Omentectomy Prevents Metabolic Syndrome By Reducing Appetite and Body Weight In A Diet-Induced Obesity Rat Model

Abstract Visceral fat deposition is associated with impairment of glucose and lipid metabolism while leptin levels are frequently related to subcutaneous fat area. At present, there is considerable controversy regarding the role of visceral adipose tissue accumulation in the development of metabolic...

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Autores principales:	Inmaculada García-Ruiz, Pablo Solís-Muñoz, Daniel Fernández-Moreira, Montserrat Grau, Maria Teresa Muñoz-Yagüe, José A. Solís-Herruzo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f578f360b41c472f8cd80940b3c549b1
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spelling	oai:doaj.org-article:f578f360b41c472f8cd80940b3c549b12021-12-02T15:07:52ZOmentectomy Prevents Metabolic Syndrome By Reducing Appetite and Body Weight In A Diet-Induced Obesity Rat Model10.1038/s41598-018-19973-z2045-2322https://doaj.org/article/f578f360b41c472f8cd80940b3c549b12018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19973-zhttps://doaj.org/toc/2045-2322Abstract Visceral fat deposition is associated with impairment of glucose and lipid metabolism while leptin levels are frequently related to subcutaneous fat area. At present, there is considerable controversy regarding the role of visceral adipose tissue accumulation in the development of metabolic syndrome (MS). Here we show the effects of omentectomy on the liver and MS in a diet induced obesity rat model. Our results reveal that undergoing omentectomy previously the establishment of the diet-induced-obesity reduced significantly body weight gain and avoid the development of MS, including non-alcoholic fatty liver disease. Intriguingly, the significantly lower body weight gain was due to decreased food intake. Omentum drives obesity progression through leptin resistance mediated by C-reactive protein, Interleucin (IL)-6 and high lipolysis activity. Omentum removal reversed immediately the increased plasma levels of CRP and IL-6 and gradually food intake, weight gain, and features of MS in diet-induced-obesity. Omentectomy caused no changes in normal-weigh-rats. This report displays causal mechanism by which omentum promotes obesity and propose omentectomy as a promising procedure in MS prevention.Inmaculada García-RuizPablo Solís-MuñozDaniel Fernández-MoreiraMontserrat GrauMaria Teresa Muñoz-YagüeJosé A. Solís-HerruzoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Inmaculada García-Ruiz Pablo Solís-Muñoz Daniel Fernández-Moreira Montserrat Grau Maria Teresa Muñoz-Yagüe José A. Solís-Herruzo Omentectomy Prevents Metabolic Syndrome By Reducing Appetite and Body Weight In A Diet-Induced Obesity Rat Model
description	Abstract Visceral fat deposition is associated with impairment of glucose and lipid metabolism while leptin levels are frequently related to subcutaneous fat area. At present, there is considerable controversy regarding the role of visceral adipose tissue accumulation in the development of metabolic syndrome (MS). Here we show the effects of omentectomy on the liver and MS in a diet induced obesity rat model. Our results reveal that undergoing omentectomy previously the establishment of the diet-induced-obesity reduced significantly body weight gain and avoid the development of MS, including non-alcoholic fatty liver disease. Intriguingly, the significantly lower body weight gain was due to decreased food intake. Omentum drives obesity progression through leptin resistance mediated by C-reactive protein, Interleucin (IL)-6 and high lipolysis activity. Omentum removal reversed immediately the increased plasma levels of CRP and IL-6 and gradually food intake, weight gain, and features of MS in diet-induced-obesity. Omentectomy caused no changes in normal-weigh-rats. This report displays causal mechanism by which omentum promotes obesity and propose omentectomy as a promising procedure in MS prevention.
format	article
author	Inmaculada García-Ruiz Pablo Solís-Muñoz Daniel Fernández-Moreira Montserrat Grau Maria Teresa Muñoz-Yagüe José A. Solís-Herruzo
author_facet	Inmaculada García-Ruiz Pablo Solís-Muñoz Daniel Fernández-Moreira Montserrat Grau Maria Teresa Muñoz-Yagüe José A. Solís-Herruzo
author_sort	Inmaculada García-Ruiz
title	Omentectomy Prevents Metabolic Syndrome By Reducing Appetite and Body Weight In A Diet-Induced Obesity Rat Model
title_short	Omentectomy Prevents Metabolic Syndrome By Reducing Appetite and Body Weight In A Diet-Induced Obesity Rat Model
title_full	Omentectomy Prevents Metabolic Syndrome By Reducing Appetite and Body Weight In A Diet-Induced Obesity Rat Model
title_fullStr	Omentectomy Prevents Metabolic Syndrome By Reducing Appetite and Body Weight In A Diet-Induced Obesity Rat Model
title_full_unstemmed	Omentectomy Prevents Metabolic Syndrome By Reducing Appetite and Body Weight In A Diet-Induced Obesity Rat Model
title_sort	omentectomy prevents metabolic syndrome by reducing appetite and body weight in a diet-induced obesity rat model
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f578f360b41c472f8cd80940b3c549b1
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Omentectomy Prevents Metabolic Syndrome By Reducing Appetite and Body Weight In A Diet-Induced Obesity Rat Model

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