The Dual Role of Circular RNAs as miRNA Sponges in Breast Cancer and Colon Cancer

Breast cancer (BC) and colon cancer (CRC) are the two most deadly cancers in the world. These cancers partly share the same genetic background and are partially regulated by the same genes. The outcomes of traditional chemoradiotherapy and surgery remain suboptimal, with high postoperative recurrenc...

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Autores principales:	Jiashu Huang, Shenghao Yu, Lei Ding, Lingyuan Ma, Hongjian Chen, Hui Zhou, Yayan Zou, Min Yu, Jie Lin, Qinghua Cui
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	circRNA miRNA sponge breast cancer colorectal cancer Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f56f5ef8b3d64b689687b3cc81ec6160
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spelling	oai:doaj.org-article:f56f5ef8b3d64b689687b3cc81ec61602021-11-25T16:49:23ZThe Dual Role of Circular RNAs as miRNA Sponges in Breast Cancer and Colon Cancer10.3390/biomedicines91115902227-9059https://doaj.org/article/f56f5ef8b3d64b689687b3cc81ec61602021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1590https://doaj.org/toc/2227-9059Breast cancer (BC) and colon cancer (CRC) are the two most deadly cancers in the world. These cancers partly share the same genetic background and are partially regulated by the same genes. The outcomes of traditional chemoradiotherapy and surgery remain suboptimal, with high postoperative recurrence and a low survival rate. It is, therefore, urgent to innovate and improve the existing treatment measures. Many studies primarily reported that the microRNA (miRNA) sponge functions of circular RNA (circRNA) in BC and CRC have an indirect relationship between the circRNA–miRNA axis and malignant behaviors. With a covalent ring structure, circRNAs can regulate the expression of target genes in multiple ways, especially by acting as miRNA sponges. Therefore, this review mainly focuses on the roles of circRNAs as miRNA sponges in BC and CRC based on studies over the last three years, thus providing a theoretical reference for finding new therapeutic targets in the future.Jiashu HuangShenghao YuLei DingLingyuan MaHongjian ChenHui ZhouYayan ZouMin YuJie LinQinghua CuiMDPI AGarticlecircRNAmiRNA spongebreast cancercolorectal cancerBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1590, p 1590 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circRNA miRNA sponge breast cancer colorectal cancer Biology (General) QH301-705.5
spellingShingle	circRNA miRNA sponge breast cancer colorectal cancer Biology (General) QH301-705.5 Jiashu Huang Shenghao Yu Lei Ding Lingyuan Ma Hongjian Chen Hui Zhou Yayan Zou Min Yu Jie Lin Qinghua Cui The Dual Role of Circular RNAs as miRNA Sponges in Breast Cancer and Colon Cancer
description	Breast cancer (BC) and colon cancer (CRC) are the two most deadly cancers in the world. These cancers partly share the same genetic background and are partially regulated by the same genes. The outcomes of traditional chemoradiotherapy and surgery remain suboptimal, with high postoperative recurrence and a low survival rate. It is, therefore, urgent to innovate and improve the existing treatment measures. Many studies primarily reported that the microRNA (miRNA) sponge functions of circular RNA (circRNA) in BC and CRC have an indirect relationship between the circRNA–miRNA axis and malignant behaviors. With a covalent ring structure, circRNAs can regulate the expression of target genes in multiple ways, especially by acting as miRNA sponges. Therefore, this review mainly focuses on the roles of circRNAs as miRNA sponges in BC and CRC based on studies over the last three years, thus providing a theoretical reference for finding new therapeutic targets in the future.
format	article
author	Jiashu Huang Shenghao Yu Lei Ding Lingyuan Ma Hongjian Chen Hui Zhou Yayan Zou Min Yu Jie Lin Qinghua Cui
author_facet	Jiashu Huang Shenghao Yu Lei Ding Lingyuan Ma Hongjian Chen Hui Zhou Yayan Zou Min Yu Jie Lin Qinghua Cui
author_sort	Jiashu Huang
title	The Dual Role of Circular RNAs as miRNA Sponges in Breast Cancer and Colon Cancer
title_short	The Dual Role of Circular RNAs as miRNA Sponges in Breast Cancer and Colon Cancer
title_full	The Dual Role of Circular RNAs as miRNA Sponges in Breast Cancer and Colon Cancer
title_fullStr	The Dual Role of Circular RNAs as miRNA Sponges in Breast Cancer and Colon Cancer
title_full_unstemmed	The Dual Role of Circular RNAs as miRNA Sponges in Breast Cancer and Colon Cancer
title_sort	dual role of circular rnas as mirna sponges in breast cancer and colon cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f56f5ef8b3d64b689687b3cc81ec6160
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The Dual Role of Circular RNAs as miRNA Sponges in Breast Cancer and Colon Cancer

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