Acute kidney injury in patients with pneumonia with A/H1N1 influenza

Background. A critical condition of any genesis may be accompanied by the development of multiple organ failure, one of the manifestations of which is acute renal injury. Often, the process is subclinical in nature and the «classical» approaches to diagnose renal damage by creatinine concentration,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	A. V. Malyarchikov, K. G. Shаpovаlov, S. A. Lukyanov, P. P. Tereshkov, L. S. Kazantseva
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	influenza a/h1n1 aki multiple organ failure ngal cystatin c Science Q
Acceso en línea:	https://doaj.org/article/f57b066c5cb942c1bef70430ec114555
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f57b066c5cb942c1bef70430ec114555
record_format	dspace
spelling	oai:doaj.org-article:f57b066c5cb942c1bef70430ec1145552021-11-23T06:14:46ZAcute kidney injury in patients with pneumonia with A/H1N1 influenza2541-94202587-959610.29413/ABS.2021-6.3.5https://doaj.org/article/f57b066c5cb942c1bef70430ec1145552021-08-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2845https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. A critical condition of any genesis may be accompanied by the development of multiple organ failure, one of the manifestations of which is acute renal injury. Often, the process is subclinical in nature and the «classical» approaches to diagnose renal damage by creatinine concentration, urea level and assessment of glomerular filtration rate may not fully reflect the degree of impaired renal function, while acute kidney injury is a well-known predictor of high hospital mortality among critically ill patients.Aims. The purpose of this study was to assess functional state of the kidneysby determining the serum concentration of the markers of kidney injury NGAL and Cystatin C in patients with pneumonia associated with influenza A/H1N1.Materials and methods. 85 patients with pneumonia associated with influenza A/H1N1 were examined, 30 patients with severe pneumonia, 55 with non-severe pneumonia. The control group was formed by 15 healthy donors. The serum concentration of NGAL and Cystatin C molecules was determined by flow cytometry on a Beckman Coulter analyzer (USA), using a Human Immune Checkpoint Panel 1 multiplex assay kit (Biolegend, USA). The glomerular filtration rate was calculated using the CKD-EPI formula.Results. It was found that in patients with severe pneumonia with the influenza A/H1N1, the concentration of NGAL increased 3.8 times compared with the control group, the concentration of Cystatin C increased 1.4 times, the glomerular filtration rate did not change.Conclusion. Timely diagnosis of subclinical kidney injury makes it possible to objectify the severity of the condition, make adjustments to therapy, which can help to an increase in the survival rate of critically ill patients.A. V. MalyarchikovK. G. ShаpovаlovS. A. LukyanovP. P. TereshkovL. S. KazantsevaScientific Сentre for Family Health and Human Reproduction Problemsarticleinfluenza a/h1n1akimultiple organ failurengalcystatin cScienceQRUActa Biomedica Scientifica, Vol 6, Iss 3, Pp 53-59 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	influenza a/h1n1 aki multiple organ failure ngal cystatin c Science Q
spellingShingle	influenza a/h1n1 aki multiple organ failure ngal cystatin c Science Q A. V. Malyarchikov K. G. Shаpovаlov S. A. Lukyanov P. P. Tereshkov L. S. Kazantseva Acute kidney injury in patients with pneumonia with A/H1N1 influenza
description	Background. A critical condition of any genesis may be accompanied by the development of multiple organ failure, one of the manifestations of which is acute renal injury. Often, the process is subclinical in nature and the «classical» approaches to diagnose renal damage by creatinine concentration, urea level and assessment of glomerular filtration rate may not fully reflect the degree of impaired renal function, while acute kidney injury is a well-known predictor of high hospital mortality among critically ill patients.Aims. The purpose of this study was to assess functional state of the kidneysby determining the serum concentration of the markers of kidney injury NGAL and Cystatin C in patients with pneumonia associated with influenza A/H1N1.Materials and methods. 85 patients with pneumonia associated with influenza A/H1N1 were examined, 30 patients with severe pneumonia, 55 with non-severe pneumonia. The control group was formed by 15 healthy donors. The serum concentration of NGAL and Cystatin C molecules was determined by flow cytometry on a Beckman Coulter analyzer (USA), using a Human Immune Checkpoint Panel 1 multiplex assay kit (Biolegend, USA). The glomerular filtration rate was calculated using the CKD-EPI formula.Results. It was found that in patients with severe pneumonia with the influenza A/H1N1, the concentration of NGAL increased 3.8 times compared with the control group, the concentration of Cystatin C increased 1.4 times, the glomerular filtration rate did not change.Conclusion. Timely diagnosis of subclinical kidney injury makes it possible to objectify the severity of the condition, make adjustments to therapy, which can help to an increase in the survival rate of critically ill patients.
format	article
author	A. V. Malyarchikov K. G. Shаpovаlov S. A. Lukyanov P. P. Tereshkov L. S. Kazantseva
author_facet	A. V. Malyarchikov K. G. Shаpovаlov S. A. Lukyanov P. P. Tereshkov L. S. Kazantseva
author_sort	A. V. Malyarchikov
title	Acute kidney injury in patients with pneumonia with A/H1N1 influenza
title_short	Acute kidney injury in patients with pneumonia with A/H1N1 influenza
title_full	Acute kidney injury in patients with pneumonia with A/H1N1 influenza
title_fullStr	Acute kidney injury in patients with pneumonia with A/H1N1 influenza
title_full_unstemmed	Acute kidney injury in patients with pneumonia with A/H1N1 influenza
title_sort	acute kidney injury in patients with pneumonia with a/h1n1 influenza
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/f57b066c5cb942c1bef70430ec114555
work_keys_str_mv	AT avmalyarchikov acutekidneyinjuryinpatientswithpneumoniawithah1n1influenza AT kgshapovalov acutekidneyinjuryinpatientswithpneumoniawithah1n1influenza AT salukyanov acutekidneyinjuryinpatientswithpneumoniawithah1n1influenza AT pptereshkov acutekidneyinjuryinpatientswithpneumoniawithah1n1influenza AT lskazantseva acutekidneyinjuryinpatientswithpneumoniawithah1n1influenza
_version_	1718416920742461440

Acute kidney injury in patients with pneumonia with A/H1N1 influenza

Ejemplares similares