Risk factors for subjective cognitive decline: the CABLE study

Abstract Increasing evidences supported that subjective cognitive decline (SCD) might be a potential first symptomatic manifestation of Alzheimer’s disease (AD). The rapidly growing number of SCD individuals who seek medical help and advice also makes it urgent to develop more precise strategy for S...

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Autores principales:	Chen Wen, Hao Hu, Ya-Nan Ou, Yan-Lin Bi, Ya-Hui Ma, Lan Tan, Jin-Tai Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/f5879a43cfe0498aa6a0a9f2ce0ec52a
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spelling	oai:doaj.org-article:f5879a43cfe0498aa6a0a9f2ce0ec52a2021-11-14T12:11:22ZRisk factors for subjective cognitive decline: the CABLE study10.1038/s41398-021-01711-12158-3188https://doaj.org/article/f5879a43cfe0498aa6a0a9f2ce0ec52a2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41398-021-01711-1https://doaj.org/toc/2158-3188Abstract Increasing evidences supported that subjective cognitive decline (SCD) might be a potential first symptomatic manifestation of Alzheimer’s disease (AD). The rapidly growing number of SCD individuals who seek medical help and advice also makes it urgent to develop more precise strategy for SCD. Therefore, this study aimed to explore the risk factors for SCD. Logistics and linear regression models were performed to investigate 41 factors for SCD in 1165 participants without objective cognitive impairment. Cochran-Armitage trend test was used to confirm the constant trend toward higher prevalence of SCD with an increasing number of risk factors. A high overall prevalence of SCD was found in total participants (42%). Eight factors were eventually identified as risk factors for SCD, including four stable factors associated with both SCD statues and severity (older age, thyroid diseases, minimal anxiety symptoms, and day time dysfunction; odds ratio (OR) ranging from 1.74 to 2.29) as well as four suggestive factors associated with either SCD statues or severity (female sex, anemia, lack of physical exercises, and living alone; OR ranging from 1.30 to 2.29). The prevalence of SCD gradually increased with the number of risk factors clustering increased in individuals (p for trend <0.001). Five of these eight factors were further proved among individuals with SCD-plus features. These findings revealed several risk factors for SCD, providing some new clues for formulating priority strategies for early prevention of SCD.Chen WenHao HuYa-Nan OuYan-Lin BiYa-Hui MaLan TanJin-Tai YuNature Publishing GrouparticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Chen Wen Hao Hu Ya-Nan Ou Yan-Lin Bi Ya-Hui Ma Lan Tan Jin-Tai Yu Risk factors for subjective cognitive decline: the CABLE study
description	Abstract Increasing evidences supported that subjective cognitive decline (SCD) might be a potential first symptomatic manifestation of Alzheimer’s disease (AD). The rapidly growing number of SCD individuals who seek medical help and advice also makes it urgent to develop more precise strategy for SCD. Therefore, this study aimed to explore the risk factors for SCD. Logistics and linear regression models were performed to investigate 41 factors for SCD in 1165 participants without objective cognitive impairment. Cochran-Armitage trend test was used to confirm the constant trend toward higher prevalence of SCD with an increasing number of risk factors. A high overall prevalence of SCD was found in total participants (42%). Eight factors were eventually identified as risk factors for SCD, including four stable factors associated with both SCD statues and severity (older age, thyroid diseases, minimal anxiety symptoms, and day time dysfunction; odds ratio (OR) ranging from 1.74 to 2.29) as well as four suggestive factors associated with either SCD statues or severity (female sex, anemia, lack of physical exercises, and living alone; OR ranging from 1.30 to 2.29). The prevalence of SCD gradually increased with the number of risk factors clustering increased in individuals (p for trend <0.001). Five of these eight factors were further proved among individuals with SCD-plus features. These findings revealed several risk factors for SCD, providing some new clues for formulating priority strategies for early prevention of SCD.
format	article
author	Chen Wen Hao Hu Ya-Nan Ou Yan-Lin Bi Ya-Hui Ma Lan Tan Jin-Tai Yu
author_facet	Chen Wen Hao Hu Ya-Nan Ou Yan-Lin Bi Ya-Hui Ma Lan Tan Jin-Tai Yu
author_sort	Chen Wen
title	Risk factors for subjective cognitive decline: the CABLE study
title_short	Risk factors for subjective cognitive decline: the CABLE study
title_full	Risk factors for subjective cognitive decline: the CABLE study
title_fullStr	Risk factors for subjective cognitive decline: the CABLE study
title_full_unstemmed	Risk factors for subjective cognitive decline: the CABLE study
title_sort	risk factors for subjective cognitive decline: the cable study
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/f5879a43cfe0498aa6a0a9f2ce0ec52a
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Risk factors for subjective cognitive decline: the CABLE study

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