Clinical and trichoscopic features in 18 cases of Folliculotropic Mycosis Fungoides with scalp involvement

Abstract Folliculotropic Mycosis Fungoides (FMF) is a rare variant of Mycosis Fungoides involving the scalp leading to alopecia. The clinical and trichoscopic features in 18 patients were analyzed and compared with the reports in the literature. Gender, age, disease stage, site of onset were taken i...

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Autores principales:	Giuseppe Gallo, Alessandro Pileri, Michela Starace, Aurora Alessandrini, Alba Guglielmo, Simone Ribero, Pietro Quaglino, Bianca Maria Piraccini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f5b7a19b73f348768636fda900194fc5
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spelling	oai:doaj.org-article:f5b7a19b73f348768636fda900194fc52021-12-02T15:52:55ZClinical and trichoscopic features in 18 cases of Folliculotropic Mycosis Fungoides with scalp involvement10.1038/s41598-021-90168-92045-2322https://doaj.org/article/f5b7a19b73f348768636fda900194fc52021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90168-9https://doaj.org/toc/2045-2322Abstract Folliculotropic Mycosis Fungoides (FMF) is a rare variant of Mycosis Fungoides involving the scalp leading to alopecia. The clinical and trichoscopic features in 18 patients were analyzed and compared with the reports in the literature. Gender, age, disease stage, site of onset were taken into consideration. Clinical and trichoscopic analyses were performed on each patient. From a clinical point of view, Folliculotropic Mycosis Fungoides lesions involving the scalp presented as generalized alopecia (27.8%) or patchy-plaque alopecia (72.2%). Trichoscopic analysis revealed six most frequent features: single hair (83.3%), dotted dilated vessels (77.8%), broken-dystrophic hairs (66.7%), vellus hairs (61.1%), spermatozoa-like pattern vessels (55.6%), and yellow dots (55.6%). Additional identified trichoscopic patterns were dilation of follicular openings, scales-crusts, purpuric dots, short hair with split-end, pigtail hairs, perifollicular hyperkeratosis, milky-white globules, black dots, white dots/lines and absence of follicular dots. These trichoscopic features were further correlated to clinical presentations and stage of the disease. The rarity of the disease is a limitation. The relatively high number of patients allowed to identify several clinical and trichoscopic patterns that could be featured as specific or highly suspicious for FMF in order to consider trichoscopy as a complementary diagnostic approach and improve the differential diagnoses between FMF and other scalp disorders.Giuseppe GalloAlessandro PileriMichela StaraceAurora AlessandriniAlba GuglielmoSimone RiberoPietro QuaglinoBianca Maria PiracciniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Giuseppe Gallo Alessandro Pileri Michela Starace Aurora Alessandrini Alba Guglielmo Simone Ribero Pietro Quaglino Bianca Maria Piraccini Clinical and trichoscopic features in 18 cases of Folliculotropic Mycosis Fungoides with scalp involvement
description	Abstract Folliculotropic Mycosis Fungoides (FMF) is a rare variant of Mycosis Fungoides involving the scalp leading to alopecia. The clinical and trichoscopic features in 18 patients were analyzed and compared with the reports in the literature. Gender, age, disease stage, site of onset were taken into consideration. Clinical and trichoscopic analyses were performed on each patient. From a clinical point of view, Folliculotropic Mycosis Fungoides lesions involving the scalp presented as generalized alopecia (27.8%) or patchy-plaque alopecia (72.2%). Trichoscopic analysis revealed six most frequent features: single hair (83.3%), dotted dilated vessels (77.8%), broken-dystrophic hairs (66.7%), vellus hairs (61.1%), spermatozoa-like pattern vessels (55.6%), and yellow dots (55.6%). Additional identified trichoscopic patterns were dilation of follicular openings, scales-crusts, purpuric dots, short hair with split-end, pigtail hairs, perifollicular hyperkeratosis, milky-white globules, black dots, white dots/lines and absence of follicular dots. These trichoscopic features were further correlated to clinical presentations and stage of the disease. The rarity of the disease is a limitation. The relatively high number of patients allowed to identify several clinical and trichoscopic patterns that could be featured as specific or highly suspicious for FMF in order to consider trichoscopy as a complementary diagnostic approach and improve the differential diagnoses between FMF and other scalp disorders.
format	article
author	Giuseppe Gallo Alessandro Pileri Michela Starace Aurora Alessandrini Alba Guglielmo Simone Ribero Pietro Quaglino Bianca Maria Piraccini
author_facet	Giuseppe Gallo Alessandro Pileri Michela Starace Aurora Alessandrini Alba Guglielmo Simone Ribero Pietro Quaglino Bianca Maria Piraccini
author_sort	Giuseppe Gallo
title	Clinical and trichoscopic features in 18 cases of Folliculotropic Mycosis Fungoides with scalp involvement
title_short	Clinical and trichoscopic features in 18 cases of Folliculotropic Mycosis Fungoides with scalp involvement
title_full	Clinical and trichoscopic features in 18 cases of Folliculotropic Mycosis Fungoides with scalp involvement
title_fullStr	Clinical and trichoscopic features in 18 cases of Folliculotropic Mycosis Fungoides with scalp involvement
title_full_unstemmed	Clinical and trichoscopic features in 18 cases of Folliculotropic Mycosis Fungoides with scalp involvement
title_sort	clinical and trichoscopic features in 18 cases of folliculotropic mycosis fungoides with scalp involvement
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f5b7a19b73f348768636fda900194fc5
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Clinical and trichoscopic features in 18 cases of Folliculotropic Mycosis Fungoides with scalp involvement

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