Prevalence, serotype and antibiotic susceptibility of Group B Streptococcus isolated from pregnant women in Jakarta, Indonesia.

Group B Streptococcus (GBS) is a bacterial pathogen which is a leading cause of neonatal infection. Currently, there are limited GBS data available from the Indonesian population. In this study, GBS colonization, serotype distribution and antimicrobial susceptibility profile of isolates were investi...

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Autores principales:	Dodi Safari, Septiani Madonna Gultom, Wisnu Tafroji, Athiya Azzahidah, Frida Soesanti, Miftahuddin Majid Khoeri, Ari Prayitno, Fabiana C Pimenta, Maria da Gloria Carvalho, Cuno S P M Uiterwaal, Nina Dwi Putri
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f5a7f2e8e20945519cb9c2a2620eacb2
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spelling	oai:doaj.org-article:f5a7f2e8e20945519cb9c2a2620eacb22021-11-25T06:23:40ZPrevalence, serotype and antibiotic susceptibility of Group B Streptococcus isolated from pregnant women in Jakarta, Indonesia.1932-620310.1371/journal.pone.0252328https://doaj.org/article/f5a7f2e8e20945519cb9c2a2620eacb22021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252328https://doaj.org/toc/1932-6203Group B Streptococcus (GBS) is a bacterial pathogen which is a leading cause of neonatal infection. Currently, there are limited GBS data available from the Indonesian population. In this study, GBS colonization, serotype distribution and antimicrobial susceptibility profile of isolates were investigated among pregnant women in Jakarta, Indonesia. Demographics data, clinical characteristics and vaginal swabs were collected from 177 pregnant women (mean aged: 28.7 years old) at 29-40 weeks of gestation. Bacterial culture identification tests and latex agglutination were performed for GBS. Serotyping was done by conventional multiplex PCR and antibiotic susceptibility testing by broth microdilution. GBS colonization was found in 53 (30%) pregnant women. Serotype II was the most common serotype (30%) followed by serotype III (23%), Ia and IV (13% each), VI (8%), Ib and V (6% each), and one non-typeable strain. All isolates were susceptible to vancomycin, penicillin, ampicillin, cefotaxime, daptomycin and linezolid. The majority of GBS were resistant to tetracycline (89%) followed by clindamycin (21%), erythromycin (19%), and levofloxacin (6%). The serotype III was more resistant to erythromycin, clindamycin, and levofloxacin and these isolates were more likely to be multidrug resistant (6 out of 10) compared to other serotypes. This report provides demographics of GBS colonization and isolate characterization in pregnant women in Indonesia. The results may facilitate preventive strategies to reduce neonatal GBS infection and improve its treatment.Dodi SafariSeptiani Madonna GultomWisnu TafrojiAthiya AzzahidahFrida SoesantiMiftahuddin Majid KhoeriAri PrayitnoFabiana C PimentaMaria da Gloria CarvalhoCuno S P M UiterwaalNina Dwi PutriPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0252328 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dodi Safari Septiani Madonna Gultom Wisnu Tafroji Athiya Azzahidah Frida Soesanti Miftahuddin Majid Khoeri Ari Prayitno Fabiana C Pimenta Maria da Gloria Carvalho Cuno S P M Uiterwaal Nina Dwi Putri Prevalence, serotype and antibiotic susceptibility of Group B Streptococcus isolated from pregnant women in Jakarta, Indonesia.
description	Group B Streptococcus (GBS) is a bacterial pathogen which is a leading cause of neonatal infection. Currently, there are limited GBS data available from the Indonesian population. In this study, GBS colonization, serotype distribution and antimicrobial susceptibility profile of isolates were investigated among pregnant women in Jakarta, Indonesia. Demographics data, clinical characteristics and vaginal swabs were collected from 177 pregnant women (mean aged: 28.7 years old) at 29-40 weeks of gestation. Bacterial culture identification tests and latex agglutination were performed for GBS. Serotyping was done by conventional multiplex PCR and antibiotic susceptibility testing by broth microdilution. GBS colonization was found in 53 (30%) pregnant women. Serotype II was the most common serotype (30%) followed by serotype III (23%), Ia and IV (13% each), VI (8%), Ib and V (6% each), and one non-typeable strain. All isolates were susceptible to vancomycin, penicillin, ampicillin, cefotaxime, daptomycin and linezolid. The majority of GBS were resistant to tetracycline (89%) followed by clindamycin (21%), erythromycin (19%), and levofloxacin (6%). The serotype III was more resistant to erythromycin, clindamycin, and levofloxacin and these isolates were more likely to be multidrug resistant (6 out of 10) compared to other serotypes. This report provides demographics of GBS colonization and isolate characterization in pregnant women in Indonesia. The results may facilitate preventive strategies to reduce neonatal GBS infection and improve its treatment.
format	article
author	Dodi Safari Septiani Madonna Gultom Wisnu Tafroji Athiya Azzahidah Frida Soesanti Miftahuddin Majid Khoeri Ari Prayitno Fabiana C Pimenta Maria da Gloria Carvalho Cuno S P M Uiterwaal Nina Dwi Putri
author_facet	Dodi Safari Septiani Madonna Gultom Wisnu Tafroji Athiya Azzahidah Frida Soesanti Miftahuddin Majid Khoeri Ari Prayitno Fabiana C Pimenta Maria da Gloria Carvalho Cuno S P M Uiterwaal Nina Dwi Putri
author_sort	Dodi Safari
title	Prevalence, serotype and antibiotic susceptibility of Group B Streptococcus isolated from pregnant women in Jakarta, Indonesia.
title_short	Prevalence, serotype and antibiotic susceptibility of Group B Streptococcus isolated from pregnant women in Jakarta, Indonesia.
title_full	Prevalence, serotype and antibiotic susceptibility of Group B Streptococcus isolated from pregnant women in Jakarta, Indonesia.
title_fullStr	Prevalence, serotype and antibiotic susceptibility of Group B Streptococcus isolated from pregnant women in Jakarta, Indonesia.
title_full_unstemmed	Prevalence, serotype and antibiotic susceptibility of Group B Streptococcus isolated from pregnant women in Jakarta, Indonesia.
title_sort	prevalence, serotype and antibiotic susceptibility of group b streptococcus isolated from pregnant women in jakarta, indonesia.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/f5a7f2e8e20945519cb9c2a2620eacb2
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Prevalence, serotype and antibiotic susceptibility of Group B Streptococcus isolated from pregnant women in Jakarta, Indonesia.

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