Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)
A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:f56aa12424184b2093ef7db929b89a6f2021-12-02T00:34:03ZBone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)1664-239210.3389/fendo.2021.720728https://doaj.org/article/f56aa12424184b2093ef7db929b89a6f2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.720728/fullhttps://doaj.org/toc/1664-2392A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals – including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing –omics data in order to advance musculoskeletal research and move towards “personalised medicine”.Ines FoesslJ. H. Duncan BassettÅshild BjørneremÅshild BjørneremBjörn BusseÂngelo CaladoPascale ChavassieuxMaria ChristouEleni DouniEleni DouniImke A. K. FiedlerJoão Eurico FonsecaJoão Eurico FonsecaEva HasslerWolfgang HöglerErika KagueDavid KarasikPatricia KhashayarBente L. LangdahlVictoria D. LeitchPhilippe LopesGeorgios MarkozannesFiona E. A. McGuiganCarolina Medina-GomezEvangelia NtzaniEvangelia NtzaniLing OeiClaes OhlssonClaes OhlssonPawel SzulcJonathan H. TobiasJonathan H. TobiasKaterina TrajanoskaŞansın TuzunAmina ValjevacBert van RietbergenGraham R. WilliamsTatjana ZekicFernando RivadeneiraBarbara Obermayer-PietschFrontiers Media S.A.articlebone and skeletal diseasesphenotypingimaginganimal modelsGEMSTONECOSTDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021) |
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bone and skeletal diseases phenotyping imaging animal models GEMSTONE COST Diseases of the endocrine glands. Clinical endocrinology RC648-665 |
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bone and skeletal diseases phenotyping imaging animal models GEMSTONE COST Diseases of the endocrine glands. Clinical endocrinology RC648-665 Ines Foessl J. H. Duncan Bassett Åshild Bjørnerem Åshild Bjørnerem Björn Busse Ângelo Calado Pascale Chavassieux Maria Christou Eleni Douni Eleni Douni Imke A. K. Fiedler João Eurico Fonseca João Eurico Fonseca Eva Hassler Wolfgang Högler Erika Kague David Karasik Patricia Khashayar Bente L. Langdahl Victoria D. Leitch Philippe Lopes Georgios Markozannes Fiona E. A. McGuigan Carolina Medina-Gomez Evangelia Ntzani Evangelia Ntzani Ling Oei Claes Ohlsson Claes Ohlsson Pawel Szulc Jonathan H. Tobias Jonathan H. Tobias Katerina Trajanoska Şansın Tuzun Amina Valjevac Bert van Rietbergen Graham R. Williams Tatjana Zekic Fernando Rivadeneira Barbara Obermayer-Pietsch Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”) |
| description |
A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals – including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing –omics data in order to advance musculoskeletal research and move towards “personalised medicine”. |
| format |
article |
| author |
Ines Foessl J. H. Duncan Bassett Åshild Bjørnerem Åshild Bjørnerem Björn Busse Ângelo Calado Pascale Chavassieux Maria Christou Eleni Douni Eleni Douni Imke A. K. Fiedler João Eurico Fonseca João Eurico Fonseca Eva Hassler Wolfgang Högler Erika Kague David Karasik Patricia Khashayar Bente L. Langdahl Victoria D. Leitch Philippe Lopes Georgios Markozannes Fiona E. A. McGuigan Carolina Medina-Gomez Evangelia Ntzani Evangelia Ntzani Ling Oei Claes Ohlsson Claes Ohlsson Pawel Szulc Jonathan H. Tobias Jonathan H. Tobias Katerina Trajanoska Şansın Tuzun Amina Valjevac Bert van Rietbergen Graham R. Williams Tatjana Zekic Fernando Rivadeneira Barbara Obermayer-Pietsch |
| author_facet |
Ines Foessl J. H. Duncan Bassett Åshild Bjørnerem Åshild Bjørnerem Björn Busse Ângelo Calado Pascale Chavassieux Maria Christou Eleni Douni Eleni Douni Imke A. K. Fiedler João Eurico Fonseca João Eurico Fonseca Eva Hassler Wolfgang Högler Erika Kague David Karasik Patricia Khashayar Bente L. Langdahl Victoria D. Leitch Philippe Lopes Georgios Markozannes Fiona E. A. McGuigan Carolina Medina-Gomez Evangelia Ntzani Evangelia Ntzani Ling Oei Claes Ohlsson Claes Ohlsson Pawel Szulc Jonathan H. Tobias Jonathan H. Tobias Katerina Trajanoska Şansın Tuzun Amina Valjevac Bert van Rietbergen Graham R. Williams Tatjana Zekic Fernando Rivadeneira Barbara Obermayer-Pietsch |
| author_sort |
Ines Foessl |
| title |
Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”) |
| title_short |
Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”) |
| title_full |
Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”) |
| title_fullStr |
Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”) |
| title_full_unstemmed |
Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”) |
| title_sort |
bone phenotyping approaches in human, mice and zebrafish – expert overview of the eu cost action gemstone (“genomics of musculoskeletal traits translational network”) |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/f56aa12424184b2093ef7db929b89a6f |
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