Longstanding postoperative fluid collection influences recurrence of pancreatic malignancy

Background/Aims Postoperative abdominal fluid collection (PAFC) is a frequent complication of pancreatobiliary cancer surgery. The effects of the existence and duration of PAFC are not well known. This study aimed to assess the effects of PAFC on patient prognosis after surgery for pancreatobiliary...

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Autores principales:	Young Jung Kim, Young Koog Cheon, Tae Yoon Lee, Seong-Hwan Chang, Mi-Hye Yu
Formato:	article
Lenguaje:	EN
Publicado:	The Korean Association of Internal Medicine 2021
Materias:	pancreatic neoplasms biliary tract neoplasms recurrence survival ascitic fluid Medicine R
Acceso en línea:	https://doaj.org/article/f57271c224df4f56843b715264755db0
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spelling	oai:doaj.org-article:f57271c224df4f56843b715264755db02021-11-08T00:59:06ZLongstanding postoperative fluid collection influences recurrence of pancreatic malignancy1226-33032005-664810.3904/kjim.2021.056https://doaj.org/article/f57271c224df4f56843b715264755db02021-11-01T00:00:00Zhttp://www.kjim.org/upload/pdf/kjim-2021-056.pdfhttps://doaj.org/toc/1226-3303https://doaj.org/toc/2005-6648Background/Aims Postoperative abdominal fluid collection (PAFC) is a frequent complication of pancreatobiliary cancer surgery. The effects of the existence and duration of PAFC are not well known. This study aimed to assess the effects of PAFC on patient prognosis after surgery for pancreatobiliary adenocarcinoma and the association of longstanding PAFC with the recurrence of pancreatic cancer. Methods We retrospectively analyzed the data of 194 consecutive patients with pancreatobiliary adenocarcinoma who underwent curative operations from August 2005 to December 2019. The presence of PAFC was assessed using computed tomography within a week of surgery; PAFC lasting > 4 weeks was defined as longstanding PAFC. Results Among 194 patients, PAFC occurred in 165 (85.1%), and 74 of these had longstanding PAFC. The recurrence rate of pancreatobiliary adenocarcinoma was significantly higher in patients with longstanding PAFC than in patients with non-longstanding PAFC (p = 0.025). Recurrence was also significantly associated with high T stage (T3, T4; p = 0.040), lymph node involvement (p < 0.001), perineural invasion (p < 0.006), and non-receipt of adjuvant chemotherapy (p = 0.025). Longstanding PAFC was significantly associated with the recurrence of pancreatic adenocarcinoma (p = 0.016). However, cancer-specific survival was related to neither the presence nor the duration of PAFC. Conclusions The presence of longstanding PAFC was associated with the recurrence of pancreatic adenocarcinoma. However, a larger prospective study is necessary to confirm the findings.Young Jung KimYoung Koog CheonTae Yoon LeeSeong-Hwan ChangMi-Hye YuThe Korean Association of Internal Medicinearticlepancreatic neoplasmsbiliary tract neoplasmsrecurrencesurvivalascitic fluidMedicineRENThe Korean Journal of Internal Medicine, Vol 36, Iss 6, Pp 1338-1346 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pancreatic neoplasms biliary tract neoplasms recurrence survival ascitic fluid Medicine R
spellingShingle	pancreatic neoplasms biliary tract neoplasms recurrence survival ascitic fluid Medicine R Young Jung Kim Young Koog Cheon Tae Yoon Lee Seong-Hwan Chang Mi-Hye Yu Longstanding postoperative fluid collection influences recurrence of pancreatic malignancy
description	Background/Aims Postoperative abdominal fluid collection (PAFC) is a frequent complication of pancreatobiliary cancer surgery. The effects of the existence and duration of PAFC are not well known. This study aimed to assess the effects of PAFC on patient prognosis after surgery for pancreatobiliary adenocarcinoma and the association of longstanding PAFC with the recurrence of pancreatic cancer. Methods We retrospectively analyzed the data of 194 consecutive patients with pancreatobiliary adenocarcinoma who underwent curative operations from August 2005 to December 2019. The presence of PAFC was assessed using computed tomography within a week of surgery; PAFC lasting > 4 weeks was defined as longstanding PAFC. Results Among 194 patients, PAFC occurred in 165 (85.1%), and 74 of these had longstanding PAFC. The recurrence rate of pancreatobiliary adenocarcinoma was significantly higher in patients with longstanding PAFC than in patients with non-longstanding PAFC (p = 0.025). Recurrence was also significantly associated with high T stage (T3, T4; p = 0.040), lymph node involvement (p < 0.001), perineural invasion (p < 0.006), and non-receipt of adjuvant chemotherapy (p = 0.025). Longstanding PAFC was significantly associated with the recurrence of pancreatic adenocarcinoma (p = 0.016). However, cancer-specific survival was related to neither the presence nor the duration of PAFC. Conclusions The presence of longstanding PAFC was associated with the recurrence of pancreatic adenocarcinoma. However, a larger prospective study is necessary to confirm the findings.
format	article
author	Young Jung Kim Young Koog Cheon Tae Yoon Lee Seong-Hwan Chang Mi-Hye Yu
author_facet	Young Jung Kim Young Koog Cheon Tae Yoon Lee Seong-Hwan Chang Mi-Hye Yu
author_sort	Young Jung Kim
title	Longstanding postoperative fluid collection influences recurrence of pancreatic malignancy
title_short	Longstanding postoperative fluid collection influences recurrence of pancreatic malignancy
title_full	Longstanding postoperative fluid collection influences recurrence of pancreatic malignancy
title_fullStr	Longstanding postoperative fluid collection influences recurrence of pancreatic malignancy
title_full_unstemmed	Longstanding postoperative fluid collection influences recurrence of pancreatic malignancy
title_sort	longstanding postoperative fluid collection influences recurrence of pancreatic malignancy
publisher	The Korean Association of Internal Medicine
publishDate	2021
url	https://doaj.org/article/f57271c224df4f56843b715264755db0
work_keys_str_mv	AT youngjungkim longstandingpostoperativefluidcollectioninfluencesrecurrenceofpancreaticmalignancy AT youngkoogcheon longstandingpostoperativefluidcollectioninfluencesrecurrenceofpancreaticmalignancy AT taeyoonlee longstandingpostoperativefluidcollectioninfluencesrecurrenceofpancreaticmalignancy AT seonghwanchang longstandingpostoperativefluidcollectioninfluencesrecurrenceofpancreaticmalignancy AT mihyeyu longstandingpostoperativefluidcollectioninfluencesrecurrenceofpancreaticmalignancy
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Longstanding postoperative fluid collection influences recurrence of pancreatic malignancy

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