The route to transcription initiation determines the mode of transcriptional bursting in E. coli

Transcription noise in bacteria is often attributed to burstiness, but the mechanisms are unclear. Here, the authors show that the transition from low to high expression can be regulated via burst size or burst frequency, depending on the mode of transcription initiation determined by different sigm...

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Autores principales:	Christoph Engl, Goran Jovanovic, Rowan D. Brackston, Ioly Kotta-Loizou, Martin Buck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f56bb2f173db41bf872c67ae336dcf01
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spelling	oai:doaj.org-article:f56bb2f173db41bf872c67ae336dcf012021-12-02T15:43:07ZThe route to transcription initiation determines the mode of transcriptional bursting in E. coli10.1038/s41467-020-16367-62041-1723https://doaj.org/article/f56bb2f173db41bf872c67ae336dcf012020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16367-6https://doaj.org/toc/2041-1723Transcription noise in bacteria is often attributed to burstiness, but the mechanisms are unclear. Here, the authors show that the transition from low to high expression can be regulated via burst size or burst frequency, depending on the mode of transcription initiation determined by different sigma factors.Christoph EnglGoran JovanovicRowan D. BrackstonIoly Kotta-LoizouMartin BuckNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christoph Engl Goran Jovanovic Rowan D. Brackston Ioly Kotta-Loizou Martin Buck The route to transcription initiation determines the mode of transcriptional bursting in E. coli
description	Transcription noise in bacteria is often attributed to burstiness, but the mechanisms are unclear. Here, the authors show that the transition from low to high expression can be regulated via burst size or burst frequency, depending on the mode of transcription initiation determined by different sigma factors.
format	article
author	Christoph Engl Goran Jovanovic Rowan D. Brackston Ioly Kotta-Loizou Martin Buck
author_facet	Christoph Engl Goran Jovanovic Rowan D. Brackston Ioly Kotta-Loizou Martin Buck
author_sort	Christoph Engl
title	The route to transcription initiation determines the mode of transcriptional bursting in E. coli
title_short	The route to transcription initiation determines the mode of transcriptional bursting in E. coli
title_full	The route to transcription initiation determines the mode of transcriptional bursting in E. coli
title_fullStr	The route to transcription initiation determines the mode of transcriptional bursting in E. coli
title_full_unstemmed	The route to transcription initiation determines the mode of transcriptional bursting in E. coli
title_sort	route to transcription initiation determines the mode of transcriptional bursting in e. coli
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f56bb2f173db41bf872c67ae336dcf01
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The route to transcription initiation determines the mode of transcriptional bursting in E. coli

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