Biomarkers for depression: recent insights, current challenges and future prospects

Rebecca Strawbridge,1 Allan H Young,1,2 Anthony J Cleare1,2 1Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, 2South London and Maudsley NHS Foundation Trust, London, UK Abstract: A plethora...

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Autores principales:	Strawbridge R, Young AH, Cleare AJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	mood disorder major depressive disorder inflammation treatment response stratification personalized medicine Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f59815e2d52047cea9e4c56191c869f2
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spelling	oai:doaj.org-article:f59815e2d52047cea9e4c56191c869f22021-12-02T04:46:27ZBiomarkers for depression: recent insights, current challenges and future prospects1178-2021https://doaj.org/article/f59815e2d52047cea9e4c56191c869f22017-05-01T00:00:00Zhttps://www.dovepress.com/biomarkers-for-depression-recent-insights-current-challenges-and-futur-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Rebecca Strawbridge,1 Allan H Young,1,2 Anthony J Cleare1,2 1Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, 2South London and Maudsley NHS Foundation Trust, London, UK Abstract: A plethora of research has implicated hundreds of putative biomarkers for depression, but has not yet fully elucidated their roles in depressive illness or established what is abnormal in which patients and how biologic information can be used to enhance diagnosis, treatment and prognosis. This lack of progress is partially due to the nature and heterogeneity of depression, in conjunction with methodological heterogeneity within the research literature and the large array of biomarkers with potential, the expression of which often varies according to many factors. We review the available literature, which indicates that markers involved in inflammatory, neurotrophic and metabolic processes, as well as neurotransmitter and neuroendocrine system components, represent highly promising candidates. These may be measured through genetic and epigenetic, transcriptomic and proteomic, metabolomic and neuroimaging assessments. The use of novel approaches and systematic research programs is now required to determine whether, and which, biomarkers can be used to predict response to treatment, stratify patients to specific treatments and develop targets for new interventions. We conclude that there is much promise for reducing the burden of depression through further developing and expanding these research avenues. Keywords: mood disorder, major depressive disorder, inflammation, treatment response, stratification, personalized medicineStrawbridge RYoung AHCleare AJDove Medical Pressarticlemood disordermajor depressive disorderinflammationtreatment responsestratificationpersonalized medicineNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 1245-1262 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	mood disorder major depressive disorder inflammation treatment response stratification personalized medicine Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	mood disorder major depressive disorder inflammation treatment response stratification personalized medicine Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Strawbridge R Young AH Cleare AJ Biomarkers for depression: recent insights, current challenges and future prospects
description	Rebecca Strawbridge,1 Allan H Young,1,2 Anthony J Cleare1,2 1Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, 2South London and Maudsley NHS Foundation Trust, London, UK Abstract: A plethora of research has implicated hundreds of putative biomarkers for depression, but has not yet fully elucidated their roles in depressive illness or established what is abnormal in which patients and how biologic information can be used to enhance diagnosis, treatment and prognosis. This lack of progress is partially due to the nature and heterogeneity of depression, in conjunction with methodological heterogeneity within the research literature and the large array of biomarkers with potential, the expression of which often varies according to many factors. We review the available literature, which indicates that markers involved in inflammatory, neurotrophic and metabolic processes, as well as neurotransmitter and neuroendocrine system components, represent highly promising candidates. These may be measured through genetic and epigenetic, transcriptomic and proteomic, metabolomic and neuroimaging assessments. The use of novel approaches and systematic research programs is now required to determine whether, and which, biomarkers can be used to predict response to treatment, stratify patients to specific treatments and develop targets for new interventions. We conclude that there is much promise for reducing the burden of depression through further developing and expanding these research avenues. Keywords: mood disorder, major depressive disorder, inflammation, treatment response, stratification, personalized medicine
format	article
author	Strawbridge R Young AH Cleare AJ
author_facet	Strawbridge R Young AH Cleare AJ
author_sort	Strawbridge R
title	Biomarkers for depression: recent insights, current challenges and future prospects
title_short	Biomarkers for depression: recent insights, current challenges and future prospects
title_full	Biomarkers for depression: recent insights, current challenges and future prospects
title_fullStr	Biomarkers for depression: recent insights, current challenges and future prospects
title_full_unstemmed	Biomarkers for depression: recent insights, current challenges and future prospects
title_sort	biomarkers for depression: recent insights, current challenges and future prospects
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/f59815e2d52047cea9e4c56191c869f2
work_keys_str_mv	AT strawbridger biomarkersfordepressionrecentinsightscurrentchallengesandfutureprospects AT youngah biomarkersfordepressionrecentinsightscurrentchallengesandfutureprospects AT cleareaj biomarkersfordepressionrecentinsightscurrentchallengesandfutureprospects
_version_	1718401073881808896

Biomarkers for depression: recent insights, current challenges and future prospects

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