Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis

The adaptor protein SHN3 suppresses new bone formation by controlling osteoblast activity. Here, the authors show that ablation of SHN3 function, either genetically or by delivering an artificial miRNA via AAV9, rescues bone loss in osteoporotic mice, and show that engineering of the AAV9 capsid imp...

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Autores principales:	Yeon-Suk Yang, Jun Xie, Dan Wang, Jung-Min Kim, Phillip W. L. Tai, Ellen Gravallese, Guangping Gao, Jae-Hyuck Shim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f5712a6562894f83a8d6b6c45bb24c53
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id	oai:doaj.org-article:f5712a6562894f83a8d6b6c45bb24c53
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spelling	oai:doaj.org-article:f5712a6562894f83a8d6b6c45bb24c532021-12-02T16:57:36ZBone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis10.1038/s41467-019-10809-62041-1723https://doaj.org/article/f5712a6562894f83a8d6b6c45bb24c532019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10809-6https://doaj.org/toc/2041-1723The adaptor protein SHN3 suppresses new bone formation by controlling osteoblast activity. Here, the authors show that ablation of SHN3 function, either genetically or by delivering an artificial miRNA via AAV9, rescues bone loss in osteoporotic mice, and show that engineering of the AAV9 capsid improves targeting to boneYeon-Suk YangJun XieDan WangJung-Min KimPhillip W. L. TaiEllen GravalleseGuangping GaoJae-Hyuck ShimNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yeon-Suk Yang Jun Xie Dan Wang Jung-Min Kim Phillip W. L. Tai Ellen Gravallese Guangping Gao Jae-Hyuck Shim Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis
description	The adaptor protein SHN3 suppresses new bone formation by controlling osteoblast activity. Here, the authors show that ablation of SHN3 function, either genetically or by delivering an artificial miRNA via AAV9, rescues bone loss in osteoporotic mice, and show that engineering of the AAV9 capsid improves targeting to bone
format	article
author	Yeon-Suk Yang Jun Xie Dan Wang Jung-Min Kim Phillip W. L. Tai Ellen Gravallese Guangping Gao Jae-Hyuck Shim
author_facet	Yeon-Suk Yang Jun Xie Dan Wang Jung-Min Kim Phillip W. L. Tai Ellen Gravallese Guangping Gao Jae-Hyuck Shim
author_sort	Yeon-Suk Yang
title	Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis
title_short	Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis
title_full	Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis
title_fullStr	Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis
title_full_unstemmed	Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis
title_sort	bone-targeting aav-mediated silencing of schnurri-3 prevents bone loss in osteoporosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f5712a6562894f83a8d6b6c45bb24c53
work_keys_str_mv	AT yeonsukyang bonetargetingaavmediatedsilencingofschnurri3preventsbonelossinosteoporosis AT junxie bonetargetingaavmediatedsilencingofschnurri3preventsbonelossinosteoporosis AT danwang bonetargetingaavmediatedsilencingofschnurri3preventsbonelossinosteoporosis AT jungminkim bonetargetingaavmediatedsilencingofschnurri3preventsbonelossinosteoporosis AT phillipwltai bonetargetingaavmediatedsilencingofschnurri3preventsbonelossinosteoporosis AT ellengravallese bonetargetingaavmediatedsilencingofschnurri3preventsbonelossinosteoporosis AT guangpinggao bonetargetingaavmediatedsilencingofschnurri3preventsbonelossinosteoporosis AT jaehyuckshim bonetargetingaavmediatedsilencingofschnurri3preventsbonelossinosteoporosis
_version_	1718382540676399104

Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis

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