Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer.

<h4>Objective</h4>The rare incidence of submucosal invasive non-ampullary duodenal carcinoma has led to scant information in literature; therefore, we compared the clinicopathological features between submucosal invasive carcinoma (SM-Ca), mucosal carcinoma (M-Ca), and advanced carcinoma...

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Autores principales:	Katsunori Matsueda, Hiromitsu Kanzaki, Ryuta Takenaka, Masahiro Nakagawa, Kazuhiro Matsueda, Masaya Iwamuro, Seiji Kawano, Yoshiro Kawahara, Tomohiro Toji, Takehiro Tanaka, Takahito Yagi, Toshiyoshi Fujiwara, Hiroyuki Okada
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f56dc1d9a0b44cb88ca59770a5b0a6ff
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spelling	oai:doaj.org-article:f56dc1d9a0b44cb88ca59770a5b0a6ff2021-12-02T20:19:24ZClinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer.1932-620310.1371/journal.pone.0256797https://doaj.org/article/f56dc1d9a0b44cb88ca59770a5b0a6ff2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256797https://doaj.org/toc/1932-6203<h4>Objective</h4>The rare incidence of submucosal invasive non-ampullary duodenal carcinoma has led to scant information in literature; therefore, we compared the clinicopathological features between submucosal invasive carcinoma (SM-Ca), mucosal carcinoma (M-Ca), and advanced carcinoma (Ad-Ca).<h4>Materials</h4>We retrospectively analyzed 165 patients with sporadic non-ampullary duodenal carcinomas (SNADCs) from four institutions between January 2003 and December 2018. The SNADCs were divided to three groups according to histological diagnosis: SM-Ca, M-Ca, and Ad-Ca. The clinicopathological characteristics and mucin phenotypes were compared between groups.<h4>Results</h4>Among the 165 SNADCs, 11 (7%) were classified as SM-Ca, 70 (42%) as M-Ca, and 84 (51%) as Ad-Ca. We found that all SM-Ca (P = 0.013) and most Ad-Ca (P = 0.020) lesions were located on the oral-Vater; however, an almost equal distribution of M-Ca lesions was found between the oral- and anal-Vater. No significant difference was observed between the tumor diameter of M-Ca and SM-Ca; however, 45% (5/11) of SM-Ca were ≤10 mm. A total of 73% (8/11) of SM-Ca were classified as gastric phenotype and no lesions were classified as intestinal phenotype; whereas most M-Ca were classified as intestinal phenotype (67%, 8/12).<h4>Conclusions</h4>SM-Ca lesions were all located on the oral-Vater and were highly associated with the gastric mucin phenotype, which were different from the features of most M-Ca.Katsunori MatsuedaHiromitsu KanzakiRyuta TakenakaMasahiro NakagawaKazuhiro MatsuedaMasaya IwamuroSeiji KawanoYoshiro KawaharaTomohiro TojiTakehiro TanakaTakahito YagiToshiyoshi FujiwaraHiroyuki OkadaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256797 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katsunori Matsueda Hiromitsu Kanzaki Ryuta Takenaka Masahiro Nakagawa Kazuhiro Matsueda Masaya Iwamuro Seiji Kawano Yoshiro Kawahara Tomohiro Toji Takehiro Tanaka Takahito Yagi Toshiyoshi Fujiwara Hiroyuki Okada Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer.
description	<h4>Objective</h4>The rare incidence of submucosal invasive non-ampullary duodenal carcinoma has led to scant information in literature; therefore, we compared the clinicopathological features between submucosal invasive carcinoma (SM-Ca), mucosal carcinoma (M-Ca), and advanced carcinoma (Ad-Ca).<h4>Materials</h4>We retrospectively analyzed 165 patients with sporadic non-ampullary duodenal carcinomas (SNADCs) from four institutions between January 2003 and December 2018. The SNADCs were divided to three groups according to histological diagnosis: SM-Ca, M-Ca, and Ad-Ca. The clinicopathological characteristics and mucin phenotypes were compared between groups.<h4>Results</h4>Among the 165 SNADCs, 11 (7%) were classified as SM-Ca, 70 (42%) as M-Ca, and 84 (51%) as Ad-Ca. We found that all SM-Ca (P = 0.013) and most Ad-Ca (P = 0.020) lesions were located on the oral-Vater; however, an almost equal distribution of M-Ca lesions was found between the oral- and anal-Vater. No significant difference was observed between the tumor diameter of M-Ca and SM-Ca; however, 45% (5/11) of SM-Ca were ≤10 mm. A total of 73% (8/11) of SM-Ca were classified as gastric phenotype and no lesions were classified as intestinal phenotype; whereas most M-Ca were classified as intestinal phenotype (67%, 8/12).<h4>Conclusions</h4>SM-Ca lesions were all located on the oral-Vater and were highly associated with the gastric mucin phenotype, which were different from the features of most M-Ca.
format	article
author	Katsunori Matsueda Hiromitsu Kanzaki Ryuta Takenaka Masahiro Nakagawa Kazuhiro Matsueda Masaya Iwamuro Seiji Kawano Yoshiro Kawahara Tomohiro Toji Takehiro Tanaka Takahito Yagi Toshiyoshi Fujiwara Hiroyuki Okada
author_facet	Katsunori Matsueda Hiromitsu Kanzaki Ryuta Takenaka Masahiro Nakagawa Kazuhiro Matsueda Masaya Iwamuro Seiji Kawano Yoshiro Kawahara Tomohiro Toji Takehiro Tanaka Takahito Yagi Toshiyoshi Fujiwara Hiroyuki Okada
author_sort	Katsunori Matsueda
title	Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer.
title_short	Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer.
title_full	Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer.
title_fullStr	Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer.
title_full_unstemmed	Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer.
title_sort	clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/f56dc1d9a0b44cb88ca59770a5b0a6ff
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Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer.

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