The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation

IL-33 orchestrates type 2 immunity in allergic asthma. Here the authors show, using biochemical, structural and patient data, that upon IL-33 or allergic challenge, the isomerase Pin1 modifies IRAK-M to control the production of pro-inflammatory cytokines in the setting of airway inflammation.

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Autores principales:	Morris Nechama, Jeahoo Kwon, Shuo Wei, Adrian Tun Kyi, Robert S. Welner, Iddo Z. Ben-Dov, Mohamed S. Arredouani, John M. Asara, Chun-Hau Chen, Cheng-Yu Tsai, Kyle F. Nelson, Koichi S Kobayashi, Elliot Israel, Xiao Zhen Zhou, Linda K. Nicholson, Kun Ping Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f59a26dd71a44b3c90785a69ce33bbf8
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spelling	oai:doaj.org-article:f59a26dd71a44b3c90785a69ce33bbf82021-12-02T16:50:10ZThe IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation10.1038/s41467-018-03886-62041-1723https://doaj.org/article/f59a26dd71a44b3c90785a69ce33bbf82018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03886-6https://doaj.org/toc/2041-1723IL-33 orchestrates type 2 immunity in allergic asthma. Here the authors show, using biochemical, structural and patient data, that upon IL-33 or allergic challenge, the isomerase Pin1 modifies IRAK-M to control the production of pro-inflammatory cytokines in the setting of airway inflammation.Morris NechamaJeahoo KwonShuo WeiAdrian Tun KyiRobert S. WelnerIddo Z. Ben-DovMohamed S. ArredouaniJohn M. AsaraChun-Hau ChenCheng-Yu TsaiKyle F. NelsonKoichi S KobayashiElliot IsraelXiao Zhen ZhouLinda K. NicholsonKun Ping LuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Morris Nechama Jeahoo Kwon Shuo Wei Adrian Tun Kyi Robert S. Welner Iddo Z. Ben-Dov Mohamed S. Arredouani John M. Asara Chun-Hau Chen Cheng-Yu Tsai Kyle F. Nelson Koichi S Kobayashi Elliot Israel Xiao Zhen Zhou Linda K. Nicholson Kun Ping Lu The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation
description	IL-33 orchestrates type 2 immunity in allergic asthma. Here the authors show, using biochemical, structural and patient data, that upon IL-33 or allergic challenge, the isomerase Pin1 modifies IRAK-M to control the production of pro-inflammatory cytokines in the setting of airway inflammation.
format	article
author	Morris Nechama Jeahoo Kwon Shuo Wei Adrian Tun Kyi Robert S. Welner Iddo Z. Ben-Dov Mohamed S. Arredouani John M. Asara Chun-Hau Chen Cheng-Yu Tsai Kyle F. Nelson Koichi S Kobayashi Elliot Israel Xiao Zhen Zhou Linda K. Nicholson Kun Ping Lu
author_facet	Morris Nechama Jeahoo Kwon Shuo Wei Adrian Tun Kyi Robert S. Welner Iddo Z. Ben-Dov Mohamed S. Arredouani John M. Asara Chun-Hau Chen Cheng-Yu Tsai Kyle F. Nelson Koichi S Kobayashi Elliot Israel Xiao Zhen Zhou Linda K. Nicholson Kun Ping Lu
author_sort	Morris Nechama
title	The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation
title_short	The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation
title_full	The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation
title_fullStr	The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation
title_full_unstemmed	The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation
title_sort	il-33-pin1-irak-m axis is critical for type 2 immunity in il-33-induced allergic airway inflammation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f59a26dd71a44b3c90785a69ce33bbf8
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The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation

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