Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide

Bullo Saifullah,1 Palanisamy Arulselvan,2 Mohamed Ezzat El Zowalaty,2,3 Sharida Fakurazi,2,4 Thomas J Webster,5,6 Benjamin M Geilich,5 Mohd Zobir Hussein1 1Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, 2Laboratory of Vaccines and Immunotherapeutics, Institu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Saifullah B, Arulselvan P, El Zowalaty ME, Fakurazi S, Webster TJ, Geilich BM, Hussein MZ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f56e13d25547436181d94580f0a0e1b8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f56e13d25547436181d94580f0a0e1b8
record_format	dspace
spelling	oai:doaj.org-article:f56e13d25547436181d94580f0a0e1b82021-12-02T01:07:57ZDevelopment of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide1178-2013https://doaj.org/article/f56e13d25547436181d94580f0a0e1b82014-10-01T00:00:00Zhttp://www.dovepress.com/development-of-a-biocompatible-nanodelivery-system-for-tuberculosis-dr-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Bullo Saifullah,1 Palanisamy Arulselvan,2 Mohamed Ezzat El Zowalaty,2,3 Sharida Fakurazi,2,4 Thomas J Webster,5,6 Benjamin M Geilich,5 Mohd Zobir Hussein1 1Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, 2Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 3Department of Environmental Health, Faculty of Public Health and Tropical Medicine, Jazan University, Jazan, Saudi Arabia; 4Department of Human Anatomy, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 5Department of Chemical Engineering and Program in Bioengineering, Northeastern University, Boston, MA, USA; 6Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia Abstract: The primary challenge in finding a treatment for tuberculosis (TB) is patient non-compliance to treatment due to long treatment duration, high dosing frequency, and adverse effects of anti-TB drugs. This study reports on the development of a nanodelivery system that intercalates the anti-TB drug isoniazid into Mg/Al layered double hydroxides (LDHs). Isoniazid was found to be released in a sustained manner from the novel nanodelivery system in humans in simulated phosphate buffer solutions at pH 4.8 and pH 7.4. The nanodelivery formulation was highly biocompatible compared to free isoniazid against human normal lung and 3T3 mouse fibroblast cells. The formulation was active against Mycobacterium tuberculosis and gram-positive bacteria and gram-negative bacteria. Thus results show significant promise for the further study of these nanocomposites for the treatment of TB. Keywords: tuberculosis, isoniazid, Mg/Al LDH, nanodelivery systemSaifullah BArulselvan PEl Zowalaty MEFakurazi SWebster TJGeilich BMHussein MZDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 4749-4762 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Saifullah B Arulselvan P El Zowalaty ME Fakurazi S Webster TJ Geilich BM Hussein MZ Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide
description	Bullo Saifullah,1 Palanisamy Arulselvan,2 Mohamed Ezzat El Zowalaty,2,3 Sharida Fakurazi,2,4 Thomas J Webster,5,6 Benjamin M Geilich,5 Mohd Zobir Hussein1 1Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, 2Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 3Department of Environmental Health, Faculty of Public Health and Tropical Medicine, Jazan University, Jazan, Saudi Arabia; 4Department of Human Anatomy, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 5Department of Chemical Engineering and Program in Bioengineering, Northeastern University, Boston, MA, USA; 6Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia Abstract: The primary challenge in finding a treatment for tuberculosis (TB) is patient non-compliance to treatment due to long treatment duration, high dosing frequency, and adverse effects of anti-TB drugs. This study reports on the development of a nanodelivery system that intercalates the anti-TB drug isoniazid into Mg/Al layered double hydroxides (LDHs). Isoniazid was found to be released in a sustained manner from the novel nanodelivery system in humans in simulated phosphate buffer solutions at pH 4.8 and pH 7.4. The nanodelivery formulation was highly biocompatible compared to free isoniazid against human normal lung and 3T3 mouse fibroblast cells. The formulation was active against Mycobacterium tuberculosis and gram-positive bacteria and gram-negative bacteria. Thus results show significant promise for the further study of these nanocomposites for the treatment of TB. Keywords: tuberculosis, isoniazid, Mg/Al LDH, nanodelivery system
format	article
author	Saifullah B Arulselvan P El Zowalaty ME Fakurazi S Webster TJ Geilich BM Hussein MZ
author_facet	Saifullah B Arulselvan P El Zowalaty ME Fakurazi S Webster TJ Geilich BM Hussein MZ
author_sort	Saifullah B
title	Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide
title_short	Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide
title_full	Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide
title_fullStr	Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide
title_full_unstemmed	Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide
title_sort	development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-mg/al layered double hydroxide
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/f56e13d25547436181d94580f0a0e1b8
work_keys_str_mv	AT saifullahb developmentofabiocompatiblenanodeliverysystemfortuberculosisdrugsbasedonisoniazidmgallayereddoublehydroxide AT arulselvanp developmentofabiocompatiblenanodeliverysystemfortuberculosisdrugsbasedonisoniazidmgallayereddoublehydroxide AT elzowalatyme developmentofabiocompatiblenanodeliverysystemfortuberculosisdrugsbasedonisoniazidmgallayereddoublehydroxide AT fakurazis developmentofabiocompatiblenanodeliverysystemfortuberculosisdrugsbasedonisoniazidmgallayereddoublehydroxide AT webstertj developmentofabiocompatiblenanodeliverysystemfortuberculosisdrugsbasedonisoniazidmgallayereddoublehydroxide AT geilichbm developmentofabiocompatiblenanodeliverysystemfortuberculosisdrugsbasedonisoniazidmgallayereddoublehydroxide AT husseinmz developmentofabiocompatiblenanodeliverysystemfortuberculosisdrugsbasedonisoniazidmgallayereddoublehydroxide
_version_	1718403292829057024

Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide

Ejemplares similares