Autoantibody Profile of Egyptian Juvenile Systemic Lupus Erythematosus Patients and Its Association with Clinical Characteristics and Disease Activity

Mohammed Abd El Monem Teama,1 Marwa Adham El-Mohamdy,2 Fatma Abdellah Abdullah Mahmoud,2 Fatma Mohammed Badr1 1Internal Medicine Department, Division of Rheumatology and Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 2Clinical Pathology Department, Faculty of medicine, Ain Sham...

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Autores principales:	Abd El Monem Teama M, Adham El-Mohamdy M, Abdellah Abdullah Mahmoud F, Mohammed Badr F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	juvenile systemic lupus erythematosus clinical manifestations antibodies to extractable nuclear antigens (anti-ena) disease activity score. Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/f5acae87ef4a4b73adbea34ae80a6f78
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spelling	oai:doaj.org-article:f5acae87ef4a4b73adbea34ae80a6f782021-12-02T18:26:44ZAutoantibody Profile of Egyptian Juvenile Systemic Lupus Erythematosus Patients and Its Association with Clinical Characteristics and Disease Activity1179-156Xhttps://doaj.org/article/f5acae87ef4a4b73adbea34ae80a6f782021-07-01T00:00:00Zhttps://www.dovepress.com/autoantibody-profile-of-egyptian-juvenile-systemic-lupus-erythematosus-peer-reviewed-fulltext-article-OARRRhttps://doaj.org/toc/1179-156XMohammed Abd El Monem Teama,1 Marwa Adham El-Mohamdy,2 Fatma Abdellah Abdullah Mahmoud,2 Fatma Mohammed Badr1 1Internal Medicine Department, Division of Rheumatology and Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 2Clinical Pathology Department, Faculty of medicine, Ain Shams University, Cairo, EgyptCorrespondence: Mohammed Abd El Monem Teama 2 Staff Member Buildings of Ain Shams University, El Al Waili/El-Abaseya, Cairo, 11517, EgyptTel +20 1277580006Email mohteama2009@yahoo.comObjective: This study was conducted to estimate the frequency of anti-nuclear antibodies (ANAs), anti-dsDNA, and anti-extractable nuclear antigen (ENA) antibodies in juvenile systemic lupus erythematosus (JSLE) patients and their association with different clinical manifestations and disease activity.Patients and Methods: A cross-sectional study that includes 100 JSLE patients from Ain Shams University Hospital was conducted. All subjects underwent history taking, clinical examination, assessment of disease activity based on the SLE disease activity index (SLEDAI), laboratory investigations, and tests for autoantibodies, namely ANA, anti-dsDNA, and anti-ENA antibodies, including anti-Ro (SSA), anti-La (SSB), anti-Smith (Sm), and anti-U1-ribonucleoprotein (U1-RNP).Results: The most common clinical features were polyarthralgia (71%), haematological manifestations (65%), malar rash (54%), and nephritis (51%), respectively. All patients had positive ANA (100%), while anti-dsDNA frequency was 83%. The most common anti-ENA antibodies were anti-RNP (41%), anti-Sm (31%), anti-SSA (27%), and anti-SSB (20%), respectively. Anti-RNP had a clinical association with oral ulcer, Raynaud’ phenomena, haematological, neuropsychiatric and thromboembolic manifestations. Meanwhile, anti-Sm had a significant association with serositis, mucocutaneous, constitutional, and neuropsychiatric manifestations. Anti-SSA was associated with mucocutaneous, musculoskeletal, Raynaud’ phenomena, renal, haematological and cardiac manifestations, while anti-SSB was significantly associated with malar rash, serositis, thromboembolic, musculoskeletal, and neuropsychiatric manifestations. Concerning SLEADI score, anti-dsDNA antibody was significantly associated with moderate disease activity score (p=0.032) while anti-SSA significantly associated with high disease activity (p=0.045). Both anti-SSB and anti-Sm were significantly associated with both moderate and high disease activities, meanwhile anti-U1-RNP was associated with moderate disease activity (p=0.014).Conclusion: Anti-dsDNA and anti-ENAs antibodies were frequently found in JSLE patients (83%, 63%), respectively. They were significantly associated with variable clinical manifestations and could be used as predictors for assessment of disease activity.Keywords: juvenile systemic lupus erythematosus, clinical manifestations, anti-ENA, disease activity scoreAbd El Monem Teama MAdham El-Mohamdy MAbdellah Abdullah Mahmoud FMohammed Badr FDove Medical Pressarticlejuvenile systemic lupus erythematosusclinical manifestationsantibodies to extractable nuclear antigens (anti-ena)disease activity score.Diseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 13, Pp 201-212 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	juvenile systemic lupus erythematosus clinical manifestations antibodies to extractable nuclear antigens (anti-ena) disease activity score. Diseases of the musculoskeletal system RC925-935
