Preventive effect of celecoxib use against cancer progression and occurrence of oral squamous cell carcinoma

Abstract Overexpression of cyclooxygenase-2 in oral cancer increases lymph node metastasis and is associated with a poor prognosis. The potential of celecoxib (CXB) use is reported in cancer treatment by inhibiting proliferation through apoptosis, but the effects on the epithelial-mesenchymal transi...

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Autores principales:	Shang-Lun Chiang, Bharath Kumar Velmurugan, Chia-Min Chung, Shu-Hui Lin, Zhi-Hong Wang, Chun-Hung Hua, Ming-Hsui Tsai, Tzer-Min Kuo, Kun-Tu Yeh, Pei-Ying Chang, Yi-Hsin Yang, Ying-Chin Ko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f5b4d22d1c4744308fb7eba53f6d715c
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spelling	oai:doaj.org-article:f5b4d22d1c4744308fb7eba53f6d715c2021-12-02T16:08:00ZPreventive effect of celecoxib use against cancer progression and occurrence of oral squamous cell carcinoma10.1038/s41598-017-06673-32045-2322https://doaj.org/article/f5b4d22d1c4744308fb7eba53f6d715c2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06673-3https://doaj.org/toc/2045-2322Abstract Overexpression of cyclooxygenase-2 in oral cancer increases lymph node metastasis and is associated with a poor prognosis. The potential of celecoxib (CXB) use is reported in cancer treatment by inhibiting proliferation through apoptosis, but the effects on the epithelial-mesenchymal transition (EMT) and cancer cell mobility remain unclear. We performed a preclinical study and population-based study to evaluate CXB use in the prevention of oral cancer progression and occurrence. The in-vitro findings showed that CXB is involved in the inhibition of EMT and cell mobility through blocking transcription factors (Slug, Snail and ZEB1), cytoplasmic mediators (focal adhesion kinase (FAK), vimentin and β-catenin), cell adhesion molecules (cadherins and integrins), and surface receptors (AMFR and EGFR). The murine xenograft model showed a 65% inhibition in tumour growth after a 5-week treatment of CXB compared to placebo. Xenograft tumours in placebo-treated mice displayed a well-to-moderate/moderate differentiated SCC grade, while those from CXB-treated mice were well differentiated. The expression levels of membrane EGFR, and nuclear FAK, Slug and ZEB1 were decreased in the xenograft tumours of CXB-treated mice. A retrospective cohort study showed that increasing the daily dose and medication time of CXB was associated with oral cancer prevention. The findings provide an alternative prevention strategy for oral cancer development with CXB use.Shang-Lun ChiangBharath Kumar VelmuruganChia-Min ChungShu-Hui LinZhi-Hong WangChun-Hung HuaMing-Hsui TsaiTzer-Min KuoKun-Tu YehPei-Ying ChangYi-Hsin YangYing-Chin KoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shang-Lun Chiang Bharath Kumar Velmurugan Chia-Min Chung Shu-Hui Lin Zhi-Hong Wang Chun-Hung Hua Ming-Hsui Tsai Tzer-Min Kuo Kun-Tu Yeh Pei-Ying Chang Yi-Hsin Yang Ying-Chin Ko Preventive effect of celecoxib use against cancer progression and occurrence of oral squamous cell carcinoma
description	Abstract Overexpression of cyclooxygenase-2 in oral cancer increases lymph node metastasis and is associated with a poor prognosis. The potential of celecoxib (CXB) use is reported in cancer treatment by inhibiting proliferation through apoptosis, but the effects on the epithelial-mesenchymal transition (EMT) and cancer cell mobility remain unclear. We performed a preclinical study and population-based study to evaluate CXB use in the prevention of oral cancer progression and occurrence. The in-vitro findings showed that CXB is involved in the inhibition of EMT and cell mobility through blocking transcription factors (Slug, Snail and ZEB1), cytoplasmic mediators (focal adhesion kinase (FAK), vimentin and β-catenin), cell adhesion molecules (cadherins and integrins), and surface receptors (AMFR and EGFR). The murine xenograft model showed a 65% inhibition in tumour growth after a 5-week treatment of CXB compared to placebo. Xenograft tumours in placebo-treated mice displayed a well-to-moderate/moderate differentiated SCC grade, while those from CXB-treated mice were well differentiated. The expression levels of membrane EGFR, and nuclear FAK, Slug and ZEB1 were decreased in the xenograft tumours of CXB-treated mice. A retrospective cohort study showed that increasing the daily dose and medication time of CXB was associated with oral cancer prevention. The findings provide an alternative prevention strategy for oral cancer development with CXB use.
format	article
author	Shang-Lun Chiang Bharath Kumar Velmurugan Chia-Min Chung Shu-Hui Lin Zhi-Hong Wang Chun-Hung Hua Ming-Hsui Tsai Tzer-Min Kuo Kun-Tu Yeh Pei-Ying Chang Yi-Hsin Yang Ying-Chin Ko
author_facet	Shang-Lun Chiang Bharath Kumar Velmurugan Chia-Min Chung Shu-Hui Lin Zhi-Hong Wang Chun-Hung Hua Ming-Hsui Tsai Tzer-Min Kuo Kun-Tu Yeh Pei-Ying Chang Yi-Hsin Yang Ying-Chin Ko
author_sort	Shang-Lun Chiang
title	Preventive effect of celecoxib use against cancer progression and occurrence of oral squamous cell carcinoma
title_short	Preventive effect of celecoxib use against cancer progression and occurrence of oral squamous cell carcinoma
title_full	Preventive effect of celecoxib use against cancer progression and occurrence of oral squamous cell carcinoma
title_fullStr	Preventive effect of celecoxib use against cancer progression and occurrence of oral squamous cell carcinoma
title_full_unstemmed	Preventive effect of celecoxib use against cancer progression and occurrence of oral squamous cell carcinoma
title_sort	preventive effect of celecoxib use against cancer progression and occurrence of oral squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f5b4d22d1c4744308fb7eba53f6d715c
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Preventive effect of celecoxib use against cancer progression and occurrence of oral squamous cell carcinoma

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