Time to regain birth weight - a marker to predict the severity of retinopathy of prematurity?

Abstract Background Poor weight gain in the first few weeks of life has been studied as a predictor of retinopathy of prematurity (ROP). Our aim was to assess whether time taken to regain birthweight (BW) be used as an additional marker to identify infants with type 1 ROP. Methods In this retrospect...

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Autores principales:	Ajay Anvekar, Sam Athikarisamy, Shripada Rao, Andy Gill, Elizabeth Nathan, Dorota Doherty, Geoffrey Lam
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Preterm Birth weight Retinopathy of prematurity Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/f56a9a972b234a52aa4092980bff3481
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spelling	oai:doaj.org-article:f56a9a972b234a52aa4092980bff34812021-12-05T12:21:21ZTime to regain birth weight - a marker to predict the severity of retinopathy of prematurity?10.1186/s12887-021-03027-x1471-2431https://doaj.org/article/f56a9a972b234a52aa4092980bff34812021-12-01T00:00:00Zhttps://doi.org/10.1186/s12887-021-03027-xhttps://doaj.org/toc/1471-2431Abstract Background Poor weight gain in the first few weeks of life has been studied as a predictor of retinopathy of prematurity (ROP). Our aim was to assess whether time taken to regain birthweight (BW) be used as an additional marker to identify infants with type 1 ROP. Methods In this retrospective study, preterm infants (< 27 weeks gestational age at birth) born during the period from 1/1/2010–31/12/2015 at a tertiary neonatal intensive care unit in Australia were included. Twenty-seven preterm infants with Type 1 ROP were identified. Controls (No ROP or ROP other than type 1) were matched with cases on gestational age at birth and BW (1:4 ratio). Data were collected from the database and medical records. Results The median (IQR) gestational age for Type 1 ROP and control groups were 24 (24–26) and 25 (24–26) weeks respectively and median (IQR) BW for Type 1 ROP and control groups were 675 (635–810) and 773 (666–884) grams respectively. Preterm infants with Type 1 ROP were more likely to be small for gestational age (SGA) (18.5% vs 3.7%, p = 0.015) and had increased weeks on oxygen therapy (median 11.9 vs 9.1, p = 0.028). Time to regain BW was longer in preterm infants with type 1 ROP than controls but did not reach statistical significance (median 9 vs 7 days, OR 1.08, 95% CI 1.00–1.17, p = 0.059) adjusted for SGA and duration of oxygen therapy. The area under the curve from the time to regain BW model with adjustment for SGA and duration of oxygen therapy was 0.73 (95% CI 0.62–0.83). Conclusion We hypothesize that time to regain BW has potential to aid prediction of Type 1 ROP and this warrants further investigation in a larger prospective study.Ajay AnvekarSam AthikarisamyShripada RaoAndy GillElizabeth NathanDorota DohertyGeoffrey LamBMCarticlePretermBirth weightRetinopathy of prematurityPediatricsRJ1-570ENBMC Pediatrics, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Preterm Birth weight Retinopathy of prematurity Pediatrics RJ1-570
spellingShingle	Preterm Birth weight Retinopathy of prematurity Pediatrics RJ1-570 Ajay Anvekar Sam Athikarisamy Shripada Rao Andy Gill Elizabeth Nathan Dorota Doherty Geoffrey Lam Time to regain birth weight - a marker to predict the severity of retinopathy of prematurity?
description	Abstract Background Poor weight gain in the first few weeks of life has been studied as a predictor of retinopathy of prematurity (ROP). Our aim was to assess whether time taken to regain birthweight (BW) be used as an additional marker to identify infants with type 1 ROP. Methods In this retrospective study, preterm infants (< 27 weeks gestational age at birth) born during the period from 1/1/2010–31/12/2015 at a tertiary neonatal intensive care unit in Australia were included. Twenty-seven preterm infants with Type 1 ROP were identified. Controls (No ROP or ROP other than type 1) were matched with cases on gestational age at birth and BW (1:4 ratio). Data were collected from the database and medical records. Results The median (IQR) gestational age for Type 1 ROP and control groups were 24 (24–26) and 25 (24–26) weeks respectively and median (IQR) BW for Type 1 ROP and control groups were 675 (635–810) and 773 (666–884) grams respectively. Preterm infants with Type 1 ROP were more likely to be small for gestational age (SGA) (18.5% vs 3.7%, p = 0.015) and had increased weeks on oxygen therapy (median 11.9 vs 9.1, p = 0.028). Time to regain BW was longer in preterm infants with type 1 ROP than controls but did not reach statistical significance (median 9 vs 7 days, OR 1.08, 95% CI 1.00–1.17, p = 0.059) adjusted for SGA and duration of oxygen therapy. The area under the curve from the time to regain BW model with adjustment for SGA and duration of oxygen therapy was 0.73 (95% CI 0.62–0.83). Conclusion We hypothesize that time to regain BW has potential to aid prediction of Type 1 ROP and this warrants further investigation in a larger prospective study.
format	article
author	Ajay Anvekar Sam Athikarisamy Shripada Rao Andy Gill Elizabeth Nathan Dorota Doherty Geoffrey Lam
author_facet	Ajay Anvekar Sam Athikarisamy Shripada Rao Andy Gill Elizabeth Nathan Dorota Doherty Geoffrey Lam
author_sort	Ajay Anvekar
title	Time to regain birth weight - a marker to predict the severity of retinopathy of prematurity?
title_short	Time to regain birth weight - a marker to predict the severity of retinopathy of prematurity?
title_full	Time to regain birth weight - a marker to predict the severity of retinopathy of prematurity?
title_fullStr	Time to regain birth weight - a marker to predict the severity of retinopathy of prematurity?
title_full_unstemmed	Time to regain birth weight - a marker to predict the severity of retinopathy of prematurity?
title_sort	time to regain birth weight - a marker to predict the severity of retinopathy of prematurity?
publisher	BMC
publishDate	2021
url	https://doaj.org/article/f56a9a972b234a52aa4092980bff3481
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Time to regain birth weight - a marker to predict the severity of retinopathy of prematurity?

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