Modification of N-terminal α-amine of proteins via biomimetic ortho-quinone-mediated oxidation

Methods for selective modification of the N-terminus of proteins are of high interest, but mostly require specific amino acid residues. Here, the authors report a selective and fast method for N-terminal modification of proteins based on quinone-mediated oxidation of the alpha-amine to aldehyde or k...

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Autores principales:	Siyao Wang, Qingqing Zhou, Xiaoping Chen, Rong-Hua Luo, Yunxue Li, Xinliang Liu, Liu-Meng Yang, Yong-Tang Zheng, Ping Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f57acc573e8d4c519ae29390bb39b999
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spelling	oai:doaj.org-article:f57acc573e8d4c519ae29390bb39b9992021-12-02T15:51:06ZModification of N-terminal α-amine of proteins via biomimetic ortho-quinone-mediated oxidation10.1038/s41467-021-22654-72041-1723https://doaj.org/article/f57acc573e8d4c519ae29390bb39b9992021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22654-7https://doaj.org/toc/2041-1723Methods for selective modification of the N-terminus of proteins are of high interest, but mostly require specific amino acid residues. Here, the authors report a selective and fast method for N-terminal modification of proteins based on quinone-mediated oxidation of the alpha-amine to aldehyde or ketone, and apply it to diverse proteins.Siyao WangQingqing ZhouXiaoping ChenRong-Hua LuoYunxue LiXinliang LiuLiu-Meng YangYong-Tang ZhengPing WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Siyao Wang Qingqing Zhou Xiaoping Chen Rong-Hua Luo Yunxue Li Xinliang Liu Liu-Meng Yang Yong-Tang Zheng Ping Wang Modification of N-terminal α-amine of proteins via biomimetic ortho-quinone-mediated oxidation
description	Methods for selective modification of the N-terminus of proteins are of high interest, but mostly require specific amino acid residues. Here, the authors report a selective and fast method for N-terminal modification of proteins based on quinone-mediated oxidation of the alpha-amine to aldehyde or ketone, and apply it to diverse proteins.
format	article
author	Siyao Wang Qingqing Zhou Xiaoping Chen Rong-Hua Luo Yunxue Li Xinliang Liu Liu-Meng Yang Yong-Tang Zheng Ping Wang
author_facet	Siyao Wang Qingqing Zhou Xiaoping Chen Rong-Hua Luo Yunxue Li Xinliang Liu Liu-Meng Yang Yong-Tang Zheng Ping Wang
author_sort	Siyao Wang
title	Modification of N-terminal α-amine of proteins via biomimetic ortho-quinone-mediated oxidation
title_short	Modification of N-terminal α-amine of proteins via biomimetic ortho-quinone-mediated oxidation
title_full	Modification of N-terminal α-amine of proteins via biomimetic ortho-quinone-mediated oxidation
title_fullStr	Modification of N-terminal α-amine of proteins via biomimetic ortho-quinone-mediated oxidation
title_full_unstemmed	Modification of N-terminal α-amine of proteins via biomimetic ortho-quinone-mediated oxidation
title_sort	modification of n-terminal α-amine of proteins via biomimetic ortho-quinone-mediated oxidation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f57acc573e8d4c519ae29390bb39b999
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Modification of N-terminal α-amine of proteins via biomimetic ortho-quinone-mediated oxidation

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