Antibiotic residues in cattle and sheep meat and human exposure assessment in southern Xinjiang, China

Abstract In recent years, antibiotics have become widely used in animal breeding. The application of antibiotics in livestock may lead to the presence of antibiotic residues in animal‐derived foods, especially meat, that may pose a threat to human health. In this study, 26 common antibiotics (eight...

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Autores principales:	Yu Zhang, Jianjiang Lu, Yujun Yan, Jinhua Liu, Manli Wang
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	antibiotic residues cattle and sheep meat dietary exposure assessment food safety southern Xinjiang Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/f5863ff3da9c43098980eca340346c54
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spelling	oai:doaj.org-article:f5863ff3da9c43098980eca340346c542021-11-04T13:06:43ZAntibiotic residues in cattle and sheep meat and human exposure assessment in southern Xinjiang, China2048-717710.1002/fsn3.2568https://doaj.org/article/f5863ff3da9c43098980eca340346c542021-11-01T00:00:00Zhttps://doi.org/10.1002/fsn3.2568https://doaj.org/toc/2048-7177Abstract In recent years, antibiotics have become widely used in animal breeding. The application of antibiotics in livestock may lead to the presence of antibiotic residues in animal‐derived foods, especially meat, that may pose a threat to human health. In this study, 26 common antibiotics (eight sulfonamides, nine fluoroquinolones, four tetracyclines, and five macrolides) were screened in 88 meat samples (cattle muscles and sheep muscles, kidneys, and livers) obtained from southern Xinjiang. The antibiotics were screened via the clean‐up step based on solid‐phase extraction and determined through ultraperformance liquid chromatography–tandem mass spectrometry. Moreover, their risk to human health was analyzed. Overall, 16 antibiotics were detected with a total detection rate of 95.46%. The percentage of noncompliant samples was 28.41% with an exceedance maximum residue limit of 1.14%. The illegal use rate of the antibiotic norfloxacin was 27.27%. The estimated daily exposure doses of all compounds in adults were <102.218 ng/kg bw/day even after applying the worst‐case scenario approach. This result demonstrated that the antibiotic residues in the tested samples imposed negligible harm to people's health and had an acceptable level of food safety risk. However, the high detection frequencies found in this work indicated that the risk of antibiotic residues could not be ignored given the cumulative risk of antibiotics, particularly the emergence of bacterial resistance, to the human body. The need for effective strategies and publicity for the judicious use of antibiotics to safeguard residents’ health is immediate.Yu ZhangJianjiang LuYujun YanJinhua LiuManli WangWileyarticleantibiotic residuescattle and sheep meatdietary exposure assessmentfood safetysouthern XinjiangNutrition. Foods and food supplyTX341-641ENFood Science & Nutrition, Vol 9, Iss 11, Pp 6152-6161 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibiotic residues cattle and sheep meat dietary exposure assessment food safety southern Xinjiang Nutrition. Foods and food supply TX341-641
spellingShingle	antibiotic residues cattle and sheep meat dietary exposure assessment food safety southern Xinjiang Nutrition. Foods and food supply TX341-641 Yu Zhang Jianjiang Lu Yujun Yan Jinhua Liu Manli Wang Antibiotic residues in cattle and sheep meat and human exposure assessment in southern Xinjiang, China
description	Abstract In recent years, antibiotics have become widely used in animal breeding. The application of antibiotics in livestock may lead to the presence of antibiotic residues in animal‐derived foods, especially meat, that may pose a threat to human health. In this study, 26 common antibiotics (eight sulfonamides, nine fluoroquinolones, four tetracyclines, and five macrolides) were screened in 88 meat samples (cattle muscles and sheep muscles, kidneys, and livers) obtained from southern Xinjiang. The antibiotics were screened via the clean‐up step based on solid‐phase extraction and determined through ultraperformance liquid chromatography–tandem mass spectrometry. Moreover, their risk to human health was analyzed. Overall, 16 antibiotics were detected with a total detection rate of 95.46%. The percentage of noncompliant samples was 28.41% with an exceedance maximum residue limit of 1.14%. The illegal use rate of the antibiotic norfloxacin was 27.27%. The estimated daily exposure doses of all compounds in adults were <102.218 ng/kg bw/day even after applying the worst‐case scenario approach. This result demonstrated that the antibiotic residues in the tested samples imposed negligible harm to people's health and had an acceptable level of food safety risk. However, the high detection frequencies found in this work indicated that the risk of antibiotic residues could not be ignored given the cumulative risk of antibiotics, particularly the emergence of bacterial resistance, to the human body. The need for effective strategies and publicity for the judicious use of antibiotics to safeguard residents’ health is immediate.
format	article
author	Yu Zhang Jianjiang Lu Yujun Yan Jinhua Liu Manli Wang
author_facet	Yu Zhang Jianjiang Lu Yujun Yan Jinhua Liu Manli Wang
author_sort	Yu Zhang
title	Antibiotic residues in cattle and sheep meat and human exposure assessment in southern Xinjiang, China
title_short	Antibiotic residues in cattle and sheep meat and human exposure assessment in southern Xinjiang, China
title_full	Antibiotic residues in cattle and sheep meat and human exposure assessment in southern Xinjiang, China
title_fullStr	Antibiotic residues in cattle and sheep meat and human exposure assessment in southern Xinjiang, China
title_full_unstemmed	Antibiotic residues in cattle and sheep meat and human exposure assessment in southern Xinjiang, China
title_sort	antibiotic residues in cattle and sheep meat and human exposure assessment in southern xinjiang, china
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/f5863ff3da9c43098980eca340346c54
work_keys_str_mv	AT yuzhang antibioticresiduesincattleandsheepmeatandhumanexposureassessmentinsouthernxinjiangchina AT jianjianglu antibioticresiduesincattleandsheepmeatandhumanexposureassessmentinsouthernxinjiangchina AT yujunyan antibioticresiduesincattleandsheepmeatandhumanexposureassessmentinsouthernxinjiangchina AT jinhualiu antibioticresiduesincattleandsheepmeatandhumanexposureassessmentinsouthernxinjiangchina AT manliwang antibioticresiduesincattleandsheepmeatandhumanexposureassessmentinsouthernxinjiangchina
_version_	1718444938045161472

Antibiotic residues in cattle and sheep meat and human exposure assessment in southern Xinjiang, China

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