potential in terms of 1,1-diphenyl-2-picrylhydraxyl radical scavenging, nitric oxide scavenging, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radical scavenging, and a reducing power, along with a strong proteasome inhibitory potential that could be useful in cancer drug delivery and cancer treatments. The PE-AuNPs showed comparatively higher activity than OMP-AuNPs, which could be attributed to the presence of rich bioactive compounds in the PE that acted as reducing and capping agents in the synthesis of PE-AuNPs. Overall, the results of the current investigation highlighted a novel green technology for the synthesis of AuNPs using food waste materials and their potential applications in the biomedical, pharmaceutical, and cosmetic industries. Keywords: antibacterial, anticandidal, antioxidant, Cucumis melo, gold nanoparticles, proteasome inhibitor, Prunus persica
format	article
author	Patra JK Baek KH
author_facet	Patra JK Baek KH
author_sort	Patra JK
title	Comparative study of proteasome inhibitory, synergistic antibacterial, synergistic anticandidal, and antioxidant activities of gold nanoparticles biosynthesized using fruit waste materials
title_short	Comparative study of proteasome inhibitory, synergistic antibacterial, synergistic anticandidal, and antioxidant activities of gold nanoparticles biosynthesized using fruit waste materials
title_full	Comparative study of proteasome inhibitory, synergistic antibacterial, synergistic anticandidal, and antioxidant activities of gold nanoparticles biosynthesized using fruit waste materials
title_fullStr	Comparative study of proteasome inhibitory, synergistic antibacterial, synergistic anticandidal, and antioxidant activities of gold nanoparticles biosynthesized using fruit waste materials
title_full_unstemmed	Comparative study of proteasome inhibitory, synergistic antibacterial, synergistic anticandidal, and antioxidant activities of gold nanoparticles biosynthesized using fruit waste materials
title_sort	comparative study of proteasome inhibitory, synergistic antibacterial, synergistic anticandidal, and antioxidant activities of gold nanoparticles biosynthesized using fruit waste materials
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/f5688153781e40ae942b5fd90bc0ff91
work_keys_str_mv	AT patrajk comparativestudyofproteasomeinhibitorysynergisticantibacterialsynergisticanticandidalandantioxidantactivitiesofgoldnanoparticlesbiosynthesizedusingfruitwastematerials AT baekkh comparativestudyofproteasomeinhibitorysynergisticantibacterialsynergisticanticandidalandantioxidantactivitiesofgoldnanoparticlesbiosynthesizedusingfruitwastematerials
_version_	1718402687552192512

Comparative study of proteasome inhibitory, synergistic antibacterial, synergistic anticandidal, and antioxidant activities of gold nanoparticles biosynthesized using fruit waste materials

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