3′HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression
Mutations in the adult β-globin gene can lead to a variety of hemoglobinopathies, including sickle cell disease and β-thalassemia. An increase in fetal hemoglobin expression throughout adulthood, a condition named hereditary persistence of fetal hemoglobin (HPFH), has been found to ameliorate hemogl...
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| Auteurs principaux: | , , , , , , , , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
eLife Sciences Publications Ltd
2021
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| Sujets: | |
| Accès en ligne: | https://doaj.org/article/f57b54ffcd06452fa3926ecc23940b5f |
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