spellingShingle	juvenile systemic lupus erythematosus clinical manifestations antibodies to extractable nuclear antigens (anti-ena) disease activity score. Diseases of the musculoskeletal system RC925-935 Abd El Monem Teama M Adham El-Mohamdy M Abdellah Abdullah Mahmoud F Mohammed Badr F Autoantibody Profile of Egyptian Juvenile Systemic Lupus Erythematosus Patients and Its Association with Clinical Characteristics and Disease Activity
description	Mohammed Abd El Monem Teama,1 Marwa Adham El-Mohamdy,2 Fatma Abdellah Abdullah Mahmoud,2 Fatma Mohammed Badr1 1Internal Medicine Department, Division of Rheumatology and Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 2Clinical Pathology Department, Faculty of medicine, Ain Shams University, Cairo, EgyptCorrespondence: Mohammed Abd El Monem Teama 2 Staff Member Buildings of Ain Shams University, El Al Waili/El-Abaseya, Cairo, 11517, EgyptTel +20 1277580006Email mohteama2009@yahoo.comObjective: This study was conducted to estimate the frequency of anti-nuclear antibodies (ANAs), anti-dsDNA, and anti-extractable nuclear antigen (ENA) antibodies in juvenile systemic lupus erythematosus (JSLE) patients and their association with different clinical manifestations and disease activity.Patients and Methods: A cross-sectional study that includes 100 JSLE patients from Ain Shams University Hospital was conducted. All subjects underwent history taking, clinical examination, assessment of disease activity based on the SLE disease activity index (SLEDAI), laboratory investigations, and tests for autoantibodies, namely ANA, anti-dsDNA, and anti-ENA antibodies, including anti-Ro (SSA), anti-La (SSB), anti-Smith (Sm), and anti-U1-ribonucleoprotein (U1-RNP).Results: The most common clinical features were polyarthralgia (71%), haematological manifestations (65%), malar rash (54%), and nephritis (51%), respectively. All patients had positive ANA (100%), while anti-dsDNA frequency was 83%. The most common anti-ENA antibodies were anti-RNP (41%), anti-Sm (31%), anti-SSA (27%), and anti-SSB (20%), respectively. Anti-RNP had a clinical association with oral ulcer, Raynaud’ phenomena, haematological, neuropsychiatric and thromboembolic manifestations. Meanwhile, anti-Sm had a significant association with serositis, mucocutaneous, constitutional, and neuropsychiatric manifestations. Anti-SSA was associated with mucocutaneous, musculoskeletal, Raynaud’ phenomena, renal, haematological and cardiac manifestations, while anti-SSB was significantly associated with malar rash, serositis, thromboembolic, musculoskeletal, and neuropsychiatric manifestations. Concerning SLEADI score, anti-dsDNA antibody was significantly associated with moderate disease activity score (p=0.032) while anti-SSA significantly associated with high disease activity (p=0.045). Both anti-SSB and anti-Sm were significantly associated with both moderate and high disease activities, meanwhile anti-U1-RNP was associated with moderate disease activity (p=0.014).Conclusion: Anti-dsDNA and anti-ENAs antibodies were frequently found in JSLE patients (83%, 63%), respectively. They were significantly associated with variable clinical manifestations and could be used as predictors for assessment of disease activity.Keywords: juvenile systemic lupus erythematosus, clinical manifestations, anti-ENA, disease activity score
format	article
author	Abd El Monem Teama M Adham El-Mohamdy M Abdellah Abdullah Mahmoud F Mohammed Badr F
author_facet	Abd El Monem Teama M Adham El-Mohamdy M Abdellah Abdullah Mahmoud F Mohammed Badr F
author_sort	Abd El Monem Teama M
title	Autoantibody Profile of Egyptian Juvenile Systemic Lupus Erythematosus Patients and Its Association with Clinical Characteristics and Disease Activity
title_short	Autoantibody Profile of Egyptian Juvenile Systemic Lupus Erythematosus Patients and Its Association with Clinical Characteristics and Disease Activity
title_full	Autoantibody Profile of Egyptian Juvenile Systemic Lupus Erythematosus Patients and Its Association with Clinical Characteristics and Disease Activity
title_fullStr	Autoantibody Profile of Egyptian Juvenile Systemic Lupus Erythematosus Patients and Its Association with Clinical Characteristics and Disease Activity
title_full_unstemmed	Autoantibody Profile of Egyptian Juvenile Systemic Lupus Erythematosus Patients and Its Association with Clinical Characteristics and Disease Activity
title_sort	autoantibody profile of egyptian juvenile systemic lupus erythematosus patients and its association with clinical characteristics and disease activity
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/f5acae87ef4a4b73adbea34ae80a6f78
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_version_	1718378073741590528

Autoantibody Profile of Egyptian Juvenile Systemic Lupus Erythematosus Patients and Its Association with Clinical Characteristics and Disease Activity

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