The association between serum selenium concentration and prognosis in patients with heart failure in a Chinese population

Abstract Whether Selenium (Se) deficiency relates with adverse prognosis in Chinese patients with heart failure (HF) is still unknown. This study aimed to investigate the association of serum Se level and the outcomes of patients with HF in a Chinese population. Patients with HF and serum Se examina...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhiliang Zhang, Chao Chang, Yuxin Zhang, Zhiyong Chai, Jinbei Li, Chunguang Qiu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f5ae9eb1870d47de8ea50c84385fe2a4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f5ae9eb1870d47de8ea50c84385fe2a4
record_format	dspace
spelling	oai:doaj.org-article:f5ae9eb1870d47de8ea50c84385fe2a42021-12-02T16:08:06ZThe association between serum selenium concentration and prognosis in patients with heart failure in a Chinese population10.1038/s41598-021-93873-72045-2322https://doaj.org/article/f5ae9eb1870d47de8ea50c84385fe2a42021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93873-7https://doaj.org/toc/2045-2322Abstract Whether Selenium (Se) deficiency relates with adverse prognosis in Chinese patients with heart failure (HF) is still unknown. This study aimed to investigate the association of serum Se level and the outcomes of patients with HF in a Chinese population. Patients with HF and serum Se examination were retrospectively included. Baseline information were collected at patient’s first admission. The primary and secondary outcomes were all-cause mortality and rehospitalization for HF during follow-up, respectively. The study participants were divided into quartiles according to their serum Se concentrations. The Cox proportional hazard models were adopted to estimate the association of serum Se levels with observed outcomes. A total of 411 patients with HF with a mean age of 62.5 years were included. The mean serum level of Se was 68.3 ± 27.7 µg/L. There was nonsignificant difference of baseline characterizes between the four quartile groups. In comparison with patients in the highest quartile, those with the lowest quartile (17.40–44.35 µg/L) were associated with increased risk of all-cause mortality [adjusted hazard ratios (95% CI) 2.32 (1.43–3.77); P trend = 0.001]. Our study suggested that a lower serum Se level was significantly associated with increased risk of all-cause mortality in patients with HF.Zhiliang ZhangChao ChangYuxin ZhangZhiyong ChaiJinbei LiChunguang QiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhiliang Zhang Chao Chang Yuxin Zhang Zhiyong Chai Jinbei Li Chunguang Qiu The association between serum selenium concentration and prognosis in patients with heart failure in a Chinese population
description	Abstract Whether Selenium (Se) deficiency relates with adverse prognosis in Chinese patients with heart failure (HF) is still unknown. This study aimed to investigate the association of serum Se level and the outcomes of patients with HF in a Chinese population. Patients with HF and serum Se examination were retrospectively included. Baseline information were collected at patient’s first admission. The primary and secondary outcomes were all-cause mortality and rehospitalization for HF during follow-up, respectively. The study participants were divided into quartiles according to their serum Se concentrations. The Cox proportional hazard models were adopted to estimate the association of serum Se levels with observed outcomes. A total of 411 patients with HF with a mean age of 62.5 years were included. The mean serum level of Se was 68.3 ± 27.7 µg/L. There was nonsignificant difference of baseline characterizes between the four quartile groups. In comparison with patients in the highest quartile, those with the lowest quartile (17.40–44.35 µg/L) were associated with increased risk of all-cause mortality [adjusted hazard ratios (95% CI) 2.32 (1.43–3.77); P trend = 0.001]. Our study suggested that a lower serum Se level was significantly associated with increased risk of all-cause mortality in patients with HF.
format	article
author	Zhiliang Zhang Chao Chang Yuxin Zhang Zhiyong Chai Jinbei Li Chunguang Qiu
author_facet	Zhiliang Zhang Chao Chang Yuxin Zhang Zhiyong Chai Jinbei Li Chunguang Qiu
author_sort	Zhiliang Zhang
title	The association between serum selenium concentration and prognosis in patients with heart failure in a Chinese population
title_short	The association between serum selenium concentration and prognosis in patients with heart failure in a Chinese population
title_full	The association between serum selenium concentration and prognosis in patients with heart failure in a Chinese population
title_fullStr	The association between serum selenium concentration and prognosis in patients with heart failure in a Chinese population
title_full_unstemmed	The association between serum selenium concentration and prognosis in patients with heart failure in a Chinese population
title_sort	association between serum selenium concentration and prognosis in patients with heart failure in a chinese population
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f5ae9eb1870d47de8ea50c84385fe2a4
work_keys_str_mv	AT zhiliangzhang theassociationbetweenserumseleniumconcentrationandprognosisinpatientswithheartfailureinachinesepopulation AT chaochang theassociationbetweenserumseleniumconcentrationandprognosisinpatientswithheartfailureinachinesepopulation AT yuxinzhang theassociationbetweenserumseleniumconcentrationandprognosisinpatientswithheartfailureinachinesepopulation AT zhiyongchai theassociationbetweenserumseleniumconcentrationandprognosisinpatientswithheartfailureinachinesepopulation AT jinbeili theassociationbetweenserumseleniumconcentrationandprognosisinpatientswithheartfailureinachinesepopulation AT chunguangqiu theassociationbetweenserumseleniumconcentrationandprognosisinpatientswithheartfailureinachinesepopulation AT zhiliangzhang associationbetweenserumseleniumconcentrationandprognosisinpatientswithheartfailureinachinesepopulation AT chaochang associationbetweenserumseleniumconcentrationandprognosisinpatientswithheartfailureinachinesepopulation AT yuxinzhang associationbetweenserumseleniumconcentrationandprognosisinpatientswithheartfailureinachinesepopulation AT zhiyongchai associationbetweenserumseleniumconcentrationandprognosisinpatientswithheartfailureinachinesepopulation AT jinbeili associationbetweenserumseleniumconcentrationandprognosisinpatientswithheartfailureinachinesepopulation AT chunguangqiu associationbetweenserumseleniumconcentrationandprognosisinpatientswithheartfailureinachinesepopulation
_version_	1718384631966859264

The association between serum selenium concentration and prognosis in patients with heart failure in a Chinese population

Ejemplares similares