Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10

Expanded RNA repeats in non-coding region of a gene represent a hallmark of several diseases. Here, the authors identify two small molecules that selectively bind AU repeats and use them to design a compound that targets the pathogenic RNA associated with spinocerebellar ataxia type 10.

Guardado en:

Detalles Bibliográficos
Autores principales:	Wang-Yong Yang, Rui Gao, Mark Southern, Partha S. Sarkar, Matthew D. Disney
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f56a67cc0b8b4f9395ec9cf105810314
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f56a67cc0b8b4f9395ec9cf105810314
record_format	dspace
spelling	oai:doaj.org-article:f56a67cc0b8b4f9395ec9cf1058103142021-12-02T17:32:52ZDesign of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 1010.1038/ncomms116472041-1723https://doaj.org/article/f56a67cc0b8b4f9395ec9cf1058103142016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11647https://doaj.org/toc/2041-1723Expanded RNA repeats in non-coding region of a gene represent a hallmark of several diseases. Here, the authors identify two small molecules that selectively bind AU repeats and use them to design a compound that targets the pathogenic RNA associated with spinocerebellar ataxia type 10.Wang-Yong YangRui GaoMark SouthernPartha S. SarkarMatthew D. DisneyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wang-Yong Yang Rui Gao Mark Southern Partha S. Sarkar Matthew D. Disney Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10
description	Expanded RNA repeats in non-coding region of a gene represent a hallmark of several diseases. Here, the authors identify two small molecules that selectively bind AU repeats and use them to design a compound that targets the pathogenic RNA associated with spinocerebellar ataxia type 10.
format	article
author	Wang-Yong Yang Rui Gao Mark Southern Partha S. Sarkar Matthew D. Disney
author_facet	Wang-Yong Yang Rui Gao Mark Southern Partha S. Sarkar Matthew D. Disney
author_sort	Wang-Yong Yang
title	Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10
title_short	Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10
title_full	Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10
title_fullStr	Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10
title_full_unstemmed	Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10
title_sort	design of a bioactive small molecule that targets r(auucu) repeats in spinocerebellar ataxia 10
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f56a67cc0b8b4f9395ec9cf105810314
work_keys_str_mv	AT wangyongyang designofabioactivesmallmoleculethattargetsrauucurepeatsinspinocerebellarataxia10 AT ruigao designofabioactivesmallmoleculethattargetsrauucurepeatsinspinocerebellarataxia10 AT marksouthern designofabioactivesmallmoleculethattargetsrauucurepeatsinspinocerebellarataxia10 AT parthassarkar designofabioactivesmallmoleculethattargetsrauucurepeatsinspinocerebellarataxia10 AT matthewddisney designofabioactivesmallmoleculethattargetsrauucurepeatsinspinocerebellarataxia10
_version_	1718380159265931264

Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10

Ejemplares similares