Advanced biofabrication strategies for biomimetic composite scaffolds to regenerate ligament‐bone interface

Abstract The natural ligament–bone interface features gradient changes in matrix composition, architecture and cell phenotype, which play critical roles in reliable ligament fixation and smooth loading transfer. Mimicking such organisations in artificial composite tissue‐engineering scaffolds is imp...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nan Jiang, Mao Mao, Xiao Li, Weijie Zhang, Jiankang He, Dichen Li
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	biofabrication biomimetic composite scaffolds gradient scaffolds ligament stratified scaffolds Biotechnology TP248.13-248.65 Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/f58fbe6ad36a41b5b4fbdcc6e0f1de99
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f58fbe6ad36a41b5b4fbdcc6e0f1de99
record_format	dspace
spelling	oai:doaj.org-article:f58fbe6ad36a41b5b4fbdcc6e0f1de992021-11-12T15:58:03ZAdvanced biofabrication strategies for biomimetic composite scaffolds to regenerate ligament‐bone interface2405-451810.1049/bsb2.12021https://doaj.org/article/f58fbe6ad36a41b5b4fbdcc6e0f1de992021-12-01T00:00:00Zhttps://doi.org/10.1049/bsb2.12021https://doaj.org/toc/2405-4518Abstract The natural ligament–bone interface features gradient changes in matrix composition, architecture and cell phenotype, which play critical roles in reliable ligament fixation and smooth loading transfer. Mimicking such organisations in artificial composite tissue‐engineering scaffolds is important for realising functional fixation between ligament implants and host bones. Here, the authors aim to provide a comprehensive review on the latest strategies to fabricate biomimetic composite scaffolds for the regeneration of ligament‐to‐bone interface. The biomimetic composite scaffolds are divided into stratified and gradient scaffolds, which are characterised as layer‐specific and continuous changes, respectively, in scaffold materials and/or microstructures. Biofabrication strategies for different types of composite scaffolds are summarised. The effects of material/structural changes on cellular morphology, cell differentiation, in vivo osteointegration and multi‐tissue interface regeneration are highlighted. Finally, the potential challenges and future perspectives in engineering biomimetic composite scaffolds for ligament–bone interface regeneration are discussed.Nan JiangMao MaoXiao LiWeijie ZhangJiankang HeDichen LiWileyarticlebiofabricationbiomimetic composite scaffoldsgradient scaffoldsligamentstratified scaffoldsBiotechnologyTP248.13-248.65BiochemistryQD415-436ENBiosurface and Biotribology, Vol 7, Iss 4, Pp 187-205 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biofabrication biomimetic composite scaffolds gradient scaffolds ligament stratified scaffolds Biotechnology TP248.13-248.65 Biochemistry QD415-436
spellingShingle	biofabrication biomimetic composite scaffolds gradient scaffolds ligament stratified scaffolds Biotechnology TP248.13-248.65 Biochemistry QD415-436 Nan Jiang Mao Mao Xiao Li Weijie Zhang Jiankang He Dichen Li Advanced biofabrication strategies for biomimetic composite scaffolds to regenerate ligament‐bone interface
description	Abstract The natural ligament–bone interface features gradient changes in matrix composition, architecture and cell phenotype, which play critical roles in reliable ligament fixation and smooth loading transfer. Mimicking such organisations in artificial composite tissue‐engineering scaffolds is important for realising functional fixation between ligament implants and host bones. Here, the authors aim to provide a comprehensive review on the latest strategies to fabricate biomimetic composite scaffolds for the regeneration of ligament‐to‐bone interface. The biomimetic composite scaffolds are divided into stratified and gradient scaffolds, which are characterised as layer‐specific and continuous changes, respectively, in scaffold materials and/or microstructures. Biofabrication strategies for different types of composite scaffolds are summarised. The effects of material/structural changes on cellular morphology, cell differentiation, in vivo osteointegration and multi‐tissue interface regeneration are highlighted. Finally, the potential challenges and future perspectives in engineering biomimetic composite scaffolds for ligament–bone interface regeneration are discussed.
format	article
author	Nan Jiang Mao Mao Xiao Li Weijie Zhang Jiankang He Dichen Li
author_facet	Nan Jiang Mao Mao Xiao Li Weijie Zhang Jiankang He Dichen Li
author_sort	Nan Jiang
title	Advanced biofabrication strategies for biomimetic composite scaffolds to regenerate ligament‐bone interface
title_short	Advanced biofabrication strategies for biomimetic composite scaffolds to regenerate ligament‐bone interface
title_full	Advanced biofabrication strategies for biomimetic composite scaffolds to regenerate ligament‐bone interface
title_fullStr	Advanced biofabrication strategies for biomimetic composite scaffolds to regenerate ligament‐bone interface
title_full_unstemmed	Advanced biofabrication strategies for biomimetic composite scaffolds to regenerate ligament‐bone interface
title_sort	advanced biofabrication strategies for biomimetic composite scaffolds to regenerate ligament‐bone interface
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/f58fbe6ad36a41b5b4fbdcc6e0f1de99
work_keys_str_mv	AT nanjiang advancedbiofabricationstrategiesforbiomimeticcompositescaffoldstoregenerateligamentboneinterface AT maomao advancedbiofabricationstrategiesforbiomimeticcompositescaffoldstoregenerateligamentboneinterface AT xiaoli advancedbiofabricationstrategiesforbiomimeticcompositescaffoldstoregenerateligamentboneinterface AT weijiezhang advancedbiofabricationstrategiesforbiomimeticcompositescaffoldstoregenerateligamentboneinterface AT jiankanghe advancedbiofabricationstrategiesforbiomimeticcompositescaffoldstoregenerateligamentboneinterface AT dichenli advancedbiofabricationstrategiesforbiomimeticcompositescaffoldstoregenerateligamentboneinterface
_version_	1718430409273901056

Advanced biofabrication strategies for biomimetic composite scaffolds to regenerate ligament‐bone interface

Ejemplares similares