Optimal blood pressure for patients with chronic kidney disease: a nationwide population-based cohort study

Abstract The effect of blood pressure (BP) on the incident cardiovascular events, progression to end-stage renal disease (ESRD) and mortality were evaluated among chronic kidney disease (CKD) patients with and without antihypertensive treatment. This nationwide study used the Korean National Health...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	You-Bin Lee, Ji Sung Lee, So-hyeon Hong, Jung A. Kim, Eun Roh, Hye Jin Yoo, Sei Hyun Baik, Kyung Mook Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f5711952a1c54440aa84da1849a19023
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f5711952a1c54440aa84da1849a19023
record_format	dspace
spelling	oai:doaj.org-article:f5711952a1c54440aa84da1849a190232021-12-02T15:22:57ZOptimal blood pressure for patients with chronic kidney disease: a nationwide population-based cohort study10.1038/s41598-021-81328-y2045-2322https://doaj.org/article/f5711952a1c54440aa84da1849a190232021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81328-yhttps://doaj.org/toc/2045-2322Abstract The effect of blood pressure (BP) on the incident cardiovascular events, progression to end-stage renal disease (ESRD) and mortality were evaluated among chronic kidney disease (CKD) patients with and without antihypertensive treatment. This nationwide study used the Korean National Health Insurance Service-Health Screening Cohort data. The hazards of outcomes were analysed according to the systolic BP (SBP) or diastolic BP (DBP) among adults (aged ≥ 40 years) with CKD and without previous cardiovascular disease or ESRD (n = 22,278). The SBP and DBP were ≥ 130 mmHg and ≥ 80 mmHg in 10,809 (48.52%) and 11,583 (51.99%) participants, respectively. During a median 6.2 years, 1271 cardiovascular events, 201 ESRD incidents, and 1061 deaths were noted. Individuals with SBP ≥ 130 mmHg and DBP ≥ 80 mmHg had higher hazards of hypertension-related adverse outcomes compared to the references (SBP 120–129 mmHg and DBP 70–79 mmHg). SBP < 100 mmHg was associated with hazards of all-cause death, and composite of ESRD and all-cause death during follow-up only among the antihypertensive medication users suggesting that the BP should be < 130/80 mmHg and the SBP should not be < 100 mmHg with antihypertensive agents to prevent the adverse outcome risk of insufficient and excessive antihypertensive treatment in CKD patients.You-Bin LeeJi Sung LeeSo-hyeon HongJung A. KimEun RohHye Jin YooSei Hyun BaikKyung Mook ChoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q You-Bin Lee Ji Sung Lee So-hyeon Hong Jung A. Kim Eun Roh Hye Jin Yoo Sei Hyun Baik Kyung Mook Choi Optimal blood pressure for patients with chronic kidney disease: a nationwide population-based cohort study
description	Abstract The effect of blood pressure (BP) on the incident cardiovascular events, progression to end-stage renal disease (ESRD) and mortality were evaluated among chronic kidney disease (CKD) patients with and without antihypertensive treatment. This nationwide study used the Korean National Health Insurance Service-Health Screening Cohort data. The hazards of outcomes were analysed according to the systolic BP (SBP) or diastolic BP (DBP) among adults (aged ≥ 40 years) with CKD and without previous cardiovascular disease or ESRD (n = 22,278). The SBP and DBP were ≥ 130 mmHg and ≥ 80 mmHg in 10,809 (48.52%) and 11,583 (51.99%) participants, respectively. During a median 6.2 years, 1271 cardiovascular events, 201 ESRD incidents, and 1061 deaths were noted. Individuals with SBP ≥ 130 mmHg and DBP ≥ 80 mmHg had higher hazards of hypertension-related adverse outcomes compared to the references (SBP 120–129 mmHg and DBP 70–79 mmHg). SBP < 100 mmHg was associated with hazards of all-cause death, and composite of ESRD and all-cause death during follow-up only among the antihypertensive medication users suggesting that the BP should be < 130/80 mmHg and the SBP should not be < 100 mmHg with antihypertensive agents to prevent the adverse outcome risk of insufficient and excessive antihypertensive treatment in CKD patients.
format	article
author	You-Bin Lee Ji Sung Lee So-hyeon Hong Jung A. Kim Eun Roh Hye Jin Yoo Sei Hyun Baik Kyung Mook Choi
author_facet	You-Bin Lee Ji Sung Lee So-hyeon Hong Jung A. Kim Eun Roh Hye Jin Yoo Sei Hyun Baik Kyung Mook Choi
author_sort	You-Bin Lee
title	Optimal blood pressure for patients with chronic kidney disease: a nationwide population-based cohort study
title_short	Optimal blood pressure for patients with chronic kidney disease: a nationwide population-based cohort study
title_full	Optimal blood pressure for patients with chronic kidney disease: a nationwide population-based cohort study
title_fullStr	Optimal blood pressure for patients with chronic kidney disease: a nationwide population-based cohort study
title_full_unstemmed	Optimal blood pressure for patients with chronic kidney disease: a nationwide population-based cohort study
title_sort	optimal blood pressure for patients with chronic kidney disease: a nationwide population-based cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f5711952a1c54440aa84da1849a19023
work_keys_str_mv	AT youbinlee optimalbloodpressureforpatientswithchronickidneydiseaseanationwidepopulationbasedcohortstudy AT jisunglee optimalbloodpressureforpatientswithchronickidneydiseaseanationwidepopulationbasedcohortstudy AT sohyeonhong optimalbloodpressureforpatientswithchronickidneydiseaseanationwidepopulationbasedcohortstudy AT jungakim optimalbloodpressureforpatientswithchronickidneydiseaseanationwidepopulationbasedcohortstudy AT eunroh optimalbloodpressureforpatientswithchronickidneydiseaseanationwidepopulationbasedcohortstudy AT hyejinyoo optimalbloodpressureforpatientswithchronickidneydiseaseanationwidepopulationbasedcohortstudy AT seihyunbaik optimalbloodpressureforpatientswithchronickidneydiseaseanationwidepopulationbasedcohortstudy AT kyungmookchoi optimalbloodpressureforpatientswithchronickidneydiseaseanationwidepopulationbasedcohortstudy
_version_	1718387406576549888

Optimal blood pressure for patients with chronic kidney disease: a nationwide population-based cohort study

Ejemplares similares