Safety assessment of the ethanolic extract from Piper vicosanum yunck leaves in male rats

Background: Piper vicosanum (Piperaceae) is a species used in folk medicine mainly due to its anti-inflammatory and analgesic properties. However, the data available about its safety are still insufficient. Purpose: This study evaluated the toxicological profile and reproductive impacts in male rats...

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Autores principales:	Bárbara Campos Jorge, Armando Jorge Júnior, Julia Stein, Ana Carolina Casali Reis, Suyane da Silva Moreira, Beatriz de Matos Manoel, Jonas da Silva Mota, Cândida Aparecida Leite Kassuya, Arielle Cristina Arena
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Piper Safety evaluation Biochemical parameters Reproductive toxicity Sperm morphology Male rats Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/f5b219d9f1b2480da52ca865261cb0aa
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spelling	oai:doaj.org-article:f5b219d9f1b2480da52ca865261cb0aa2021-11-26T04:42:42ZSafety assessment of the ethanolic extract from Piper vicosanum yunck leaves in male rats2667-031310.1016/j.phyplu.2021.100165https://doaj.org/article/f5b219d9f1b2480da52ca865261cb0aa2022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667031321001470https://doaj.org/toc/2667-0313Background: Piper vicosanum (Piperaceae) is a species used in folk medicine mainly due to its anti-inflammatory and analgesic properties. However, the data available about its safety are still insufficient. Purpose: This study evaluated the toxicological profile and reproductive impacts in male rats treated with the ethanolic extract from Piper vicosanum leaves (EEPV) during a 28-day treatment. Methods: Male Wistar rats received ethanol extract of EEPV (0, 100, 200, or 300 mg/kg) by gavage for 28 consecutive days. Results: Males treated with EEPV did not exhibit clinical signs of toxicity during the treatment. Although hematological parameters were unaltered, a decrease in AST, total proteins, alkaline phosphatase and creatinine levels was observed in the treated animals. However, no evidence of histological changes was found in the liver and kidney. EEPV also induced an increase of abnormal sperm in males. Conclusion: The prolonged use of ethanolic extract of Piper vicosanum leaves affected biochemical and sperm parameters, showing that care should be taken when it is used for prolonged periods. Further studies, including a 90-day toxicity assay, should be performed.Bárbara Campos JorgeArmando Jorge JúniorJulia SteinAna Carolina Casali ReisSuyane da Silva MoreiraBeatriz de Matos ManoelJonas da Silva MotaCândida Aparecida Leite KassuyaArielle Cristina ArenaElsevierarticlePiperSafety evaluationBiochemical parametersReproductive toxicitySperm morphologyMale ratsOther systems of medicineRZ201-999ENPhytomedicine Plus, Vol 2, Iss 1, Pp 100165- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Piper Safety evaluation Biochemical parameters Reproductive toxicity Sperm morphology Male rats Other systems of medicine RZ201-999
spellingShingle	Piper Safety evaluation Biochemical parameters Reproductive toxicity Sperm morphology Male rats Other systems of medicine RZ201-999 Bárbara Campos Jorge Armando Jorge Júnior Julia Stein Ana Carolina Casali Reis Suyane da Silva Moreira Beatriz de Matos Manoel Jonas da Silva Mota Cândida Aparecida Leite Kassuya Arielle Cristina Arena Safety assessment of the ethanolic extract from Piper vicosanum yunck leaves in male rats
description	Background: Piper vicosanum (Piperaceae) is a species used in folk medicine mainly due to its anti-inflammatory and analgesic properties. However, the data available about its safety are still insufficient. Purpose: This study evaluated the toxicological profile and reproductive impacts in male rats treated with the ethanolic extract from Piper vicosanum leaves (EEPV) during a 28-day treatment. Methods: Male Wistar rats received ethanol extract of EEPV (0, 100, 200, or 300 mg/kg) by gavage for 28 consecutive days. Results: Males treated with EEPV did not exhibit clinical signs of toxicity during the treatment. Although hematological parameters were unaltered, a decrease in AST, total proteins, alkaline phosphatase and creatinine levels was observed in the treated animals. However, no evidence of histological changes was found in the liver and kidney. EEPV also induced an increase of abnormal sperm in males. Conclusion: The prolonged use of ethanolic extract of Piper vicosanum leaves affected biochemical and sperm parameters, showing that care should be taken when it is used for prolonged periods. Further studies, including a 90-day toxicity assay, should be performed.
format	article
author	Bárbara Campos Jorge Armando Jorge Júnior Julia Stein Ana Carolina Casali Reis Suyane da Silva Moreira Beatriz de Matos Manoel Jonas da Silva Mota Cândida Aparecida Leite Kassuya Arielle Cristina Arena
author_facet	Bárbara Campos Jorge Armando Jorge Júnior Julia Stein Ana Carolina Casali Reis Suyane da Silva Moreira Beatriz de Matos Manoel Jonas da Silva Mota Cândida Aparecida Leite Kassuya Arielle Cristina Arena
author_sort	Bárbara Campos Jorge
title	Safety assessment of the ethanolic extract from Piper vicosanum yunck leaves in male rats
title_short	Safety assessment of the ethanolic extract from Piper vicosanum yunck leaves in male rats
title_full	Safety assessment of the ethanolic extract from Piper vicosanum yunck leaves in male rats
title_fullStr	Safety assessment of the ethanolic extract from Piper vicosanum yunck leaves in male rats
title_full_unstemmed	Safety assessment of the ethanolic extract from Piper vicosanum yunck leaves in male rats
title_sort	safety assessment of the ethanolic extract from piper vicosanum yunck leaves in male rats
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/f5b219d9f1b2480da52ca865261cb0aa
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Safety assessment of the ethanolic extract from Piper vicosanum yunck leaves in male rats

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