In vivo genetic manipulation of inner ear connexin expression by bovine adeno-associated viral vectors

In vivo genetic manipulation of inner ear connexin expression by bovine adeno-associated viral vectors

Abstract We have previously shown that in vitro transduction with bovine adeno–associated viral (BAAV) vectors restores connexin expression and rescues gap junction coupling in cochlear organotypic cultures from connexin–deficient mice that are models DFNB1 nonsyndromic hearing loss and deafness. Th...

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Autores principales: Giulia Crispino, Fabian Galindo Ramirez, Matteo Campioni, Veronica Zorzi, Mark Praetorius, Giovanni Di Pasquale, John A. Chiorini, Fabio Mammano
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/f5b21be5ccfe4f96b4c632312c5f3207
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