The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation

IL-33 orchestrates type 2 immunity in allergic asthma. Here the authors show, using biochemical, structural and patient data, that upon IL-33 or allergic challenge, the isomerase Pin1 modifies IRAK-M to control the production of pro-inflammatory cytokines in the setting of airway inflammation.

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Autores principales: Morris Nechama, Jeahoo Kwon, Shuo Wei, Adrian Tun Kyi, Robert S. Welner, Iddo Z. Ben-Dov, Mohamed S. Arredouani, John M. Asara, Chun-Hau Chen, Cheng-Yu Tsai, Kyle F. Nelson, Koichi S Kobayashi, Elliot Israel, Xiao Zhen Zhou, Linda K. Nicholson, Kun Ping Lu
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/f59a26dd71a44b3c90785a69ce33bbf8
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spelling oai:doaj.org-article:f59a26dd71a44b3c90785a69ce33bbf82021-12-02T16:50:10ZThe IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation10.1038/s41467-018-03886-62041-1723https://doaj.org/article/f59a26dd71a44b3c90785a69ce33bbf82018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03886-6https://doaj.org/toc/2041-1723IL-33 orchestrates type 2 immunity in allergic asthma. Here the authors show, using biochemical, structural and patient data, that upon IL-33 or allergic challenge, the isomerase Pin1 modifies IRAK-M to control the production of pro-inflammatory cytokines in the setting of airway inflammation.Morris NechamaJeahoo KwonShuo WeiAdrian Tun KyiRobert S. WelnerIddo Z. Ben-DovMohamed S. ArredouaniJohn M. AsaraChun-Hau ChenCheng-Yu TsaiKyle F. NelsonKoichi S KobayashiElliot IsraelXiao Zhen ZhouLinda K. NicholsonKun Ping LuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Morris Nechama
Jeahoo Kwon
Shuo Wei
Adrian Tun Kyi
Robert S. Welner
Iddo Z. Ben-Dov
Mohamed S. Arredouani
John M. Asara
Chun-Hau Chen
Cheng-Yu Tsai
Kyle F. Nelson
Koichi S Kobayashi
Elliot Israel
Xiao Zhen Zhou
Linda K. Nicholson
Kun Ping Lu
The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation
description IL-33 orchestrates type 2 immunity in allergic asthma. Here the authors show, using biochemical, structural and patient data, that upon IL-33 or allergic challenge, the isomerase Pin1 modifies IRAK-M to control the production of pro-inflammatory cytokines in the setting of airway inflammation.
format article
author Morris Nechama
Jeahoo Kwon
Shuo Wei
Adrian Tun Kyi
Robert S. Welner
Iddo Z. Ben-Dov
Mohamed S. Arredouani
John M. Asara
Chun-Hau Chen
Cheng-Yu Tsai
Kyle F. Nelson
Koichi S Kobayashi
Elliot Israel
Xiao Zhen Zhou
Linda K. Nicholson
Kun Ping Lu
author_facet Morris Nechama
Jeahoo Kwon
Shuo Wei
Adrian Tun Kyi
Robert S. Welner
Iddo Z. Ben-Dov
Mohamed S. Arredouani
John M. Asara
Chun-Hau Chen
Cheng-Yu Tsai
Kyle F. Nelson
Koichi S Kobayashi
Elliot Israel
Xiao Zhen Zhou
Linda K. Nicholson
Kun Ping Lu
author_sort Morris Nechama
title The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation
title_short The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation
title_full The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation
title_fullStr The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation
title_full_unstemmed The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation
title_sort il-33-pin1-irak-m axis is critical for type 2 immunity in il-33-induced allergic airway inflammation
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/f59a26dd71a44b3c90785a69ce33bbf8
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