Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling

Nonalcoholic steatohepatitis (NASH) and dietary cholesterol are risk factors for hepatocellular carcinoma (HCC). Here, the authors utilise mouse models to show that dietary cholesterol induces NASH by deregulating genes involved in metabolism, inflammation and calcium signaling to induce NASH-HCC.

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Autores principales:	Jessie Qiaoyi Liang, Narcissus Teoh, Lixia Xu, Sharon Pok, Xiangchun Li, Eagle S. H. Chu, Jonathan Chiu, Ling Dong, Evi Arfianti, W. Geoffrey Haigh, Matthew M. Yeh, George N. Ioannou, Joseph J. Y. Sung, Geoffrey Farrell, Jun Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f586a8b5cf4f4dbbb56141228ef1c3be
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spelling	oai:doaj.org-article:f586a8b5cf4f4dbbb56141228ef1c3be2021-12-02T15:34:43ZDietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling10.1038/s41467-018-06931-62041-1723https://doaj.org/article/f586a8b5cf4f4dbbb56141228ef1c3be2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06931-6https://doaj.org/toc/2041-1723Nonalcoholic steatohepatitis (NASH) and dietary cholesterol are risk factors for hepatocellular carcinoma (HCC). Here, the authors utilise mouse models to show that dietary cholesterol induces NASH by deregulating genes involved in metabolism, inflammation and calcium signaling to induce NASH-HCC.Jessie Qiaoyi LiangNarcissus TeohLixia XuSharon PokXiangchun LiEagle S. H. ChuJonathan ChiuLing DongEvi ArfiantiW. Geoffrey HaighMatthew M. YehGeorge N. IoannouJoseph J. Y. SungGeoffrey FarrellJun YuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jessie Qiaoyi Liang Narcissus Teoh Lixia Xu Sharon Pok Xiangchun Li Eagle S. H. Chu Jonathan Chiu Ling Dong Evi Arfianti W. Geoffrey Haigh Matthew M. Yeh George N. Ioannou Joseph J. Y. Sung Geoffrey Farrell Jun Yu Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling
description	Nonalcoholic steatohepatitis (NASH) and dietary cholesterol are risk factors for hepatocellular carcinoma (HCC). Here, the authors utilise mouse models to show that dietary cholesterol induces NASH by deregulating genes involved in metabolism, inflammation and calcium signaling to induce NASH-HCC.
format	article
author	Jessie Qiaoyi Liang Narcissus Teoh Lixia Xu Sharon Pok Xiangchun Li Eagle S. H. Chu Jonathan Chiu Ling Dong Evi Arfianti W. Geoffrey Haigh Matthew M. Yeh George N. Ioannou Joseph J. Y. Sung Geoffrey Farrell Jun Yu
author_facet	Jessie Qiaoyi Liang Narcissus Teoh Lixia Xu Sharon Pok Xiangchun Li Eagle S. H. Chu Jonathan Chiu Ling Dong Evi Arfianti W. Geoffrey Haigh Matthew M. Yeh George N. Ioannou Joseph J. Y. Sung Geoffrey Farrell Jun Yu
author_sort	Jessie Qiaoyi Liang
title	Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling
title_short	Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling
title_full	Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling
title_fullStr	Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling
title_full_unstemmed	Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling
title_sort	dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f586a8b5cf4f4dbbb56141228ef1c3be
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Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling

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