Association between the PLTP rs4810479 SNP and Serum Lipid Traits in the Chinese Maonan and Han Populations

The association between the phospholipid transfer protein (PLTP) gene rs4810479 single-nucleotide polymorphism (SNP) and serum lipid levels is largely unknown. This investigation aimed to evaluate the relationship between the PLTP rs4810479 SNP, several environmental risk factors, and serum lipid pa...

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Autores principales:	Fen-Han Zhang, Rui-Xing Yin, Li-Mei Yao, Wei-Xiong Lin, Jin-Zhen Wu, De-Zhai Yang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi - Cambridge University Press 2021
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/f5750c39d63d4a31beec4f469e333b47
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spelling	oai:doaj.org-article:f5750c39d63d4a31beec4f469e333b472021-12-02T19:24:16ZAssociation between the PLTP rs4810479 SNP and Serum Lipid Traits in the Chinese Maonan and Han Populations0016-67231469-507310.1155/2021/9925272https://doaj.org/article/f5750c39d63d4a31beec4f469e333b472021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/9925272https://doaj.org/toc/0016-6723https://doaj.org/toc/1469-5073The association between the phospholipid transfer protein (PLTP) gene rs4810479 single-nucleotide polymorphism (SNP) and serum lipid levels is largely unknown. This investigation aimed to evaluate the relationship between the PLTP rs4810479 SNP, several environmental risk factors, and serum lipid parameters in the Chinese Maonan and Han nationalities. Polymerase chain reaction-restriction fragment length polymorphism, gel electrophoresis, and direct sequencing were employed to determine the PLTP rs4810479 genotypes in 633 Maonan and 646 Han participants. The frequencies of CC, CT, and TT genotypes and the C allele were different between Maonan and Han groups (29.07%, 53.08%, 17.85%, and 55.61% vs. 35.60%, 49.70%, 14.70%, and 60.45%, respectively, P<0.05). The C allele carriers in the Maonan group had higher high-density lipoprotein cholesterol levels than the C allele noncarriers, but this finding was only found in Maonan males but not in females. The C allele carriers in Han males had lower total cholesterol and low-density lipoprotein cholesterol levels than the C allele noncarriers. Serum lipid profiles were also affected by several traditional cardiovascular risk factors in both populations. There might be an ethnic- and/or sex-specific association between the PLTP rs4810479 SNP and serum lipid traits.Fen-Han ZhangRui-Xing YinLi-Mei YaoWei-Xiong LinJin-Zhen WuDe-Zhai YangHindawi - Cambridge University PressarticleGeneticsQH426-470ENGenetics Research, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Fen-Han Zhang Rui-Xing Yin Li-Mei Yao Wei-Xiong Lin Jin-Zhen Wu De-Zhai Yang Association between the PLTP rs4810479 SNP and Serum Lipid Traits in the Chinese Maonan and Han Populations
description	The association between the phospholipid transfer protein (PLTP) gene rs4810479 single-nucleotide polymorphism (SNP) and serum lipid levels is largely unknown. This investigation aimed to evaluate the relationship between the PLTP rs4810479 SNP, several environmental risk factors, and serum lipid parameters in the Chinese Maonan and Han nationalities. Polymerase chain reaction-restriction fragment length polymorphism, gel electrophoresis, and direct sequencing were employed to determine the PLTP rs4810479 genotypes in 633 Maonan and 646 Han participants. The frequencies of CC, CT, and TT genotypes and the C allele were different between Maonan and Han groups (29.07%, 53.08%, 17.85%, and 55.61% vs. 35.60%, 49.70%, 14.70%, and 60.45%, respectively, P<0.05). The C allele carriers in the Maonan group had higher high-density lipoprotein cholesterol levels than the C allele noncarriers, but this finding was only found in Maonan males but not in females. The C allele carriers in Han males had lower total cholesterol and low-density lipoprotein cholesterol levels than the C allele noncarriers. Serum lipid profiles were also affected by several traditional cardiovascular risk factors in both populations. There might be an ethnic- and/or sex-specific association between the PLTP rs4810479 SNP and serum lipid traits.
format	article
author	Fen-Han Zhang Rui-Xing Yin Li-Mei Yao Wei-Xiong Lin Jin-Zhen Wu De-Zhai Yang
author_facet	Fen-Han Zhang Rui-Xing Yin Li-Mei Yao Wei-Xiong Lin Jin-Zhen Wu De-Zhai Yang
author_sort	Fen-Han Zhang
title	Association between the PLTP rs4810479 SNP and Serum Lipid Traits in the Chinese Maonan and Han Populations
title_short	Association between the PLTP rs4810479 SNP and Serum Lipid Traits in the Chinese Maonan and Han Populations
title_full	Association between the PLTP rs4810479 SNP and Serum Lipid Traits in the Chinese Maonan and Han Populations
title_fullStr	Association between the PLTP rs4810479 SNP and Serum Lipid Traits in the Chinese Maonan and Han Populations
title_full_unstemmed	Association between the PLTP rs4810479 SNP and Serum Lipid Traits in the Chinese Maonan and Han Populations
title_sort	association between the pltp rs4810479 snp and serum lipid traits in the chinese maonan and han populations
publisher	Hindawi - Cambridge University Press
publishDate	2021
url	https://doaj.org/article/f5750c39d63d4a31beec4f469e333b47
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Association between the PLTP rs4810479 SNP and Serum Lipid Traits in the Chinese Maonan and Han Populations

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