HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients

Amyotrophic lateral sclerosis (ALS) leads to selective loss of motor neurons. Using motor neurons derived from induced pluripotent stem cells from patients with ALS and FUS mutations, the authors demonstrate that axonal transport deficits that are observed in these cells can be rescued by HDAC6 inhi...

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Autores principales:	Wenting Guo, Maximilian Naujock, Laura Fumagalli, Tijs Vandoorne, Pieter Baatsen, Ruben Boon, Laura Ordovás, Abdulsamie Patel, Marc Welters, Thomas Vanwelden, Natasja Geens, Tine Tricot, Veronick Benoy, Jolien Steyaert, Cynthia Lefebvre-Omar, Werend Boesmans, Matthew Jarpe, Jared Sterneckert, Florian Wegner, Susanne Petri, Delphine Bohl, Pieter Vanden Berghe, Wim Robberecht, Philip Van Damme, Catherine Verfaillie, Ludo Van Den Bosch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f59dc3e6db71437985afab751df3c753
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spelling	oai:doaj.org-article:f59dc3e6db71437985afab751df3c7532021-12-02T14:40:48ZHDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients10.1038/s41467-017-00911-y2041-1723https://doaj.org/article/f59dc3e6db71437985afab751df3c7532017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00911-yhttps://doaj.org/toc/2041-1723Amyotrophic lateral sclerosis (ALS) leads to selective loss of motor neurons. Using motor neurons derived from induced pluripotent stem cells from patients with ALS and FUS mutations, the authors demonstrate that axonal transport deficits that are observed in these cells can be rescued by HDAC6 inhibition.Wenting GuoMaximilian NaujockLaura FumagalliTijs VandoornePieter BaatsenRuben BoonLaura OrdovásAbdulsamie PatelMarc WeltersThomas VanweldenNatasja GeensTine TricotVeronick BenoyJolien SteyaertCynthia Lefebvre-OmarWerend BoesmansMatthew JarpeJared SterneckertFlorian WegnerSusanne PetriDelphine BohlPieter Vanden BergheWim RobberechtPhilip Van DammeCatherine VerfaillieLudo Van Den BoschNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenting Guo Maximilian Naujock Laura Fumagalli Tijs Vandoorne Pieter Baatsen Ruben Boon Laura Ordovás Abdulsamie Patel Marc Welters Thomas Vanwelden Natasja Geens Tine Tricot Veronick Benoy Jolien Steyaert Cynthia Lefebvre-Omar Werend Boesmans Matthew Jarpe Jared Sterneckert Florian Wegner Susanne Petri Delphine Bohl Pieter Vanden Berghe Wim Robberecht Philip Van Damme Catherine Verfaillie Ludo Van Den Bosch HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients
description	Amyotrophic lateral sclerosis (ALS) leads to selective loss of motor neurons. Using motor neurons derived from induced pluripotent stem cells from patients with ALS and FUS mutations, the authors demonstrate that axonal transport deficits that are observed in these cells can be rescued by HDAC6 inhibition.
format	article
author	Wenting Guo Maximilian Naujock Laura Fumagalli Tijs Vandoorne Pieter Baatsen Ruben Boon Laura Ordovás Abdulsamie Patel Marc Welters Thomas Vanwelden Natasja Geens Tine Tricot Veronick Benoy Jolien Steyaert Cynthia Lefebvre-Omar Werend Boesmans Matthew Jarpe Jared Sterneckert Florian Wegner Susanne Petri Delphine Bohl Pieter Vanden Berghe Wim Robberecht Philip Van Damme Catherine Verfaillie Ludo Van Den Bosch
author_facet	Wenting Guo Maximilian Naujock Laura Fumagalli Tijs Vandoorne Pieter Baatsen Ruben Boon Laura Ordovás Abdulsamie Patel Marc Welters Thomas Vanwelden Natasja Geens Tine Tricot Veronick Benoy Jolien Steyaert Cynthia Lefebvre-Omar Werend Boesmans Matthew Jarpe Jared Sterneckert Florian Wegner Susanne Petri Delphine Bohl Pieter Vanden Berghe Wim Robberecht Philip Van Damme Catherine Verfaillie Ludo Van Den Bosch
author_sort	Wenting Guo
title	HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients
title_short	HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients
title_full	HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients
title_fullStr	HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients
title_full_unstemmed	HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients
title_sort	hdac6 inhibition reverses axonal transport defects in motor neurons derived from fus-als patients
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f59dc3e6db71437985afab751df3c753
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HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients

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