Topological clustering of regulatory genes confers pathogenic tolerance to cassava brown streak virus (CBSV) in cassava

Abstract Robustness, a naïve property of biological systems, enables organisms to maintain functions during perturbation and is crucial for improving the resilience of crops to prevailing stress conditions and diseases, guaranteeing food security. Most studies of robustness in crops have focused on...

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Autores principales:	Thanakorn Jaemthaworn, Saowalak Kalapanulak, Treenut Saithong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f5708b52dc7e43d78bba792065e6cc38
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spelling	oai:doaj.org-article:f5708b52dc7e43d78bba792065e6cc382021-12-02T14:26:12ZTopological clustering of regulatory genes confers pathogenic tolerance to cassava brown streak virus (CBSV) in cassava10.1038/s41598-021-86806-x2045-2322https://doaj.org/article/f5708b52dc7e43d78bba792065e6cc382021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86806-xhttps://doaj.org/toc/2045-2322Abstract Robustness, a naïve property of biological systems, enables organisms to maintain functions during perturbation and is crucial for improving the resilience of crops to prevailing stress conditions and diseases, guaranteeing food security. Most studies of robustness in crops have focused on genetic superiority based upon individual genes, overlooking the collaborative actions of multiple responsive genes and the regulatory network topology. This research aims to uncover patterns of gene cooperation leading to organismal robustness by studying the topology of gene co-expression networks (GCNs) of both CBSV virus resistant and susceptible cassava cultivars. The resulting GCNs show higher topological clustering of cooperative genes in the resistant cultivar, suggesting that the network architecture is central to attaining robustness. Despite a reduction in the number of hub genes in the resistant cultivar following the perturbation, essential biological functions contained in the network were maintained through neighboring genes that withstood the shock. The susceptible cultivar seemingly coped by inducing more gene actions in the network but could not maintain the functions required for plant growth. These findings underscore the importance of regulatory network architecture in ensuring phenotypic robustness and deepen our understanding of transcriptional regulation.Thanakorn JaemthawornSaowalak KalapanulakTreenut SaithongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Thanakorn Jaemthaworn Saowalak Kalapanulak Treenut Saithong Topological clustering of regulatory genes confers pathogenic tolerance to cassava brown streak virus (CBSV) in cassava
description	Abstract Robustness, a naïve property of biological systems, enables organisms to maintain functions during perturbation and is crucial for improving the resilience of crops to prevailing stress conditions and diseases, guaranteeing food security. Most studies of robustness in crops have focused on genetic superiority based upon individual genes, overlooking the collaborative actions of multiple responsive genes and the regulatory network topology. This research aims to uncover patterns of gene cooperation leading to organismal robustness by studying the topology of gene co-expression networks (GCNs) of both CBSV virus resistant and susceptible cassava cultivars. The resulting GCNs show higher topological clustering of cooperative genes in the resistant cultivar, suggesting that the network architecture is central to attaining robustness. Despite a reduction in the number of hub genes in the resistant cultivar following the perturbation, essential biological functions contained in the network were maintained through neighboring genes that withstood the shock. The susceptible cultivar seemingly coped by inducing more gene actions in the network but could not maintain the functions required for plant growth. These findings underscore the importance of regulatory network architecture in ensuring phenotypic robustness and deepen our understanding of transcriptional regulation.
format	article
author	Thanakorn Jaemthaworn Saowalak Kalapanulak Treenut Saithong
author_facet	Thanakorn Jaemthaworn Saowalak Kalapanulak Treenut Saithong
author_sort	Thanakorn Jaemthaworn
title	Topological clustering of regulatory genes confers pathogenic tolerance to cassava brown streak virus (CBSV) in cassava
title_short	Topological clustering of regulatory genes confers pathogenic tolerance to cassava brown streak virus (CBSV) in cassava
title_full	Topological clustering of regulatory genes confers pathogenic tolerance to cassava brown streak virus (CBSV) in cassava
title_fullStr	Topological clustering of regulatory genes confers pathogenic tolerance to cassava brown streak virus (CBSV) in cassava
title_full_unstemmed	Topological clustering of regulatory genes confers pathogenic tolerance to cassava brown streak virus (CBSV) in cassava
title_sort	topological clustering of regulatory genes confers pathogenic tolerance to cassava brown streak virus (cbsv) in cassava
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f5708b52dc7e43d78bba792065e6cc38
work_keys_str_mv	AT thanakornjaemthaworn topologicalclusteringofregulatorygenesconferspathogenictolerancetocassavabrownstreakviruscbsvincassava AT saowalakkalapanulak topologicalclusteringofregulatorygenesconferspathogenictolerancetocassavabrownstreakviruscbsvincassava AT treenutsaithong topologicalclusteringofregulatorygenesconferspathogenictolerancetocassavabrownstreakviruscbsvincassava
_version_	1718391404782157824

Topological clustering of regulatory genes confers pathogenic tolerance to cassava brown streak virus (CBSV) in cassava

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