Higher PGD2 production by synovial mast cells from rheumatoid arthritis patients compared with osteoarthritis patients via miR-199a-3p/prostaglandin synthetase 2 axis

Higher PGD2 production by synovial mast cells from rheumatoid arthritis patients compared with osteoarthritis patients via miR-199a-3p/prostaglandin synthetase 2 axis

Abstract We previously reported that synovial mast cells (MCs) from patients with rheumatoid arthritis (RA) produced TNF-α in response to immune complexes via FcγRI and FcγRIIA. However, the specific functions of synovial MCs in RA remain unclear. This study aimed to elucidate those functions. Synov...

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Bibliographic Details
Main Authors: Shintaro Mishima, Jun-ichi Kashiwakura, Shota Toyoshima, Tomomi Sasaki-Sakamoto, Yutaka Sano, Kazuyoshi Nakanishi, Kenji Matsumoto, Yoshimichi Okayama
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/f5b5fbc6f1e848db976dde89bfbb4662
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