Experimental gingivitis induces systemic inflammatory markers in young healthy individuals: a single-subject interventional study.

<h4>Objectives</h4>We here investigated whether experimental gingivitis enhances systemic markers of inflammation which are also known as surrogate markers of atherosclerotic plaque development.<h4>Background</h4>Gingivitis is a low-level oral infection induced by bacterial d...

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Autores principales: Jörg Eberhard, Karsten Grote, Maren Luchtefeld, Wieland Heuer, Harald Schuett, Dimitar Divchev, Ralph Scherer, Ruth Schmitz-Streit, Daniela Langfeldt, Nico Stumpp, Ingmar Staufenbiel, Bernhard Schieffer, Meike Stiesch
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Publicado: Public Library of Science (PLoS) 2013
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spelling oai:doaj.org-article:f598b0ba59e34ff59b1ebc523098a44d2021-11-18T07:58:23ZExperimental gingivitis induces systemic inflammatory markers in young healthy individuals: a single-subject interventional study.1932-620310.1371/journal.pone.0055265https://doaj.org/article/f598b0ba59e34ff59b1ebc523098a44d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23408963/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>We here investigated whether experimental gingivitis enhances systemic markers of inflammation which are also known as surrogate markers of atherosclerotic plaque development.<h4>Background</h4>Gingivitis is a low-level oral infection induced by bacterial deposits with a high prevalence within Western populations. A potential link between the more severe oral disease periodontitis and cardiovascular disease has already been shown.<h4>Methods</h4>37 non-smoking young volunteers with no inflammatory disease or any cardiovascular risk factors participated in this single-subject interventional study with an intra-individual control. Intentionally experimental oral inflammation was induced by the interruption of oral hygiene for 21 days, followed by a 21-days resolving phase after reinitiation of oral hygiene. Primary outcome measures at baseline, day 21 and 42 were concentrations of hsCRP, IL-6, and MCP-1, as well as adhesion capacity and oxLDL uptake of isolated blood monocytes.<h4>Results</h4>The partial cessation of oral hygiene procedures was followed by the significant increase of gingival bleeding (34.0%, P<0.0001). This local inflammation was associated with a systemic increase in hsCRP (0.24 mg/L, P = 0.038), IL-6 (12.52 ng/L, P = 0.0002) and MCP-1 (9.10 ng/l, P = 0.124) in peripheral blood samples between baseline and day 21, which decreased at day 42. Monocytes showed an enhanced adherence to endothelial cells and increased foam cell formation after oxLDL uptake (P<0.050) at day 21 of gingivitis.<h4>Conclusions</h4>Bacterial-induced gingival low-level inflammation induced a systemic increase in inflammatory markers. Dental hygiene almost completely reversed this experimental inflammatory process, suggesting that appropriate dental prophylaxis may also limit systemic markers of inflammation in subjects with natural gingivitis. International Clinical Trials Register Platform of the World Health Organization, registry number: DRKS00003366, URL: http://apps.who.int/trialsearch/Default.aspx.Jörg EberhardKarsten GroteMaren LuchtefeldWieland HeuerHarald SchuettDimitar DivchevRalph SchererRuth Schmitz-StreitDaniela LangfeldtNico StumppIngmar StaufenbielBernhard SchiefferMeike StieschPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e55265 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Jörg Eberhard
Karsten Grote
Maren Luchtefeld
Wieland Heuer
Harald Schuett
Dimitar Divchev
Ralph Scherer
Ruth Schmitz-Streit
Daniela Langfeldt
Nico Stumpp
Ingmar Staufenbiel
Bernhard Schieffer
Meike Stiesch
Experimental gingivitis induces systemic inflammatory markers in young healthy individuals: a single-subject interventional study.
description <h4>Objectives</h4>We here investigated whether experimental gingivitis enhances systemic markers of inflammation which are also known as surrogate markers of atherosclerotic plaque development.<h4>Background</h4>Gingivitis is a low-level oral infection induced by bacterial deposits with a high prevalence within Western populations. A potential link between the more severe oral disease periodontitis and cardiovascular disease has already been shown.<h4>Methods</h4>37 non-smoking young volunteers with no inflammatory disease or any cardiovascular risk factors participated in this single-subject interventional study with an intra-individual control. Intentionally experimental oral inflammation was induced by the interruption of oral hygiene for 21 days, followed by a 21-days resolving phase after reinitiation of oral hygiene. Primary outcome measures at baseline, day 21 and 42 were concentrations of hsCRP, IL-6, and MCP-1, as well as adhesion capacity and oxLDL uptake of isolated blood monocytes.<h4>Results</h4>The partial cessation of oral hygiene procedures was followed by the significant increase of gingival bleeding (34.0%, P<0.0001). This local inflammation was associated with a systemic increase in hsCRP (0.24 mg/L, P = 0.038), IL-6 (12.52 ng/L, P = 0.0002) and MCP-1 (9.10 ng/l, P = 0.124) in peripheral blood samples between baseline and day 21, which decreased at day 42. Monocytes showed an enhanced adherence to endothelial cells and increased foam cell formation after oxLDL uptake (P<0.050) at day 21 of gingivitis.<h4>Conclusions</h4>Bacterial-induced gingival low-level inflammation induced a systemic increase in inflammatory markers. Dental hygiene almost completely reversed this experimental inflammatory process, suggesting that appropriate dental prophylaxis may also limit systemic markers of inflammation in subjects with natural gingivitis. International Clinical Trials Register Platform of the World Health Organization, registry number: DRKS00003366, URL: http://apps.who.int/trialsearch/Default.aspx.
format article
author Jörg Eberhard
Karsten Grote
Maren Luchtefeld
Wieland Heuer
Harald Schuett
Dimitar Divchev
Ralph Scherer
Ruth Schmitz-Streit
Daniela Langfeldt
Nico Stumpp
Ingmar Staufenbiel
Bernhard Schieffer
Meike Stiesch
author_facet Jörg Eberhard
Karsten Grote
Maren Luchtefeld
Wieland Heuer
Harald Schuett
Dimitar Divchev
Ralph Scherer
Ruth Schmitz-Streit
Daniela Langfeldt
Nico Stumpp
Ingmar Staufenbiel
Bernhard Schieffer
Meike Stiesch
author_sort Jörg Eberhard
title Experimental gingivitis induces systemic inflammatory markers in young healthy individuals: a single-subject interventional study.
title_short Experimental gingivitis induces systemic inflammatory markers in young healthy individuals: a single-subject interventional study.
title_full Experimental gingivitis induces systemic inflammatory markers in young healthy individuals: a single-subject interventional study.
title_fullStr Experimental gingivitis induces systemic inflammatory markers in young healthy individuals: a single-subject interventional study.
title_full_unstemmed Experimental gingivitis induces systemic inflammatory markers in young healthy individuals: a single-subject interventional study.
title_sort experimental gingivitis induces systemic inflammatory markers in young healthy individuals: a single-subject interventional study.
publisher Public Library of Science (PLoS)
publishDate 2013
url https://doaj.org/article/f598b0ba59e34ff59b1ebc523098a44d
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